Reviewed, UniProtKB/Swiss-Prot Q83AZ6 (HEM6_COXBU)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen 3 oxidase, aerobic
    EC=1.3.3.3
Alternative name(s):
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase

Gene names

Name:	hemF
Ordered Locus Names:	CBU_1729

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Coproporphyrinogen 3 oxidase, aerobic		PRO_0000109893

Sequences

	Sequence		Length	Mass (Da)
	Q83AZ6-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0E2DCFE0850B51B3	FASTA	310	36,452
	10 20 30 40 50 60 MRKDRQNKIT EVGIYLKDLQ NRLCRAFEKE EGESRFQETL WEKPNGGGGR TRLLTEGHVI 70 80 90 100 110 120 EQGGVNFSCV YGNQLPPAAT QKHPEISGFA FQAEGLSLVI HPRNPYVPTV HANFRFFIAG 130 140 150 160 170 180 KDEADPRWWF GGGYDLTPYY GFEEDCRHWH RVAKKACDRF GEAIYPRFKA ACDDYFYLKH 190 200 210 220 230 240 RNEPRGIGGL FFDDLNEWEF KRCFEFIKIL GDSFLEAYLP IMQNRKNHPY GERQREFQLY 250 260 270 280 290 300 RRGRYVEFNL LYDRGTRFGL EFGGRTESIL MSLPPRVVWR PNWEPEPGSE EARLYEDYLV 310 RRNWVSVSGA

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO91224.1.
RefSeq	NP_820710.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1209640.
GenomeReviews	Gene locus CBU_1729 in contig AE016828_GR.
KEGG	cbu:CBU_1729.
NMPDR	fig|227377.1.peg.1654.
TIGR	CBU_1729.
Phylogenomic databases
HOGENOM	Q83AZ6.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_1729-MON.
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_COXBU

Accession

Primary (citable) accession number: Q83AZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 2003
Last modified:	November 4, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)