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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31SubstrateUniRule annotation1
Binding sitei108SubstrateUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Binding sitei192ATPUniRule annotation1
Binding sitei314ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi340 – 343ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:CBU_1782
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459381 – 391Phosphoglycerate kinaseAdd BLAST391

Proteomic databases

PRIDEiQ83AU6.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1782.

Structurei

Secondary structure

1391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 3Combined sources3
Beta strandi10 – 15Combined sources6
Beta strandi25 – 27Combined sources3
Helixi30 – 44Combined sources15
Beta strandi48 – 53Combined sources6
Helixi65 – 67Combined sources3
Helixi70 – 78Combined sources9
Beta strandi86 – 89Combined sources4
Helixi90 – 92Combined sources3
Beta strandi101 – 104Combined sources4
Helixi107 – 109Combined sources3
Turni111 – 116Combined sources6
Helixi118 – 126Combined sources9
Beta strandi129 – 133Combined sources5
Helixi136 – 138Combined sources3
Turni144 – 147Combined sources4
Helixi148 – 152Combined sources5
Beta strandi154 – 158Combined sources5
Helixi160 – 174Combined sources15
Beta strandi178 – 187Combined sources10
Helixi189 – 191Combined sources3
Helixi193 – 200Combined sources8
Beta strandi204 – 210Combined sources7
Helixi211 – 219Combined sources9
Helixi231 – 233Combined sources3
Helixi234 – 247Combined sources14
Beta strandi255 – 262Combined sources8
Beta strandi270 – 273Combined sources4
Helixi274 – 276Combined sources3
Beta strandi282 – 286Combined sources5
Helixi288 – 300Combined sources13
Beta strandi302 – 308Combined sources7
Helixi320 – 331Combined sources12
Beta strandi334 – 338Combined sources5
Helixi341 – 349Combined sources9
Helixi353 – 355Combined sources3
Beta strandi356 – 359Combined sources4
Helixi364 – 371Combined sources8
Helixi376 – 385Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NG4X-ray2.78A/B/C1-388[»]
ProteinModelPortaliQ83AU6.
SMRiQ83AU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 18Substrate bindingUniRule annotation3
Regioni54 – 57Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
HOGENOMiHOG000227107.
KOiK00927.
OMAiAGHPVGK.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83AU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLNLHNKR VMIREDLNVP MKNGKITNDE RIVRALPTIQ KAIEQKARVM
60 70 80 90 100
ILSHLGRPEE GKFEKEFSLA PVARLLSKKL NQKVPLINDW LKGVAVEPGQ
110 120 130 140 150
AILCENVRFN KGENENNTEL AKRMAELCDI FVMDAFATAH RAQASTAGVA
160 170 180 190 200
AYAKLACAGP LLISEVEALS RALENPQKPL VAVVGGSKVS TKIHLLENLL
210 220 230 240 250
DKVDQLIVGG GIANTFLKAQ GYSIGKSLCE NEWLDAAQQF WEKAAEKNVS
260 270 280 290 300
LPLPVDVIVA DELSEDAKAT VKNIDAVTSN ESIFDVGPNT SATYAKLMAQ
310 320 330 340 350
AGTIVWNGPI GVFEIEAFSQ GTRALAQAVA KSTAYSIVGG GDTLAALDKF
360 370 380 390
NLTDQMSYVS TAGGAFLEFL EGKILPAIKI LTQRAKEYEQ K
Length:391
Mass (Da):42,363
Last modified:June 1, 2003 - v1
Checksum:iA569E166D68D5ADE
GO

Sequence cautioni

The sequence AAO91276 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91276.2. Different initiation.
RefSeqiNP_820762.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91276; AAO91276; CBU_1782.
GeneIDi1209693.
KEGGicbu:CBU_1782.
PATRICi17932301. VBICoxBur82552_1769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91276.2. Different initiation.
RefSeqiNP_820762.2. NC_002971.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NG4X-ray2.78A/B/C1-388[»]
ProteinModelPortaliQ83AU6.
SMRiQ83AU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1782.

Proteomic databases

PRIDEiQ83AU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO91276; AAO91276; CBU_1782.
GeneIDi1209693.
KEGGicbu:CBU_1782.
PATRICi17932301. VBICoxBur82552_1769.

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
HOGENOMiHOG000227107.
KOiK00927.
OMAiAGHPVGK.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_COXBU
AccessioniPrimary (citable) accession number: Q83AU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.