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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311SubstrateUniRule annotation
Binding sitei108 – 1081SubstrateUniRule annotation
Binding sitei141 – 1411SubstrateUniRule annotation
Binding sitei192 – 1921ATPUniRule annotation
Binding sitei314 – 3141ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi340 – 3434ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1754-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:CBU_1782
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Phosphoglycerate kinasePRO_0000145938Add
BLAST

Proteomic databases

PRIDEiQ83AU6.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1782.

Structurei

Secondary structure

391
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 33Combined sources
Beta strandi10 – 156Combined sources
Beta strandi25 – 273Combined sources
Helixi30 – 4415Combined sources
Beta strandi48 – 536Combined sources
Helixi65 – 673Combined sources
Helixi70 – 789Combined sources
Beta strandi86 – 894Combined sources
Helixi90 – 923Combined sources
Beta strandi101 – 1044Combined sources
Helixi107 – 1093Combined sources
Turni111 – 1166Combined sources
Helixi118 – 1269Combined sources
Beta strandi129 – 1335Combined sources
Helixi136 – 1383Combined sources
Turni144 – 1474Combined sources
Helixi148 – 1525Combined sources
Beta strandi154 – 1585Combined sources
Helixi160 – 17415Combined sources
Beta strandi178 – 18710Combined sources
Helixi189 – 1913Combined sources
Helixi193 – 2008Combined sources
Beta strandi204 – 2107Combined sources
Helixi211 – 2199Combined sources
Helixi231 – 2333Combined sources
Helixi234 – 24714Combined sources
Beta strandi255 – 2628Combined sources
Beta strandi270 – 2734Combined sources
Helixi274 – 2763Combined sources
Beta strandi282 – 2865Combined sources
Helixi288 – 30013Combined sources
Beta strandi302 – 3087Combined sources
Helixi320 – 33112Combined sources
Beta strandi334 – 3385Combined sources
Helixi341 – 3499Combined sources
Helixi353 – 3553Combined sources
Beta strandi356 – 3594Combined sources
Helixi364 – 3718Combined sources
Helixi376 – 38510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NG4X-ray2.78A/B/C1-388[»]
ProteinModelPortaliQ83AU6.
SMRiQ83AU6. Positions 1-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni16 – 183Substrate bindingUniRule annotation
Regioni54 – 574Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
HOGENOMiHOG000227107.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83AU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLNLHNKR VMIREDLNVP MKNGKITNDE RIVRALPTIQ KAIEQKARVM
60 70 80 90 100
ILSHLGRPEE GKFEKEFSLA PVARLLSKKL NQKVPLINDW LKGVAVEPGQ
110 120 130 140 150
AILCENVRFN KGENENNTEL AKRMAELCDI FVMDAFATAH RAQASTAGVA
160 170 180 190 200
AYAKLACAGP LLISEVEALS RALENPQKPL VAVVGGSKVS TKIHLLENLL
210 220 230 240 250
DKVDQLIVGG GIANTFLKAQ GYSIGKSLCE NEWLDAAQQF WEKAAEKNVS
260 270 280 290 300
LPLPVDVIVA DELSEDAKAT VKNIDAVTSN ESIFDVGPNT SATYAKLMAQ
310 320 330 340 350
AGTIVWNGPI GVFEIEAFSQ GTRALAQAVA KSTAYSIVGG GDTLAALDKF
360 370 380 390
NLTDQMSYVS TAGGAFLEFL EGKILPAIKI LTQRAKEYEQ K
Length:391
Mass (Da):42,363
Last modified:June 1, 2003 - v1
Checksum:iA569E166D68D5ADE
GO

Sequence cautioni

The sequence AAO91276.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91276.2. Different initiation.
RefSeqiNP_820762.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91276; AAO91276; CBU_1782.
GeneIDi1209693.
KEGGicbu:CBU_1782.
PATRICi17932301. VBICoxBur82552_1769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91276.2. Different initiation.
RefSeqiNP_820762.2. NC_002971.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NG4X-ray2.78A/B/C1-388[»]
ProteinModelPortaliQ83AU6.
SMRiQ83AU6. Positions 1-387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1782.

Proteomic databases

PRIDEiQ83AU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO91276; AAO91276; CBU_1782.
GeneIDi1209693.
KEGGicbu:CBU_1782.
PATRICi17932301. VBICoxBur82552_1769.

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
HOGENOMiHOG000227107.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciCBUR227377:GJ7S-1754-MONOMER.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiPGK_COXBU
AccessioniPrimary (citable) accession number: Q83AU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.