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Q83AR8

- PDXB_COXBU

UniProt

Q83AR8 - PDXB_COXBU

Protein

Erythronate-4-phosphate dehydrogenase

Gene

pdxB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.UniRule annotation

    Catalytic activityi

    4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461SubstrateUniRule annotation
    Binding sitei67 – 671SubstrateUniRule annotation
    Binding sitei147 – 1471NADUniRule annotation
    Binding sitei175 – 1751NAD; via carbonyl oxygenUniRule annotation
    Active sitei208 – 2081UniRule annotation
    Binding sitei228 – 2281NADUniRule annotation
    Active sitei233 – 2331UniRule annotation
    Active sitei250 – 2501Proton donorUniRule annotation
    Binding sitei253 – 2531NAD; via amide nitrogenUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-phosphoerythronate dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1785-MONOMER.
    UniPathwayiUPA00244; UER00310.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Erythronate-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.290UniRule annotation)
    Gene namesi
    Name:pdxBUniRule annotation
    Ordered Locus Names:CBU_1812
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Erythronate-4-phosphate dehydrogenasePRO_0000075974Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_1812.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83AR8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0111.
    HOGENOMiHOG000234432.
    KOiK03473.
    OMAiSAPGCNA.
    OrthoDBiEOG6VXFC3.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    HAMAPiMF_01825. PdxB.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR020921. Erythronate-4-P_DHase.
    IPR024531. Erythronate-4-P_DHase_dimer.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    PF11890. DUF3410. 1 hit.
    [Graphical view]
    PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83AR8-1 [UniParc]FASTAAdd to Basket

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    MIKILADDRI PFVSELFGDF GELILKPGAH IQNRDLLAVN ALLTRSITSV    50
    DSALLEGTAV EFVGSATAGF DHIDSTWLKK QSIHWAYAPG ANATAVAEYV 100
    LHCVAYLHKK NLLPRKSATA AIIGVGHVGC VVSDRLRKIG FTVFHNDPPR 150
    AQLEKDFISV PLASLANVDL VCLHTPLVKT GNFPTYHLID NRFLKMLKPG 200
    SVLLNAGRGA VIDNNALLQC DHVITCLDVW ENEPTVNLQL LEKTTIATPH 250
    IAGYSKQAKL RATLMIYDAF LKYFHLSDTR RFSELQQLQE TMTLNIQDGR 300
    NAEDILLTLF DPGRESQRMR ETLAENPDQF EYLRRHFPLR NEFSAIQLTP 350
    TPSALLRKEL DDWGFK 366
    Length:366
    Mass (Da):40,969
    Last modified:April 13, 2004 - v2
    Checksum:iFC5F34670DCF8C1F
    GO

    Sequence cautioni

    The sequence AAO91305.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91305.1. Different initiation.
    RefSeqiNP_820791.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91305; AAO91305; CBU_1812.
    GeneIDi1209723.
    KEGGicbu:CBU_1812.
    PATRICi17932359. VBICoxBur82552_1798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91305.1 . Different initiation.
    RefSeqi NP_820791.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83AR8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91305 ; AAO91305 ; CBU_1812 .
    GeneIDi 1209723.
    KEGGi cbu:CBU_1812.
    PATRICi 17932359. VBICoxBur82552_1798.

    Phylogenomic databases

    eggNOGi COG0111.
    HOGENOMi HOG000234432.
    KOi K03473.
    OMAi SAPGCNA.
    OrthoDBi EOG6VXFC3.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00310 .
    BioCyci CBUR227377:GJ7S-1785-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    HAMAPi MF_01825. PdxB.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR020921. Erythronate-4-P_DHase.
    IPR024531. Erythronate-4-P_DHase_dimer.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    PF11890. DUF3410. 1 hit.
    [Graphical view ]
    PROSITEi PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiPDXB_COXBU
    AccessioniPrimary (citable) accession number: Q83AR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3