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Q83AR8

- PDXB_COXBU

UniProt

Q83AR8 - PDXB_COXBU

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Protein
Erythronate-4-phosphate dehydrogenase
Gene
pdxB, CBU_1812
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate By similarity.UniRule annotation

Catalytic activityi

4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461Substrate By similarity
Binding sitei67 – 671Substrate By similarity
Binding sitei147 – 1471NAD By similarity
Binding sitei175 – 1751NAD; via carbonyl oxygen By similarity
Active sitei208 – 2081 By similarity
Binding sitei228 – 2281NAD By similarity
Active sitei233 – 2331 By similarity
Active sitei250 – 2501Proton donor By similarity
Binding sitei253 – 2531NAD; via amide nitrogen By similarity
Binding sitei254 – 2541Substrate By similarity

GO - Molecular functioni

  1. 4-phosphoerythronate dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1785-MONOMER.
UniPathwayiUPA00244; UER00310.

Names & Taxonomyi

Protein namesi
Recommended name:
Erythronate-4-phosphate dehydrogenase (EC:1.1.1.290)
Gene namesi
Name:pdxB
Ordered Locus Names:CBU_1812
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Erythronate-4-phosphate dehydrogenaseUniRule annotation
PRO_0000075974Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1812.

Structurei

3D structure databases

ProteinModelPortaliQ83AR8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0111.
HOGENOMiHOG000234432.
KOiK03473.
OMAiSAPGCNA.
OrthoDBiEOG6VXFC3.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_01825. PdxB.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR020921. Erythronate-4-P_DHase.
IPR024531. Erythronate-4-P_DHase_dimer.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
PF11890. DUF3410. 1 hit.
[Graphical view]
PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83AR8-1 [UniParc]FASTAAdd to Basket

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MIKILADDRI PFVSELFGDF GELILKPGAH IQNRDLLAVN ALLTRSITSV    50
DSALLEGTAV EFVGSATAGF DHIDSTWLKK QSIHWAYAPG ANATAVAEYV 100
LHCVAYLHKK NLLPRKSATA AIIGVGHVGC VVSDRLRKIG FTVFHNDPPR 150
AQLEKDFISV PLASLANVDL VCLHTPLVKT GNFPTYHLID NRFLKMLKPG 200
SVLLNAGRGA VIDNNALLQC DHVITCLDVW ENEPTVNLQL LEKTTIATPH 250
IAGYSKQAKL RATLMIYDAF LKYFHLSDTR RFSELQQLQE TMTLNIQDGR 300
NAEDILLTLF DPGRESQRMR ETLAENPDQF EYLRRHFPLR NEFSAIQLTP 350
TPSALLRKEL DDWGFK 366
Length:366
Mass (Da):40,969
Last modified:April 13, 2004 - v2
Checksum:iFC5F34670DCF8C1F
GO

Sequence cautioni

The sequence AAO91305.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91305.1. Different initiation.
RefSeqiNP_820791.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91305; AAO91305; CBU_1812.
GeneIDi1209723.
KEGGicbu:CBU_1812.
PATRICi17932359. VBICoxBur82552_1798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91305.1 . Different initiation.
RefSeqi NP_820791.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83AR8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91305 ; AAO91305 ; CBU_1812 .
GeneIDi 1209723.
KEGGi cbu:CBU_1812.
PATRICi 17932359. VBICoxBur82552_1798.

Phylogenomic databases

eggNOGi COG0111.
HOGENOMi HOG000234432.
KOi K03473.
OMAi SAPGCNA.
OrthoDBi EOG6VXFC3.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00310 .
BioCyci CBUR227377:GJ7S-1785-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
HAMAPi MF_01825. PdxB.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR020921. Erythronate-4-P_DHase.
IPR024531. Erythronate-4-P_DHase_dimer.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
PF11890. DUF3410. 1 hit.
[Graphical view ]
PROSITEi PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiPDXB_COXBU
AccessioniPrimary (citable) accession number: Q83AR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 3, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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