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Q83AR8

- PDXB_COXBU

UniProt

Q83AR8 - PDXB_COXBU

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Protein

Erythronate-4-phosphate dehydrogenase

Gene

pdxB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.UniRule annotation

Catalytic activityi

4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461SubstrateUniRule annotation
Binding sitei67 – 671SubstrateUniRule annotation
Binding sitei147 – 1471NADUniRule annotation
Binding sitei175 – 1751NAD; via carbonyl oxygenUniRule annotation
Active sitei208 – 2081UniRule annotation
Binding sitei228 – 2281NADUniRule annotation
Active sitei233 – 2331UniRule annotation
Active sitei250 – 2501Proton donorUniRule annotation
Binding sitei253 – 2531NAD; via amide nitrogenUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation

GO - Molecular functioni

  1. 4-phosphoerythronate dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1785-MONOMER.
UniPathwayiUPA00244; UER00310.

Names & Taxonomyi

Protein namesi
Recommended name:
Erythronate-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.290UniRule annotation)
Gene namesi
Name:pdxBUniRule annotation
Ordered Locus Names:CBU_1812
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Erythronate-4-phosphate dehydrogenasePRO_0000075974Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1812.

Structurei

3D structure databases

ProteinModelPortaliQ83AR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0111.
HOGENOMiHOG000234432.
KOiK03473.
OMAiSAPGCNA.
OrthoDBiEOG6VXFC3.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_01825. PdxB.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR020921. Erythronate-4-P_DHase.
IPR024531. Erythronate-4-P_DHase_dimer.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
PF11890. DUF3410. 1 hit.
[Graphical view]
PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83AR8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKILADDRI PFVSELFGDF GELILKPGAH IQNRDLLAVN ALLTRSITSV
60 70 80 90 100
DSALLEGTAV EFVGSATAGF DHIDSTWLKK QSIHWAYAPG ANATAVAEYV
110 120 130 140 150
LHCVAYLHKK NLLPRKSATA AIIGVGHVGC VVSDRLRKIG FTVFHNDPPR
160 170 180 190 200
AQLEKDFISV PLASLANVDL VCLHTPLVKT GNFPTYHLID NRFLKMLKPG
210 220 230 240 250
SVLLNAGRGA VIDNNALLQC DHVITCLDVW ENEPTVNLQL LEKTTIATPH
260 270 280 290 300
IAGYSKQAKL RATLMIYDAF LKYFHLSDTR RFSELQQLQE TMTLNIQDGR
310 320 330 340 350
NAEDILLTLF DPGRESQRMR ETLAENPDQF EYLRRHFPLR NEFSAIQLTP
360
TPSALLRKEL DDWGFK
Length:366
Mass (Da):40,969
Last modified:April 13, 2004 - v2
Checksum:iFC5F34670DCF8C1F
GO

Sequence cautioni

The sequence AAO91305.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91305.1. Different initiation.
RefSeqiNP_820791.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91305; AAO91305; CBU_1812.
GeneIDi1209723.
KEGGicbu:CBU_1812.
PATRICi17932359. VBICoxBur82552_1798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91305.1 . Different initiation.
RefSeqi NP_820791.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83AR8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91305 ; AAO91305 ; CBU_1812 .
GeneIDi 1209723.
KEGGi cbu:CBU_1812.
PATRICi 17932359. VBICoxBur82552_1798.

Phylogenomic databases

eggNOGi COG0111.
HOGENOMi HOG000234432.
KOi K03473.
OMAi SAPGCNA.
OrthoDBi EOG6VXFC3.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00310 .
BioCyci CBUR227377:GJ7S-1785-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
HAMAPi MF_01825. PdxB.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR020921. Erythronate-4-P_DHase.
IPR024531. Erythronate-4-P_DHase_dimer.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
PF11890. DUF3410. 1 hit.
[Graphical view ]
PROSITEi PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiPDXB_COXBU
AccessioniPrimary (citable) accession number: Q83AR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3