Q83AQ4 (PSD_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	CBU_1826

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP-Rule MF_00662
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP-Rule MF_00662
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029645
	Chain	244 – 282	39	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029646
Sites
	Site	243 – 244	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	244	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83AQ4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A7416445E271A8A7	FASTA	282	31,941
	10 20 30 40 50 60 MTKLHKYLPQ RTLSKIVGWL ATREWGLLTQ WAIRLFIRHY GINMQEAQYP DIGHYPSFNA 70 80 90 100 110 120 FFTRYLKREL RPVVEEPRAI ASPVDGIISE MGQIKGENLI QAKNHHYTIT ALLGEDPSRA 130 140 150 160 170 180 SQFLDGDFFT AYLAPKNYHR IHMPLDGRLI EMIHIPGKLF SVNPASVQTV PRLFARNERA 190 200 210 220 230 240 VCLFETENGL MAVILVGAML VGSINTVWHG TVVPTAEGIA VHNYREKNIK FKRGEEIGHF 250 260 270 280 KMGSTVILLF PKNTIQWNPN CQPKGTICYG ENIGTVSLIE VA

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO91319.1.
RefSeq	NP_820805.1. NC_002971.3.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_1826.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO91319; AAO91319; CBU_1826.
GeneID	1209737.
KEGG	cbu:CBU_1826.
PATRIC	17932383. VBICoxBur82552_1810.
Phylogenomic databases
eggNOG	COG0688.
HOGENOM	HOG000282407.
KO	K01613.
OMA	YVPGRLF.
ProtClustDB	PRK00044.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-1799-MONOMER.
UniPathway	UPA00558; UER00616.
Family and domain databases
HAMAP	MF_00662. PS_decarb_type1.
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
PANTHER	PTHR10067. PTHR10067. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_COXBU

Accession

Primary (citable) accession number: Q83AQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program