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Protein

Phosphatidylserine decarboxylase proenzyme

Gene

psd

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.UniRule annotation

Cofactori

pyruvateUniRule annotationNote: Binds 1 pyruvoyl group covalently per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei243 – 2442Cleavage (non-hydrolytic)UniRule annotation

GO - Molecular functioni

  1. phosphatidylserine decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphatidylethanolamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1799-MONOMER.
UniPathwayiUPA00558; UER00616.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylserine decarboxylase proenzymeUniRule annotation (EC:4.1.1.65UniRule annotation)
Cleaved into the following 2 chains:
Phosphatidylserine decarboxylase alpha chainUniRule annotation
Phosphatidylserine decarboxylase beta chainUniRule annotation
Gene namesi
Name:psdUniRule annotation
Ordered Locus Names:CBU_1826
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Phosphatidylserine decarboxylase beta chainUniRule annotationPRO_0000029645Add
BLAST
Chaini244 – 28239Phosphatidylserine decarboxylase alpha chainUniRule annotationPRO_0000029646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei244 – 2441Pyruvic acid (Ser)UniRule annotation

Keywords - PTMi

Zymogen

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1826.

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0688.
HOGENOMiHOG000282407.
KOiK01613.
OMAiSMATVWH.
OrthoDBiEOG6B8XK4.

Family and domain databases

HAMAPiMF_00662. PS_decarb_type1.
InterProiIPR003817. PS_Dcarbxylase.
[Graphical view]
PANTHERiPTHR10067. PTHR10067. 1 hit.
PfamiPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00163. PS_decarb. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83AQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKLHKYLPQ RTLSKIVGWL ATREWGLLTQ WAIRLFIRHY GINMQEAQYP
60 70 80 90 100
DIGHYPSFNA FFTRYLKREL RPVVEEPRAI ASPVDGIISE MGQIKGENLI
110 120 130 140 150
QAKNHHYTIT ALLGEDPSRA SQFLDGDFFT AYLAPKNYHR IHMPLDGRLI
160 170 180 190 200
EMIHIPGKLF SVNPASVQTV PRLFARNERA VCLFETENGL MAVILVGAML
210 220 230 240 250
VGSINTVWHG TVVPTAEGIA VHNYREKNIK FKRGEEIGHF KMGSTVILLF
260 270 280
PKNTIQWNPN CQPKGTICYG ENIGTVSLIE VA
Length:282
Mass (Da):31,941
Last modified:June 1, 2003 - v1
Checksum:iA7416445E271A8A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91319.1.
RefSeqiNP_820805.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91319; AAO91319; CBU_1826.
GeneIDi1209737.
KEGGicbu:CBU_1826.
PATRICi17932383. VBICoxBur82552_1810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91319.1.
RefSeqiNP_820805.1. NC_002971.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO91319; AAO91319; CBU_1826.
GeneIDi1209737.
KEGGicbu:CBU_1826.
PATRICi17932383. VBICoxBur82552_1810.

Phylogenomic databases

eggNOGiCOG0688.
HOGENOMiHOG000282407.
KOiK01613.
OMAiSMATVWH.
OrthoDBiEOG6B8XK4.

Enzyme and pathway databases

UniPathwayiUPA00558; UER00616.
BioCyciCBUR227377:GJ7S-1799-MONOMER.

Family and domain databases

HAMAPiMF_00662. PS_decarb_type1.
InterProiIPR003817. PS_Dcarbxylase.
[Graphical view]
PANTHERiPTHR10067. PTHR10067. 1 hit.
PfamiPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00163. PS_decarb. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiPSD_COXBU
AccessioniPrimary (citable) accession number: Q83AQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.