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Protein

Peptide deformylase 2

Gene

def2

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101IronUniRule annotation1
Metal bindingi149IronUniRule annotation1
Active sitei150UniRule annotation1
Metal bindingi153IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1853-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 2UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 2UniRule annotation
Alternative name(s):
Polypeptide deformylase 2UniRule annotation
Gene namesi
Name:def2UniRule annotation
Ordered Locus Names:CBU_1879
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827771 – 209Peptide deformylase 2Add BLAST209

Proteomic databases

PRIDEiQ83AK6

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1879

Structurei

3D structure databases

ProteinModelPortaliQ83AK6
SMRiQ83AK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108RBJ Bacteria
COG0242 LUCA
HOGENOMiHOG000026809
KOiK01462
OMAiHREYSSV

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit

Sequencei

Sequence statusi: Complete.

Q83AK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVTTDSEN KAVLYKVASE VEIPLTKTTK EKIEAMRIFY KSFQGKAGFA
60 70 80 90 100
VPQVGLSERI ILVEQHLFDT TMAEETDEPT ILVNPSWRPI SDKKEWDIEG
110 120 130 140 150
CLSVPGKVGV VERYVHVELT AWLYHSDTEA LSKIKREYHR EYSSVLWQHE
160 170 180 190 200
IDHLEGKIYV DKAKLLLNEK DFYSFRQQLI ESGKIQSGMA LFDLGPLIYD

IVVKGEIPS
Length:209
Mass (Da):23,979
Last modified:June 1, 2003 - v1
Checksum:i079A74F285750B25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO91370.1
RefSeqiNP_820856.1, NC_002971.3
WP_010958511.1, NC_002971.4

Genome annotation databases

EnsemblBacteriaiAAO91370; AAO91370; CBU_1879
GeneIDi1209792
KEGGicbu:CBU_1879
PATRICifig|227377.7.peg.1861

Similar proteinsi

Entry informationi

Entry nameiDEF2_COXBU
AccessioniPrimary (citable) accession number: Q83AK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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