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Q83AK6

- DEF2_COXBU

UniProt

Q83AK6 - DEF2_COXBU

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Protein
Peptide deformylase 2
Gene
def2, CBU_1879
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron By similarity
Metal bindingi149 – 1491Iron By similarity
Active sitei150 – 1501 By similarity
Metal bindingi153 – 1531Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1855-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 2 (EC:3.5.1.88)
Short name:
PDF 2
Alternative name(s):
Polypeptide deformylase 2
Gene namesi
Name:def2
Ordered Locus Names:CBU_1879
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Peptide deformylase 2UniRule annotation
PRO_0000082777Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1879.

Structurei

3D structure databases

ProteinModelPortaliQ83AK6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000026809.
KOiK01462.
OMAiREYHREY.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83AK6-1 [UniParc]FASTAAdd to Basket

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MKIVTTDSEN KAVLYKVASE VEIPLTKTTK EKIEAMRIFY KSFQGKAGFA    50
VPQVGLSERI ILVEQHLFDT TMAEETDEPT ILVNPSWRPI SDKKEWDIEG 100
CLSVPGKVGV VERYVHVELT AWLYHSDTEA LSKIKREYHR EYSSVLWQHE 150
IDHLEGKIYV DKAKLLLNEK DFYSFRQQLI ESGKIQSGMA LFDLGPLIYD 200
IVVKGEIPS 209
Length:209
Mass (Da):23,979
Last modified:June 1, 2003 - v1
Checksum:i079A74F285750B25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91370.1.
RefSeqiNP_820856.1. NC_002971.3.
WP_010958511.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91370; AAO91370; CBU_1879.
GeneIDi1209792.
KEGGicbu:CBU_1879.
PATRICi17932489. VBICoxBur82552_1861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91370.1 .
RefSeqi NP_820856.1. NC_002971.3.
WP_010958511.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83AK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91370 ; AAO91370 ; CBU_1879 .
GeneIDi 1209792.
KEGGi cbu:CBU_1879.
PATRICi 17932489. VBICoxBur82552_1861.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000026809.
KOi K01462.
OMAi REYHREY.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1855-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiDEF2_COXBU
AccessioniPrimary (citable) accession number: Q83AK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi