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Q83AK6

- DEF2_COXBU

UniProt

Q83AK6 - DEF2_COXBU

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Protein

Peptide deformylase 2

Gene

def2

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe(2+) ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011IronUniRule annotation
Metal bindingi149 – 1491IronUniRule annotation
Active sitei150 – 1501UniRule annotation
Metal bindingi153 – 1531IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1855-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 2UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 2UniRule annotation
Alternative name(s):
Polypeptide deformylase 2UniRule annotation
Gene namesi
Name:def2UniRule annotation
Ordered Locus Names:CBU_1879
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Peptide deformylase 2PRO_0000082777Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1879.

Structurei

3D structure databases

ProteinModelPortaliQ83AK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000026809.
KOiK01462.
OMAiREYHREY.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83AK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIVTTDSEN KAVLYKVASE VEIPLTKTTK EKIEAMRIFY KSFQGKAGFA
60 70 80 90 100
VPQVGLSERI ILVEQHLFDT TMAEETDEPT ILVNPSWRPI SDKKEWDIEG
110 120 130 140 150
CLSVPGKVGV VERYVHVELT AWLYHSDTEA LSKIKREYHR EYSSVLWQHE
160 170 180 190 200
IDHLEGKIYV DKAKLLLNEK DFYSFRQQLI ESGKIQSGMA LFDLGPLIYD

IVVKGEIPS
Length:209
Mass (Da):23,979
Last modified:June 1, 2003 - v1
Checksum:i079A74F285750B25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91370.1.
RefSeqiNP_820856.1. NC_002971.3.
WP_010958511.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91370; AAO91370; CBU_1879.
GeneIDi1209792.
KEGGicbu:CBU_1879.
PATRICi17932489. VBICoxBur82552_1861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91370.1 .
RefSeqi NP_820856.1. NC_002971.3.
WP_010958511.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83AK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91370 ; AAO91370 ; CBU_1879 .
GeneIDi 1209792.
KEGGi cbu:CBU_1879.
PATRICi 17932489. VBICoxBur82552_1861.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000026809.
KOi K01462.
OMAi REYHREY.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1855-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiDEF2_COXBU
AccessioniPrimary (citable) accession number: Q83AK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3