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Q83AJ3

- AROK_COXBU

UniProt

Q83AJ3 - AROK_COXBU

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Protein

Shikimate kinase

Gene

aroK

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191MagnesiumUniRule annotation
Binding sitei37 – 371SubstrateUniRule annotation
Binding sitei61 – 611SubstrateUniRule annotation
Binding sitei83 – 831Substrate; via amide nitrogenUniRule annotation
Binding sitei123 – 1231ATPUniRule annotation
Binding sitei142 – 1421SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. shikimate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1867-MONOMER.
UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:CBU_1892
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Shikimate kinasePRO_0000237869Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1892.

Structurei

Secondary structure

1
179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115Combined sources
Helixi18 – 2912Combined sources
Beta strandi33 – 353Combined sources
Helixi36 – 449Combined sources
Helixi48 – 7326Combined sources
Beta strandi74 – 763Combined sources
Beta strandi78 – 803Combined sources
Helixi85 – 873Combined sources
Helixi89 – 9810Combined sources
Beta strandi99 – 1057Combined sources
Helixi108 – 1169Combined sources
Helixi129 – 14921Combined sources
Beta strandi151 – 1555Combined sources
Helixi161 – 17111Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TRFX-ray2.60A/B1-179[»]
ProteinModelPortaliQ83AJ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ83AJ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0703.
HOGENOMiHOG000032568.
KOiK00891.
OMAiADIPWIF.
OrthoDBiEOG6SJJGD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00109. Shikimate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
PRINTSiPR01100. SHIKIMTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83AJ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKNLTNIYL IGLMGAGKTS VGSQLAKLTK RILYDSDKEI EKRTGADIAW
60 70 80 90 100
IFEMEGEAGF RRREREMIEA LCKLDNIILA TGGGVVLDEK NRQQISETGV
110 120 130 140 150
VIYLTASIDT QLKRIGQKGE MRRPLFIKNN SKEKLQQLNE IRKPLYQAMA
160 170
DLVYPTDDLN PRQLATQILV DIKQTYSDL
Length:179
Mass (Da):20,335
Last modified:June 1, 2003 - v1
Checksum:iA47C31B7EF35941C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91383.1.
RefSeqiNP_820869.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91383; AAO91383; CBU_1892.
GeneIDi1209805.
KEGGicbu:CBU_1892.
PATRICi17932517. VBICoxBur82552_1875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91383.1 .
RefSeqi NP_820869.1. NC_002971.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TRF X-ray 2.60 A/B 1-179 [» ]
ProteinModelPortali Q83AJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91383 ; AAO91383 ; CBU_1892 .
GeneIDi 1209805.
KEGGi cbu:CBU_1892.
PATRICi 17932517. VBICoxBur82552_1875.

Phylogenomic databases

eggNOGi COG0703.
HOGENOMi HOG000032568.
KOi K00891.
OMAi ADIPWIF.
OrthoDBi EOG6SJJGD.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00088 .
BioCyci CBUR227377:GJ7S-1867-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q83AJ3.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00109. Shikimate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view ]
Pfami PF01202. SKI. 1 hit.
[Graphical view ]
PRINTSi PR01100. SHIKIMTKNASE.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiAROK_COXBU
AccessioniPrimary (citable) accession number: Q83AJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3