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Q83AJ3

- AROK_COXBU

UniProt

Q83AJ3 - AROK_COXBU

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Protein
Shikimate kinase
Gene
aroK, CBU_1892
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191Magnesium By similarity
Binding sitei37 – 371Substrate By similarity
Binding sitei61 – 611Substrate By similarity
Binding sitei83 – 831Substrate; via amide nitrogen By similarity
Binding sitei123 – 1231ATP By similarity
Binding sitei142 – 1421Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. shikimate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1867-MONOMER.
UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinase (EC:2.7.1.71)
Short name:
SK
Gene namesi
Name:aroK
Ordered Locus Names:CBU_1892
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Shikimate kinaseUniRule annotation
PRO_0000237869Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1892.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115
Helixi18 – 2912
Beta strandi33 – 353
Helixi36 – 449
Helixi48 – 7326
Beta strandi74 – 763
Beta strandi78 – 803
Helixi85 – 873
Helixi89 – 9810
Beta strandi99 – 1057
Helixi108 – 1169
Helixi129 – 14921
Beta strandi151 – 1555
Helixi161 – 17111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TRFX-ray2.60A/B1-179[»]
ProteinModelPortaliQ83AJ3.

Miscellaneous databases

EvolutionaryTraceiQ83AJ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.

Phylogenomic databases

eggNOGiCOG0703.
HOGENOMiHOG000032568.
KOiK00891.
OMAiADIPWIF.
OrthoDBiEOG6SJJGD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00109. Shikimate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
PRINTSiPR01100. SHIKIMTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83AJ3-1 [UniParc]FASTAAdd to Basket

« Hide

MKKNLTNIYL IGLMGAGKTS VGSQLAKLTK RILYDSDKEI EKRTGADIAW    50
IFEMEGEAGF RRREREMIEA LCKLDNIILA TGGGVVLDEK NRQQISETGV 100
VIYLTASIDT QLKRIGQKGE MRRPLFIKNN SKEKLQQLNE IRKPLYQAMA 150
DLVYPTDDLN PRQLATQILV DIKQTYSDL 179
Length:179
Mass (Da):20,335
Last modified:June 1, 2003 - v1
Checksum:iA47C31B7EF35941C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91383.1.
RefSeqiNP_820869.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91383; AAO91383; CBU_1892.
GeneIDi1209805.
KEGGicbu:CBU_1892.
PATRICi17932517. VBICoxBur82552_1875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91383.1 .
RefSeqi NP_820869.1. NC_002971.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TRF X-ray 2.60 A/B 1-179 [» ]
ProteinModelPortali Q83AJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91383 ; AAO91383 ; CBU_1892 .
GeneIDi 1209805.
KEGGi cbu:CBU_1892.
PATRICi 17932517. VBICoxBur82552_1875.

Phylogenomic databases

eggNOGi COG0703.
HOGENOMi HOG000032568.
KOi K00891.
OMAi ADIPWIF.
OrthoDBi EOG6SJJGD.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00088 .
BioCyci CBUR227377:GJ7S-1867-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q83AJ3.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00109. Shikimate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view ]
Pfami PF01202. SKI. 1 hit.
[Graphical view ]
PRINTSi PR01100. SHIKIMTKNASE.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiAROK_COXBU
AccessioniPrimary (citable) accession number: Q83AJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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