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Q83AJ3

- AROK_COXBU

UniProt

Q83AJ3 - AROK_COXBU

Protein

Shikimate kinase

Gene

aroK

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

    Catalytic activityi

    ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi19 – 191MagnesiumUniRule annotation
    Binding sitei37 – 371SubstrateUniRule annotation
    Binding sitei61 – 611SubstrateUniRule annotation
    Binding sitei83 – 831Substrate; via amide nitrogenUniRule annotation
    Binding sitei123 – 1231ATPUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 206ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. shikimate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1867-MONOMER.
    UniPathwayiUPA00053; UER00088.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
    Short name:
    SKUniRule annotation
    Gene namesi
    Name:aroKUniRule annotation
    Ordered Locus Names:CBU_1892
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Shikimate kinasePRO_0000237869Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_1892.

    Structurei

    Secondary structure

    1
    179
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 115
    Helixi18 – 2912
    Beta strandi33 – 353
    Helixi36 – 449
    Helixi48 – 7326
    Beta strandi74 – 763
    Beta strandi78 – 803
    Helixi85 – 873
    Helixi89 – 9810
    Beta strandi99 – 1057
    Helixi108 – 1169
    Helixi129 – 14921
    Beta strandi151 – 1555
    Helixi161 – 17111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TRFX-ray2.60A/B1-179[»]
    ProteinModelPortaliQ83AJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ83AJ3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0703.
    HOGENOMiHOG000032568.
    KOiK00891.
    OMAiADIPWIF.
    OrthoDBiEOG6SJJGD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00109. Shikimate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    IPR023000. Shikimate_kinase_CS.
    [Graphical view]
    PfamiPF01202. SKI. 1 hit.
    [Graphical view]
    PRINTSiPR01100. SHIKIMTKNASE.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS01128. SHIKIMATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83AJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKNLTNIYL IGLMGAGKTS VGSQLAKLTK RILYDSDKEI EKRTGADIAW    50
    IFEMEGEAGF RRREREMIEA LCKLDNIILA TGGGVVLDEK NRQQISETGV 100
    VIYLTASIDT QLKRIGQKGE MRRPLFIKNN SKEKLQQLNE IRKPLYQAMA 150
    DLVYPTDDLN PRQLATQILV DIKQTYSDL 179
    Length:179
    Mass (Da):20,335
    Last modified:June 1, 2003 - v1
    Checksum:iA47C31B7EF35941C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91383.1.
    RefSeqiNP_820869.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91383; AAO91383; CBU_1892.
    GeneIDi1209805.
    KEGGicbu:CBU_1892.
    PATRICi17932517. VBICoxBur82552_1875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91383.1 .
    RefSeqi NP_820869.1. NC_002971.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TRF X-ray 2.60 A/B 1-179 [» ]
    ProteinModelPortali Q83AJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1892.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91383 ; AAO91383 ; CBU_1892 .
    GeneIDi 1209805.
    KEGGi cbu:CBU_1892.
    PATRICi 17932517. VBICoxBur82552_1875.

    Phylogenomic databases

    eggNOGi COG0703.
    HOGENOMi HOG000032568.
    KOi K00891.
    OMAi ADIPWIF.
    OrthoDBi EOG6SJJGD.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00088 .
    BioCyci CBUR227377:GJ7S-1867-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q83AJ3.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00109. Shikimate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    IPR023000. Shikimate_kinase_CS.
    [Graphical view ]
    Pfami PF01202. SKI. 1 hit.
    [Graphical view ]
    PRINTSi PR01100. SHIKIMTKNASE.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS01128. SHIKIMATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiAROK_COXBU
    AccessioniPrimary (citable) accession number: Q83AJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3