Q83AG1 (ATP6_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit a

Alternative name(s):
ATP synthase F0 sector subunit a
F-ATPase subunit 6

Gene names

Name:	atpB
Ordered Locus Names:	CBU_1939

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity. HAMAP-Rule MF_01393
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01393.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	proton-transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	ATP synthase subunit a HAMAP-Rule MF_01393		PRO_0000362277
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83AG1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 677500A8E14C9431	FASTA	264	29,866
	10 20 30 40 50 60 MYAQPKLTSA EYVQHHMSHW KLNLHNFTFT DGGFWTLNLD TLIISVVLGA LFILIFYIVA 70 80 90 100 110 120 RRATASVPGK WQNAIEMAVE AVDGTVKDSF HGDRSLVAPL ALTIFIWVFL MNFMDLVPVD 130 140 150 160 170 180 LIPRLFQMGG VEHFKAVPTA DPTLTFAMSI TVFVLVIFYN FKMKGAIGLG KEVLSRPFGW 190 200 210 220 230 240 YLMPINVIFR LIDEGVKPIS LALRLFGNLF AGELIFILIA LLPWWSQFTL GMVWTLFHLL 250 260 VITVQAFIFM MLTVVYISLA AESH

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO91429.1.
RefSeq	NP_820915.1. NC_002971.3.
3D structure databases
ProteinModelPortal	Q83AG1.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_1939.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO91429; AAO91429; CBU_1939.
GeneID	1209852.
KEGG	cbu:CBU_1939.
PATRIC	17932615. VBICoxBur82552_1924.
Phylogenomic databases
eggNOG	COG0356.
HOGENOM	HOG000253872.
KO	K02108.
OMA	YIGEHIF.
ProtClustDB	PRK05815.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-1913-MONOMER.
Family and domain databases
Gene3D	1.20.120.220. 1 hit.
HAMAP	MF_01393. ATP_synth_a_bact.
InterPro	IPR000568. ATPase_F0-cplx_asu. IPR023011. ATPase_F0-cplx_asu_AS. [Graphical view]
PANTHER	PTHR11410. PTHR11410. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
SUPFAM	SSF81336. ATPase_F0_A. 1 hit.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_COXBU

Accession

Primary (citable) accession number: Q83AG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program