Q83AC6 (LPTD_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LPS-assembly protein LptD

Alternative name(s):
Organic solvent tolerance protein

Gene names

Name:	lptD
Synonyms:	imp, ostA
Ordered Locus Names:	CBU_1978

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	870 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis By similarity. HAMAP-Rule MF_01411
Subunit structure	Forms a high-molecular-weight complex in the outer membrane By similarity.
Subcellular location	Cell outer membrane By similarity.
Sequence similarities	Belongs to the LptD family.

Ontologies

Keywords
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Gram-negative-bacterium-type cell outer membrane assembly Inferred from electronic annotation. Source: HAMAP lipopolysaccharide transport Inferred from electronic annotation. Source: InterPro response to organic substance Inferred from electronic annotation. Source: InterPro
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 870	845	LPS-assembly protein LptD HAMAP-Rule MF_01411		PRO_0000281600

Sequences

	Sequence		Length	Mass (Da)
	Q83AC6 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 2FD4AC39F0C2DAF8	FASTA	870	99,077
	10 20 30 40 50 60 MKQGKSFIFY CLVLLLCGFQ QLSSAVTASI AKAIKTTDRK QRVSETLPTG LSYRRFYQHI 70 80 90 100 110 120 AHLLGWVPAP DLVCRGYFKE PLILTEHPHP GPATKEPAIV TAKGPSMVTA QGVSILRKDV 130 140 150 160 170 180 VVTQPGRIVE ADKAYIYRDS KTGHVTKIIL IGHVRLHEAD KRIVADKGTL TLYPKTAILM 190 200 210 220 230 240 NAAYHIYNGE PYFYKFKYPF DAWGIAKHAV RDASNVITLR HATYSTCKPT APAWSMSATT 250 260 270 280 290 300 LVLNRNTHRG EAYNMLLHIG RVPIFYFPYF NFPIDNYRKT GFLIPYAGHS SSSGWFFALP 310 320 330 340 350 360 FYWNMAPNYD LTLTPEFMSE RGLNLQSLFR FLSTKSSGTI YLNYLPNDKV FQQFRETTLS 370 380 390 400 410 420 KFPPSVLAEH PVFIPYVDKL KKMKNQRAFF SMNETTLFNS EWSSRVILNY VTDPYFFQDL 430 440 450 460 470 480 GGQLGGSSLA NQLLNQIDLQ YNGLHWQFMG MLQAYQTLHL ISQWTTPALD QYSRLPDFNI 490 500 510 520 530 540 VGYYPDIARH VDFNFNAEAV NFDYRSDFVP DKPRGQRFHM RPGISFPFYF ASGYIIPQLW 550 560 570 580 590 600 ADATAYNITH FQPGQAHTSS RLLPIFDIDS GLYFDRNFHL GHRSFIQTLE PRFFYLYVPY 610 620 630 640 650 660 QNQDRFPNFD TVLLPFSFEQ LFALNQFTGN DRLQNANQAS FALTSRVLDA QNGSPILTAN 670 680 690 700 710 720 VGFIYYLENQ RVCLTPGCTP SNYHYSPIIG ELTFYPFPYW SFTGSLAWDP NLGQTNNTSV 730 740 750 760 770 780 ELAYNNGGKK ADIRYLFVHG NEDSIVTPTT LIVPGNAYSQ NTNHVISSGA WPLLKKWNAV 790 800 810 820 830 840 GYWDYNITER RTDVYSIGVQ YNTCCWALSF SIRRTYAGLK VDPNGALQRQ YDTAYGFELQ 850 860 870 LKGLGNLGTA PISTVTVLDA MNNGVSNDVR

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO91467.1.
RefSeq	NP_820953.1. NC_002971.3.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_1978.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO91467; AAO91467; CBU_1978.
GeneID	1209891.
KEGG	cbu:CBU_1978.
PATRIC	17932699. VBICoxBur82552_1966.
Phylogenomic databases
eggNOG	COG1452.
HOGENOM	HOG000027335.
KO	K04744.
OMA	VDNAEYV.
ProtClustDB	CLSK915165.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-1952-MONOMER.
Family and domain databases
HAMAP	MF_01411. OstA.
InterPro	IPR020889. LipoPS_assembly_LptD. IPR007543. OstA_C. [Graphical view]
Pfam	PF04453. OstA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPTD_COXBU

Accession

Primary (citable) accession number: Q83AC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program