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Q83AC2

- RSMA_COXBU

UniProt

Q83AC2 - RSMA_COXBU

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Protein
Ribosomal RNA small subunit methyltransferase A
Gene
rsmA, ksgA, CBU_1982
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits By similarity.UniRule annotation

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei15 – 151S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei40 – 401S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei61 – 611S-adenosyl-L-methionine By similarity
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Binding sitei106 – 1061S-adenosyl-L-methionine By similarity

GO - Molecular functioni

  1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
  2. RNA binding Source: UniProtKB-KW
  3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1955-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA small subunit methyltransferase A (EC:2.1.1.182)
    Alternative name(s):
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase
    16S rRNA dimethyladenosine transferase
    16S rRNA dimethylase
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
    Gene namesi
    Name:rsmA
    Synonyms:ksgA
    Ordered Locus Names:CBU_1982
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm Reviewed prediction UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Ribosomal RNA small subunit methyltransferase AUniRule annotation
    PRO_0000101520Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_1982.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi18 – 2811
    Beta strandi35 – 395
    Turni42 – 465
    Helixi47 – 504
    Turni51 – 533
    Beta strandi54 – 618
    Helixi64 – 7411
    Beta strandi80 – 856
    Turni87 – 893
    Helixi92 – 943
    Beta strandi101 – 1066
    Helixi109 – 12113
    Helixi122 – 1254
    Beta strandi126 – 1349
    Helixi135 – 1417
    Helixi152 – 1609
    Beta strandi161 – 1699
    Helixi171 – 1733
    Beta strandi174 – 1763
    Beta strandi182 – 1898
    Helixi200 – 21213
    Helixi218 – 2214
    Turni222 – 2254
    Helixi228 – 2303
    Helixi232 – 2343
    Helixi242 – 2443
    Helixi247 – 25711

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TQSX-ray1.98A/B/C/D4-258[»]
    ProteinModelPortaliQ83AC2.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0030.
    HOGENOMiHOG000227962.
    KOiK02528.
    OMAiDHVMVEI.
    OrthoDBiEOG66F08Z.

    Family and domain databases

    Gene3Di1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPiMF_00607. 16SrRNA_methyltr_A.
    InterProiIPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11727. PTHR11727. 1 hit.
    PfamiPF00398. RrnaAD. 1 hit.
    [Graphical view]
    SMARTiSM00650. rADc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00755. ksgA. 1 hit.
    PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
    PS51689. SAM_RNA_A_N6_MT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83AC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKMPMRKRF GQHFLHDSFV LQKIVSAIHP QKTDTLVEIG PGRGALTDYL    50
    LTECDNLALV EIDRDLVAFL QKKYNQQKNI TIYQNDALQF DFSSVKTDKP 100
    LRVVGNLPYN ISTPLLFHLF SQIHCIEDMH FMLQKEVVRR ITAEVGSHDY 150
    GRLSVMAQYF CDNTYLFTVS PQAFTPPPRV ESAIIRLIPR HNFTPVAKNL 200
    DQLSHVVKEA FSYRRKTVGN ALKKLINPSQ WPLLEINPQL RPQELTVEDF 250
    VKISNILN 258
    Length:258
    Mass (Da):29,779
    Last modified:December 16, 2008 - v2
    Checksum:i40C0F96B085DFD2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91471.2.
    RefSeqiNP_820957.2. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91471; AAO91471; CBU_1982.
    GeneIDi1209895.
    KEGGicbu:CBU_1982.
    PATRICi17932705. VBICoxBur82552_1969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91471.2 .
    RefSeqi NP_820957.2. NC_002971.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TQS X-ray 1.98 A/B/C/D 4-258 [» ]
    ProteinModelPortali Q83AC2.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91471 ; AAO91471 ; CBU_1982 .
    GeneIDi 1209895.
    KEGGi cbu:CBU_1982.
    PATRICi 17932705. VBICoxBur82552_1969.

    Phylogenomic databases

    eggNOGi COG0030.
    HOGENOMi HOG000227962.
    KOi K02528.
    OMAi DHVMVEI.
    OrthoDBi EOG66F08Z.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1955-MONOMER.

    Family and domain databases

    Gene3Di 1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPi MF_00607. 16SrRNA_methyltr_A.
    InterProi IPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11727. PTHR11727. 1 hit.
    Pfami PF00398. RrnaAD. 1 hit.
    [Graphical view ]
    SMARTi SM00650. rADc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00755. ksgA. 1 hit.
    PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
    PS51689. SAM_RNA_A_N6_MT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiRSMA_COXBU
    AccessioniPrimary (citable) accession number: Q83AC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 4, 2003
    Last sequence update: December 16, 2008
    Last modified: June 11, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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