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Q83AC2

- RSMA_COXBU

UniProt

Q83AC2 - RSMA_COXBU

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Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei15 – 151S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei40 – 401S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei61 – 611S-adenosyl-L-methionineUniRule annotation
Binding sitei86 – 861S-adenosyl-L-methionineUniRule annotation
Binding sitei106 – 1061S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
  2. RNA binding Source: UniProtKB-KW
  3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1955-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
Alternative name(s):
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
16S rRNA dimethyladenosine transferaseUniRule annotation
16S rRNA dimethylaseUniRule annotation
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotation
Ordered Locus Names:CBU_1982
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Ribosomal RNA small subunit methyltransferase APRO_0000101520Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1982.

Structurei

Secondary structure

1
258
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi18 – 2811Combined sources
Beta strandi35 – 395Combined sources
Turni42 – 465Combined sources
Helixi47 – 504Combined sources
Turni51 – 533Combined sources
Beta strandi54 – 618Combined sources
Helixi64 – 7411Combined sources
Beta strandi80 – 856Combined sources
Turni87 – 893Combined sources
Helixi92 – 943Combined sources
Beta strandi101 – 1066Combined sources
Helixi109 – 12113Combined sources
Helixi122 – 1254Combined sources
Beta strandi126 – 1349Combined sources
Helixi135 – 1417Combined sources
Helixi152 – 1609Combined sources
Beta strandi161 – 1699Combined sources
Helixi171 – 1733Combined sources
Beta strandi174 – 1763Combined sources
Beta strandi182 – 1898Combined sources
Helixi200 – 21213Combined sources
Helixi218 – 2214Combined sources
Turni222 – 2254Combined sources
Helixi228 – 2303Combined sources
Helixi232 – 2343Combined sources
Helixi242 – 2443Combined sources
Helixi247 – 25711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TQSX-ray1.98A/B/C/D4-258[»]
ProteinModelPortaliQ83AC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0030.
HOGENOMiHOG000227962.
KOiK02528.
OMAiDHVMVEI.
OrthoDBiEOG66F08Z.

Family and domain databases

Gene3Di1.10.8.100. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A.
InterProiIPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR001737. rRNA_Ade_methylase_transferase.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83AC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKMPMRKRF GQHFLHDSFV LQKIVSAIHP QKTDTLVEIG PGRGALTDYL
60 70 80 90 100
LTECDNLALV EIDRDLVAFL QKKYNQQKNI TIYQNDALQF DFSSVKTDKP
110 120 130 140 150
LRVVGNLPYN ISTPLLFHLF SQIHCIEDMH FMLQKEVVRR ITAEVGSHDY
160 170 180 190 200
GRLSVMAQYF CDNTYLFTVS PQAFTPPPRV ESAIIRLIPR HNFTPVAKNL
210 220 230 240 250
DQLSHVVKEA FSYRRKTVGN ALKKLINPSQ WPLLEINPQL RPQELTVEDF

VKISNILN
Length:258
Mass (Da):29,779
Last modified:December 16, 2008 - v2
Checksum:i40C0F96B085DFD2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91471.2.
RefSeqiNP_820957.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91471; AAO91471; CBU_1982.
GeneIDi1209895.
KEGGicbu:CBU_1982.
PATRICi17932705. VBICoxBur82552_1969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91471.2 .
RefSeqi NP_820957.2. NC_002971.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TQS X-ray 1.98 A/B/C/D 4-258 [» ]
ProteinModelPortali Q83AC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1982.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91471 ; AAO91471 ; CBU_1982 .
GeneIDi 1209895.
KEGGi cbu:CBU_1982.
PATRICi 17932705. VBICoxBur82552_1969.

Phylogenomic databases

eggNOGi COG0030.
HOGENOMi HOG000227962.
KOi K02528.
OMAi DHVMVEI.
OrthoDBi EOG66F08Z.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1955-MONOMER.

Family and domain databases

Gene3Di 1.10.8.100. 1 hit.
3.40.50.150. 1 hit.
HAMAPi MF_00607. 16SrRNA_methyltr_A.
InterProi IPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR001737. rRNA_Ade_methylase_transferase.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR11727. PTHR11727. 1 hit.
Pfami PF00398. RrnaAD. 1 hit.
[Graphical view ]
SMARTi SM00650. rADc. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00755. ksgA. 1 hit.
PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiRSMA_COXBU
AccessioniPrimary (citable) accession number: Q83AC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: December 16, 2008
Last modified: November 26, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3