Q83AB7 (APAH_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	CBU_1987

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP-Rule MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP-Rule MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP-Rule MF_00199		PRO_0000197987

Sequences

	Sequence		Length	Mass (Da)
	Q83AB7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 27FB606C6A0D9765	FASTA	291	33,300
	10 20 30 40 50 60 MDARAINSRE KADLKYPRNT YIIGDVQGCY RELQELLELI QFDSTKDRLG FVGDLVNRGP 70 80 90 100 110 120 NSLEVLRFLK SLSSPLIVLG NHDLYLLILG YGLMPEDSYE HTLHAVLQAP DKLELLEWLR 130 140 150 160 170 180 HSPLIRYEKS LSAVLVHAGL PPQWNIKESI LHAEEISTAL KGPHYLAFLK NLFGNEPSQW 190 200 210 220 230 240 KEDLEGQDRL RYICNAFTRM RFCDAKGHLD LESEGKTNQA PSRFRPWFEW RNPQEDNVDI 250 260 270 280 290 VFGHWAALNG QSSAPHTHAL DTGCAWGYKL TAINLKTKER FSVPCQSALR M

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO91476.1.
RefSeq	NP_820962.1. NC_002971.3.
3D structure databases
ProteinModelPortal	Q83AB7.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_1987.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO91476; AAO91476; CBU_1987.
GeneID	1209900.
KEGG	cbu:CBU_1987.
PATRIC	17932715. VBICoxBur82552_1974.
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HOG000251871.
KO	K01525.
OMA	WLRHQPL.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-1960-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH.
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_COXBU

Accession

Primary (citable) accession number: Q83AB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program