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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64Substrate1
Binding sitei139Substrate1
Binding sitei164Substrate1
Binding sitei194Substrate1
Binding sitei198Substrate1
Binding sitei199NAD1
Binding sitei251NAD1
Binding sitei286NAD1
Binding sitei352NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi165 – 167NAD3
Nucleotide bindingi228 – 233NAD6
Nucleotide bindingi307 – 309NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name:
AdoHcyase
Gene namesi
Name:ahcY
Ordered Locus Names:CBU_2031
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169611 – 438AdenosylhomocysteinaseAdd BLAST438

Proteomic databases

PRIDEiQ83A77.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_2031.

Structurei

3D structure databases

ProteinModelPortaliQ83A77.
SMRiQ83A77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiTGNRDII.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 2 hits.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83A77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENDMETATM TQDYHIANIN LADWGRKEIE IAETEMPGLM ALRKKYKNAK
60 70 80 90 100
PLKGARIAGC IHMTIQTAVL IETLMLLGAE VRWSSCNIFS TQDHAAAALA
110 120 130 140 150
QKGIPIFAWK GETEEEYWRC IASTLEGPKG WTPNLLLDDG GDLTAHTLQK
160 170 180 190 200
HPELCQNIRG VSEETTTGVH RLYRMLKEGS LKFPAINVND SVTKSKFDNL
210 220 230 240 250
YGCRESLIDS IKRATDVMIA GKRVVVCGYG DVGKGCAQSL RAYGATVYIT
260 270 280 290 300
EIDPICALQA AMEGYRVVTM DEMADSADIF VTATGNTDII THEHMLKMKD
310 320 330 340 350
QAIVCNIGHF DNEIDIASLQ DYQWMNIKPQ VDQVIFPDGK RLTVLAQGRL
360 370 380 390 400
VNLGCATGHP SFVMSNSFTN QVLAQIELWQ YPEKYPIGVY VLPKHLDEEV
410 420 430
ARLHLERVGG KLTTLTEKQA DYIGVDPEGP FKSEHYRY
Length:438
Mass (Da):48,868
Last modified:December 16, 2008 - v2
Checksum:iEF9BC88F62DA390F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91518.2.
RefSeqiNP_821004.2. NC_002971.3.
WP_010958614.1. NZ_CCYB01000066.1.

Genome annotation databases

EnsemblBacteriaiAAO91518; AAO91518; CBU_2031.
GeneIDi1209944.
KEGGicbu:CBU_2031.
PATRICifig|227377.7.peg.2024.

Similar proteinsi

Entry informationi

Entry nameiSAHH_COXBU
AccessioniPrimary (citable) accession number: Q83A77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 16, 2008
Last modified: October 25, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families