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Q83A37

- HEM3_COXBU

UniProt

Q83A37 - HEM3_COXBU

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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

Binds 1 dipyrromethane group covalently.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-pyrromethane cofactor linkage Source: InterPro
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-2040-MONOMER.
UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Short name:
HMBSUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotation
Ordered Locus Names:CBU_2074
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Porphobilinogen deaminasePRO_0000142931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

Proteomic databases

PRIDEiQ83A37.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_2074.

Structurei

3D structure databases

ProteinModelPortaliQ83A37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0181.
HOGENOMiHOG000228587.
KOiK01749.
OMAiGIECRTD.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83A37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKKRSILIV TRKSPLALWQ AEFVKQQIEN SHPHLACQIL GCTTQGDRLT
60 70 80 90 100
TEKLVDSGGK DLFVKDLQKA LLNRDADIAV HSIKDMSACD GPELMVGAFI
110 120 130 140 150
RREDPRDVLI VKGELSTLPP HAVIGTSSPR RQCQLKKFQP GCKIKEIRGN
160 170 180 190 200
VGTRLAKLDA GHYEAIVLAA AGLKRLGLEN RIHYYFDPHE FIPAIGQGAI
210 220 230 240 250
GVECRSDDHE MQTLLKSLDH RETRLCVTAE RAVNEKLGGD CFTPIAAHAI
260 270 280 290 300
IKNDQLSLFA MLGKIDGRVI IRATEIGNSE EAKRIGFKVA SQLLEQGGDS

LLRELKQ
Length:307
Mass (Da):33,927
Last modified:June 1, 2003 - v1
Checksum:i57BDF5C4F3ACDE88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91558.1.
RefSeqiNP_821044.1. NC_002971.3.
WP_010958635.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91558; AAO91558; CBU_2074.
GeneIDi1209987.
KEGGicbu:CBU_2074.
PATRICi17932895. VBICoxBur82552_2064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91558.1 .
RefSeqi NP_821044.1. NC_002971.3.
WP_010958635.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83A37.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_2074.

Proteomic databases

PRIDEi Q83A37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91558 ; AAO91558 ; CBU_2074 .
GeneIDi 1209987.
KEGGi cbu:CBU_2074.
PATRICi 17932895. VBICoxBur82552_2064.

Phylogenomic databases

eggNOGi COG0181.
HOGENOMi HOG000228587.
KOi K01749.
OMAi GIECRTD.
OrthoDBi EOG6HB9Z6.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00319 .
BioCyci CBUR227377:GJ7S-2040-MONOMER.

Family and domain databases

Gene3Di 3.30.160.40. 1 hit.
HAMAPi MF_00260. Porphobil_deam.
InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view ]
PANTHERi PTHR11557. PTHR11557. 1 hit.
Pfami PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSi PR00151. PORPHBDMNASE.
SUPFAMi SSF54782. SSF54782. 1 hit.
TIGRFAMsi TIGR00212. hemC. 1 hit.
PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiHEM3_COXBU
AccessioniPrimary (citable) accession number: Q83A37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3