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Q83A37

- HEM3_COXBU

UniProt

Q83A37 - HEM3_COXBU

Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

    Catalytic activityi

    4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

    Cofactori

    Binds 1 dipyrromethane group covalently.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-pyrromethane cofactor linkage Source: InterPro
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-2040-MONOMER.
    UniPathwayiUPA00251; UER00319.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
    Short name:
    PBGUniRule annotation
    Alternative name(s):
    Hydroxymethylbilane synthaseUniRule annotation
    Short name:
    HMBSUniRule annotation
    Pre-uroporphyrinogen synthaseUniRule annotation
    Gene namesi
    Name:hemCUniRule annotation
    Ordered Locus Names:CBU_2074
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Porphobilinogen deaminasePRO_0000142931Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei241 – 2411S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

    Proteomic databases

    PRIDEiQ83A37.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_2074.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83A37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMBS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0181.
    HOGENOMiHOG000228587.
    KOiK01749.
    OMAiGIECRTD.
    OrthoDBiEOG6HB9Z6.

    Family and domain databases

    Gene3Di3.30.160.40. 1 hit.
    HAMAPiMF_00260. Porphobil_deam.
    InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view]
    PANTHERiPTHR11557. PTHR11557. 1 hit.
    PfamiPF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSiPR00151. PORPHBDMNASE.
    SUPFAMiSSF54782. SSF54782. 1 hit.
    TIGRFAMsiTIGR00212. hemC. 1 hit.
    PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83A37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKKRSILIV TRKSPLALWQ AEFVKQQIEN SHPHLACQIL GCTTQGDRLT    50
    TEKLVDSGGK DLFVKDLQKA LLNRDADIAV HSIKDMSACD GPELMVGAFI 100
    RREDPRDVLI VKGELSTLPP HAVIGTSSPR RQCQLKKFQP GCKIKEIRGN 150
    VGTRLAKLDA GHYEAIVLAA AGLKRLGLEN RIHYYFDPHE FIPAIGQGAI 200
    GVECRSDDHE MQTLLKSLDH RETRLCVTAE RAVNEKLGGD CFTPIAAHAI 250
    IKNDQLSLFA MLGKIDGRVI IRATEIGNSE EAKRIGFKVA SQLLEQGGDS 300
    LLRELKQ 307
    Length:307
    Mass (Da):33,927
    Last modified:June 1, 2003 - v1
    Checksum:i57BDF5C4F3ACDE88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91558.1.
    RefSeqiNP_821044.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91558; AAO91558; CBU_2074.
    GeneIDi1209987.
    KEGGicbu:CBU_2074.
    PATRICi17932895. VBICoxBur82552_2064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91558.1 .
    RefSeqi NP_821044.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83A37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_2074.

    Proteomic databases

    PRIDEi Q83A37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91558 ; AAO91558 ; CBU_2074 .
    GeneIDi 1209987.
    KEGGi cbu:CBU_2074.
    PATRICi 17932895. VBICoxBur82552_2064.

    Phylogenomic databases

    eggNOGi COG0181.
    HOGENOMi HOG000228587.
    KOi K01749.
    OMAi GIECRTD.
    OrthoDBi EOG6HB9Z6.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00319 .
    BioCyci CBUR227377:GJ7S-2040-MONOMER.

    Family and domain databases

    Gene3Di 3.30.160.40. 1 hit.
    HAMAPi MF_00260. Porphobil_deam.
    InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view ]
    PANTHERi PTHR11557. PTHR11557. 1 hit.
    Pfami PF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSi PR00151. PORPHBDMNASE.
    SUPFAMi SSF54782. SSF54782. 1 hit.
    TIGRFAMsi TIGR00212. hemC. 1 hit.
    PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiHEM3_COXBU
    AccessioniPrimary (citable) accession number: Q83A37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3