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Q83A37 (HEM3_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Porphobilinogen deaminase

Short name=PBG
EC=2.5.1.61
Alternative name(s):
Hydroxymethylbilane synthase
Short name=HMBS
Pre-uroporphyrinogen synthase
Gene names
Name:hemC
Ordered Locus Names:CBU_2074
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps By similarity. HAMAP-Rule MF_00260

Catalytic activity

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. HAMAP-Rule MF_00260

Cofactor

Binds 1 dipyrromethane group covalently By similarity. HAMAP-Rule MF_00260

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. HAMAP-Rule MF_00260

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00260

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group By similarity.

Sequence similarities

Belongs to the HMBS family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpeptidyl-pyrromethane cofactor linkage

Inferred from electronic annotation. Source: InterPro

protoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionhydroxymethylbilane synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Porphobilinogen deaminase HAMAP-Rule MF_00260
PRO_0000142931

Amino acid modifications

Modified residue2411S-(dipyrrolylmethanemethyl)cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83A37 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 57BDF5C4F3ACDE88

FASTA30733,927
        10         20         30         40         50         60 
MIKKRSILIV TRKSPLALWQ AEFVKQQIEN SHPHLACQIL GCTTQGDRLT TEKLVDSGGK 

        70         80         90        100        110        120 
DLFVKDLQKA LLNRDADIAV HSIKDMSACD GPELMVGAFI RREDPRDVLI VKGELSTLPP 

       130        140        150        160        170        180 
HAVIGTSSPR RQCQLKKFQP GCKIKEIRGN VGTRLAKLDA GHYEAIVLAA AGLKRLGLEN 

       190        200        210        220        230        240 
RIHYYFDPHE FIPAIGQGAI GVECRSDDHE MQTLLKSLDH RETRLCVTAE RAVNEKLGGD 

       250        260        270        280        290        300 
CFTPIAAHAI IKNDQLSLFA MLGKIDGRVI IRATEIGNSE EAKRIGFKVA SQLLEQGGDS 


LLRELKQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO91558.1.
RefSeqNP_821044.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83A37.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_2074.

Proteomic databases

PRIDEQ83A37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO91558; AAO91558; CBU_2074.
GeneID1209987.
KEGGcbu:CBU_2074.
PATRIC17932895. VBICoxBur82552_2064.

Phylogenomic databases

eggNOGCOG0181.
HOGENOMHOG000228587.
KOK01749.
OMAGIECRTD.
OrthoDBEOG6HB9Z6.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-2040-MONOMER.
UniPathwayUPA00251; UER00319.

Family and domain databases

Gene3D3.30.160.40. 1 hit.
HAMAPMF_00260. Porphobil_deam.
InterProIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERPTHR11557. PTHR11557. 1 hit.
PfamPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSPR00151. PORPHBDMNASE.
SUPFAMSSF54782. SSF54782. 1 hit.
TIGRFAMsTIGR00212. hemC. 1 hit.
PROSITEPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM3_COXBU
AccessionPrimary (citable) accession number: Q83A37
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names