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Q83A36

- AROD_COXBU

UniProt

Q83A36 - AROD_COXBU

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Protein
3-dehydroquinate dehydratase
Gene
aroD, CBU_2075
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641Substrate By similarity
Active sitei118 – 1181Proton donor/acceptor By similarity
Active sitei145 – 1451Schiff-base intermediate with substrate By similarity
Binding sitei185 – 1851Substrate By similarity
Binding sitei205 – 2051Substrate By similarity
Binding sitei209 – 2091Substrate By similarity

GO - Molecular functioni

  1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-2041-MONOMER.
UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydratase (EC:4.2.1.10)
Short name:
3-dehydroquinase
Alternative name(s):
Type I DHQase
Gene namesi
Name:aroD
Ordered Locus Names:CBU_2075
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2332333-dehydroquinate dehydrataseUniRule annotation
PRO_0000325521Add
BLAST

Proteomic databases

PRIDEiQ83A36.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_2075.

Structurei

3D structure databases

ProteinModelPortaliQ83A36.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 363Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0710.
HOGENOMiHOG000033727.
KOiK03785.
OMAiHYIDVEA.
OrthoDBiEOG6P33BK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00214. AroD.
InterProiIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamiPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01093. aroD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83A36-1 [UniParc]FASTAAdd to Basket

« Hide

MLNTPRICVV VIGKTLEEFL SQLEAAQTAV DFVELRIDYL EQINPNWVRI    50
IKNHTHKKAI LCCRARADGG KFLGTPEAQQ EILQAGNDLG FDYLDIDLPV 100
ANKISIHEKK AKIIISYHNF LHTPPITELN FLLENMRLFN PDVFKFATKS 150
EQYEDVKTLF KLLINKKNNE NMIVLGMGEQ GKIIRLLSPL LGGYLTFSSI 200
NGAISAPGQI DFKTMQDFYQ RFYKISSPLK GED 233
Length:233
Mass (Da):26,508
Last modified:June 1, 2003 - v1
Checksum:iC80AF9E997D8B2EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91559.1.
RefSeqiNP_821045.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91559; AAO91559; CBU_2075.
GeneIDi1209988.
KEGGicbu:CBU_2075.
PATRICi17932897. VBICoxBur82552_2065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91559.1 .
RefSeqi NP_821045.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83A36.
ModBasei Search...

Protein-protein interaction databases

STRINGi 227377.CBU_2075.

Proteomic databases

PRIDEi Q83A36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91559 ; AAO91559 ; CBU_2075 .
GeneIDi 1209988.
KEGGi cbu:CBU_2075.
PATRICi 17932897. VBICoxBur82552_2065.

Phylogenomic databases

eggNOGi COG0710.
HOGENOMi HOG000033727.
KOi K03785.
OMAi HYIDVEA.
OrthoDBi EOG6P33BK.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00086 .
BioCyci CBUR227377:GJ7S-2041-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00214. AroD.
InterProi IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view ]
Pfami PF01487. DHquinase_I. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01093. aroD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiAROD_COXBU
AccessioniPrimary (citable) accession number: Q83A36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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