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Protein

3-dehydroquinate dehydratase

Gene

aroD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 6413-dehydroquinateUniRule annotation
Active sitei118 – 1181Proton donor/acceptorUniRule annotation
Active sitei145 – 1451Schiff-base intermediate with substrateUniRule annotation
Binding sitei185 – 18513-dehydroquinateUniRule annotation
Binding sitei205 – 20513-dehydroquinateUniRule annotation
Binding sitei209 – 20913-dehydroquinateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-2041-MONOMER.
UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type I DHQaseUniRule annotation
Type I dehydroquinaseUniRule annotation
Short name:
DHQ1UniRule annotation
Gene namesi
Name:aroDUniRule annotation
Ordered Locus Names:CBU_2075
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2332333-dehydroquinate dehydratasePRO_0000325521Add
BLAST

Proteomic databases

PRIDEiQ83A36.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_2075.

Structurei

3D structure databases

ProteinModelPortaliQ83A36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 3633-dehydroquinate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type-I 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0710.
HOGENOMiHOG000033727.
KOiK03785.
OMAiTYASIES.
OrthoDBiEOG6P33BK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00214. AroD.
InterProiIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamiPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01093. aroD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83A36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNTPRICVV VIGKTLEEFL SQLEAAQTAV DFVELRIDYL EQINPNWVRI
60 70 80 90 100
IKNHTHKKAI LCCRARADGG KFLGTPEAQQ EILQAGNDLG FDYLDIDLPV
110 120 130 140 150
ANKISIHEKK AKIIISYHNF LHTPPITELN FLLENMRLFN PDVFKFATKS
160 170 180 190 200
EQYEDVKTLF KLLINKKNNE NMIVLGMGEQ GKIIRLLSPL LGGYLTFSSI
210 220 230
NGAISAPGQI DFKTMQDFYQ RFYKISSPLK GED
Length:233
Mass (Da):26,508
Last modified:June 1, 2003 - v1
Checksum:iC80AF9E997D8B2EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91559.1.
RefSeqiNP_821045.1. NC_002971.3.
WP_005772174.1. NZ_CCNR01000066.1.

Genome annotation databases

EnsemblBacteriaiAAO91559; AAO91559; CBU_2075.
GeneIDi1209988.
KEGGicbu:CBU_2075.
PATRICi17932897. VBICoxBur82552_2065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91559.1.
RefSeqiNP_821045.1. NC_002971.3.
WP_005772174.1. NZ_CCNR01000066.1.

3D structure databases

ProteinModelPortaliQ83A36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_2075.

Proteomic databases

PRIDEiQ83A36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO91559; AAO91559; CBU_2075.
GeneIDi1209988.
KEGGicbu:CBU_2075.
PATRICi17932897. VBICoxBur82552_2065.

Phylogenomic databases

eggNOGiCOG0710.
HOGENOMiHOG000033727.
KOiK03785.
OMAiTYASIES.
OrthoDBiEOG6P33BK.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.
BioCyciCBUR227377:GJ7S-2041-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00214. AroD.
InterProiIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamiPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01093. aroD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiAROD_COXBU
AccessioniPrimary (citable) accession number: Q83A36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: May 27, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.