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Q83A36

- AROD_COXBU

UniProt

Q83A36 - AROD_COXBU

Protein

3-dehydroquinate dehydratase

Gene

aroD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641SubstrateUniRule annotation
    Active sitei118 – 1181Proton donor/acceptorUniRule annotation
    Active sitei145 – 1451Schiff-base intermediate with substrateUniRule annotation
    Binding sitei185 – 1851SubstrateUniRule annotation
    Binding sitei205 – 2051SubstrateUniRule annotation
    Binding sitei209 – 2091SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-2041-MONOMER.
    UniPathwayiUPA00053; UER00086.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
    Short name:
    3-dehydroquinaseUniRule annotation
    Alternative name(s):
    Type I DHQaseUniRule annotation
    Gene namesi
    Name:aroDUniRule annotation
    Ordered Locus Names:CBU_2075
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2332333-dehydroquinate dehydratasePRO_0000325521Add
    BLAST

    Proteomic databases

    PRIDEiQ83A36.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_2075.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83A36.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni34 – 363Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the type-I 3-dehydroquinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0710.
    HOGENOMiHOG000033727.
    KOiK03785.
    OMAiHYIDVEA.
    OrthoDBiEOG6P33BK.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00214. AroD.
    InterProiIPR013785. Aldolase_TIM.
    IPR001381. DHquinase_I.
    [Graphical view]
    PfamiPF01487. DHquinase_I. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01093. aroD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83A36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNTPRICVV VIGKTLEEFL SQLEAAQTAV DFVELRIDYL EQINPNWVRI    50
    IKNHTHKKAI LCCRARADGG KFLGTPEAQQ EILQAGNDLG FDYLDIDLPV 100
    ANKISIHEKK AKIIISYHNF LHTPPITELN FLLENMRLFN PDVFKFATKS 150
    EQYEDVKTLF KLLINKKNNE NMIVLGMGEQ GKIIRLLSPL LGGYLTFSSI 200
    NGAISAPGQI DFKTMQDFYQ RFYKISSPLK GED 233
    Length:233
    Mass (Da):26,508
    Last modified:June 1, 2003 - v1
    Checksum:iC80AF9E997D8B2EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91559.1.
    RefSeqiNP_821045.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91559; AAO91559; CBU_2075.
    GeneIDi1209988.
    KEGGicbu:CBU_2075.
    PATRICi17932897. VBICoxBur82552_2065.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91559.1 .
    RefSeqi NP_821045.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83A36.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_2075.

    Proteomic databases

    PRIDEi Q83A36.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91559 ; AAO91559 ; CBU_2075 .
    GeneIDi 1209988.
    KEGGi cbu:CBU_2075.
    PATRICi 17932897. VBICoxBur82552_2065.

    Phylogenomic databases

    eggNOGi COG0710.
    HOGENOMi HOG000033727.
    KOi K03785.
    OMAi HYIDVEA.
    OrthoDBi EOG6P33BK.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00086 .
    BioCyci CBUR227377:GJ7S-2041-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00214. AroD.
    InterProi IPR013785. Aldolase_TIM.
    IPR001381. DHquinase_I.
    [Graphical view ]
    Pfami PF01487. DHquinase_I. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01093. aroD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiAROD_COXBU
    AccessioniPrimary (citable) accession number: Q83A36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3