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Q83A36 (AROD_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase

Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type I DHQase
Gene names
Name:aroD
Ordered Locus Names:CBU_2075
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00214

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00214

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2332333-dehydroquinate dehydratase HAMAP-Rule MF_00214
PRO_0000325521

Regions

Region34 – 363Substrate binding By similarity

Sites

Active site1181Proton donor/acceptor By similarity
Active site1451Schiff-base intermediate with substrate By similarity
Binding site641Substrate By similarity
Binding site1851Substrate By similarity
Binding site2051Substrate By similarity
Binding site2091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83A36 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C80AF9E997D8B2EC

FASTA23326,508
        10         20         30         40         50         60 
MLNTPRICVV VIGKTLEEFL SQLEAAQTAV DFVELRIDYL EQINPNWVRI IKNHTHKKAI 

        70         80         90        100        110        120 
LCCRARADGG KFLGTPEAQQ EILQAGNDLG FDYLDIDLPV ANKISIHEKK AKIIISYHNF 

       130        140        150        160        170        180 
LHTPPITELN FLLENMRLFN PDVFKFATKS EQYEDVKTLF KLLINKKNNE NMIVLGMGEQ 

       190        200        210        220        230 
GKIIRLLSPL LGGYLTFSSI NGAISAPGQI DFKTMQDFYQ RFYKISSPLK GED 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO91559.1.
RefSeqNP_821045.1. NC_002971.3.

3D structure databases

HSSPHSSP built from PDB template 2GPT based on UniProtKB Q9SQT8.
ProteinModelPortalQ83A36.
ModBaseSearch...

Protein-protein interaction databases

STRING227377.CBU_2075.

Proteomic databases

PRIDEQ83A36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO91559; AAO91559; CBU_2075.
GeneID1209988.
KEGGcbu:CBU_2075.
PATRIC17932897. VBICoxBur82552_2065.

Phylogenomic databases

eggNOGCOG0710.
HOGENOMHOG000033727.
KOK03785.
OMAIFTVRRR.
ProtClustDBCLSK915225.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-2041-MONOMER.
UniPathwayUPA00053; UER00086.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00214. AroD.
InterProIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsTIGR01093. aroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_COXBU
AccessionPrimary (citable) accession number: Q83A36
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families