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Protein

3-dehydroquinate dehydratase

Gene

aroD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (CBU_0982)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei643-dehydroquinateUniRule annotation1
Active sitei118Proton donor/acceptorUniRule annotation1
Active sitei145Schiff-base intermediate with substrateUniRule annotation1
Binding sitei1853-dehydroquinateUniRule annotation1
Binding sitei2053-dehydroquinateUniRule annotation1
Binding sitei2093-dehydroquinateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandSchiff base

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-2039-MONOMER
UniPathwayiUPA00053; UER00086

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type I DHQaseUniRule annotation
Type I dehydroquinaseUniRule annotation
Short name:
DHQ1UniRule annotation
Gene namesi
Name:aroDUniRule annotation
Ordered Locus Names:CBU_2075
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003255211 – 2333-dehydroquinate dehydrataseAdd BLAST233

Proteomic databases

PRIDEiQ83A36

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_2075

Structurei

3D structure databases

ProteinModelPortaliQ83A36
SMRiQ83A36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 363-dehydroquinate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the type-I 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FF2 Bacteria
COG0710 LUCA
HOGENOMiHOG000033727
KOiK03785
OMAiATMAMGE

Family and domain databases

CDDicd00502 DHQase_I, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00214 AroD, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001381 DHquinase_I
PfamiView protein in Pfam
PF01487 DHquinase_I, 1 hit
TIGRFAMsiTIGR01093 aroD, 1 hit

Sequencei

Sequence statusi: Complete.

Q83A36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNTPRICVV VIGKTLEEFL SQLEAAQTAV DFVELRIDYL EQINPNWVRI
60 70 80 90 100
IKNHTHKKAI LCCRARADGG KFLGTPEAQQ EILQAGNDLG FDYLDIDLPV
110 120 130 140 150
ANKISIHEKK AKIIISYHNF LHTPPITELN FLLENMRLFN PDVFKFATKS
160 170 180 190 200
EQYEDVKTLF KLLINKKNNE NMIVLGMGEQ GKIIRLLSPL LGGYLTFSSI
210 220 230
NGAISAPGQI DFKTMQDFYQ RFYKISSPLK GED
Length:233
Mass (Da):26,508
Last modified:June 1, 2003 - v1
Checksum:iC80AF9E997D8B2EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO91559.1
RefSeqiNP_821045.1, NC_002971.3
WP_005772174.1, NZ_LM994641.1

Genome annotation databases

EnsemblBacteriaiAAO91559; AAO91559; CBU_2075
GeneIDi1209988
31484751
KEGGicbu:CBU_2075
PATRICifig|227377.7.peg.2065

Similar proteinsi

Entry informationi

Entry nameiAROD_COXBU
AccessioniPrimary (citable) accession number: Q83A36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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