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Q83A36 (AROD_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase

Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type I DHQase
Gene names
Name:aroD
Ordered Locus Names:CBU_2075
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00214

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00214

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00214

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2332333-dehydroquinate dehydratase HAMAP-Rule MF_00214
PRO_0000325521

Regions

Region34 – 363Substrate binding By similarity

Sites

Active site1181Proton donor/acceptor By similarity
Active site1451Schiff-base intermediate with substrate By similarity
Binding site641Substrate By similarity
Binding site1851Substrate By similarity
Binding site2051Substrate By similarity
Binding site2091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83A36 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C80AF9E997D8B2EC

FASTA23326,508
        10         20         30         40         50         60 
MLNTPRICVV VIGKTLEEFL SQLEAAQTAV DFVELRIDYL EQINPNWVRI IKNHTHKKAI 

        70         80         90        100        110        120 
LCCRARADGG KFLGTPEAQQ EILQAGNDLG FDYLDIDLPV ANKISIHEKK AKIIISYHNF 

       130        140        150        160        170        180 
LHTPPITELN FLLENMRLFN PDVFKFATKS EQYEDVKTLF KLLINKKNNE NMIVLGMGEQ 

       190        200        210        220        230 
GKIIRLLSPL LGGYLTFSSI NGAISAPGQI DFKTMQDFYQ RFYKISSPLK GED 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO91559.1.
RefSeqNP_821045.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83A36.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_2075.

Proteomic databases

PRIDEQ83A36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO91559; AAO91559; CBU_2075.
GeneID1209988.
KEGGcbu:CBU_2075.
PATRIC17932897. VBICoxBur82552_2065.

Phylogenomic databases

eggNOGCOG0710.
HOGENOMHOG000033727.
KOK03785.
OMAHYIDVEA.
OrthoDBEOG6P33BK.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-2041-MONOMER.
UniPathwayUPA00053; UER00086.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00214. AroD.
InterProIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsTIGR01093. aroD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROD_COXBU
AccessionPrimary (citable) accession number: Q83A36
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names