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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:CBU_2095
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001131241 – 310Aspartate carbamoyltransferaseAdd BLAST310

Proteomic databases

PRIDEiQ83A16.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_2095.

Structurei

3D structure databases

ProteinModelPortaliQ83A16.
SMRiQ83A16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiWCDVANM.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR036901. Asp/Orn_carbamoylTrfase_sf.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
PANTHERiPTHR11405:SF16. PTHR11405:SF16. 1 hit.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83A16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELPLHLLN MRSLTRDHIE KLIQRANYFL TQGMEKNSVF ETLKGHVVAN
60 70 80 90 100
LFFEPSTRTR NSFEIAAKRL GAMVLNPNLK ISAISKGETL FDTIKTLEAM
110 120 130 140 150
GVYFFIVRHS ENETPEQIAK QLSSGVVINA GDGNHQHPSQ ALIDLMTIKQ
160 170 180 190 200
HKPHWNKLCV TIIGDIRHSR VANSLMDGLV TMGVPEIRLV GPSSLLPDKV
210 220 230 240 250
GNDSIKKFTE LKPSLLNSDV IVTLRLQKER HDNSVDIDAF RGSFRLTPEK
260 270 280 290 300
LYSAKPDAIV MHPGPVNREV EINSDVADNQ QSVILQQVRN GVAMRMAVLE
310
LFLLRDFRFF
Length:310
Mass (Da):34,944
Last modified:June 1, 2003 - v1
Checksum:i1900658F558E5A5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91579.1.
RefSeqiNP_821065.1. NC_002971.3.
WP_010958650.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaiAAO91579; AAO91579; CBU_2095.
GeneIDi1210008.
31484771.
KEGGicbu:CBU_2095.
PATRICifig|227377.7.peg.2086.

Similar proteinsi

Entry informationi

Entry nameiPYRB_COXBU
AccessioniPrimary (citable) accession number: Q83A16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families