Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q839Z9 (CPDA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:CBUA0032
Encoded onPlasmid pQpH1
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2482483',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413366

Regions

Nucleotide binding82 – 832cAMP By similarity

Sites

Metal binding131Metal cation 1 By similarity
Metal binding151Metal cation 1 By similarity
Metal binding521Metal cation 1 By similarity
Metal binding521Metal cation 2 By similarity
Metal binding821Metal cation 2 By similarity
Metal binding1521Metal cation 2 By similarity
Metal binding1911Metal cation 2 By similarity
Metal binding1931Metal cation 1 By similarity
Binding site151cAMP By similarity
Binding site521cAMP By similarity
Binding site1931cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q839Z9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: D37DD91AAE70BEB6

FASTA24829,002
        10         20         30         40         50         60 
MEDNCIKIAQ VSDLHLTSEN CETSRGRYSN AMNVFSAISL SGQHDMIFIT GDISDDYTEN 

        70         80         90        100        110        120 
SYKQLLEMLK KLTCRVFVIP GNHDDVNLMN KIIPEKYLFS PETVTSFNTF DFLFVNTVVN 

       130        140        150        160        170        180 
GEIHGLLTDQ DLSLFQNHLE NSGNKKKCII MHHNPIPLNR KIYDKYMLLN YQDFLRIICL 

       190        200        210        220        230        240 
YDNVKLVIFG HVHNDYTISY RQTLFSSAPA TCYQIKKFES DIIIEEKYGY KNYFLFEEFI 


ETNCIWIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016829 Genomic DNA. Translation: AAO91608.1.
RefSeqNP_819048.1. NC_004704.1.

3D structure databases

ProteinModelPortalQ839Z9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBUA0032.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO91608; AAO91608; CBUA0032.
GeneID1207862.
KEGGcbu:CBUA0032.
PATRIC17933012. VBICoxBur82552_2122.

Phylogenomic databases

HOGENOMHOG000027356.
OMAWQIIMLD.
OrthoDBEOG6QG8GQ.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-2089-MONOMER.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPDA_COXBU
AccessionPrimary (citable) accession number: Q839Z9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names