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Q839Z9

- CPDA_COXBU

UniProt

Q839Z9 - CPDA_COXBU

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi13 – 131Metal cation 1UniRule annotation
    Metal bindingi15 – 151Metal cation 1UniRule annotation
    Binding sitei15 – 151cAMPUniRule annotation
    Metal bindingi52 – 521Metal cation 1UniRule annotation
    Metal bindingi52 – 521Metal cation 2UniRule annotation
    Binding sitei52 – 521cAMPUniRule annotation
    Metal bindingi82 – 821Metal cation 2UniRule annotation
    Metal bindingi152 – 1521Metal cation 2UniRule annotation
    Metal bindingi191 – 1911Metal cation 2UniRule annotation
    Metal bindingi193 – 1931Metal cation 1UniRule annotation
    Binding sitei193 – 1931cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi82 – 832cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-2089-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:CBUA0032
    Encoded oniPlasmid pQpH10 Publication
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Plasmid pQpH1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2482483',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413366Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBUA0032.

    Structurei

    3D structure databases

    ProteinModelPortaliQ839Z9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000027356.
    OMAiWQIIMLD.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q839Z9-1 [UniParc]FASTAAdd to Basket

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    MEDNCIKIAQ VSDLHLTSEN CETSRGRYSN AMNVFSAISL SGQHDMIFIT    50
    GDISDDYTEN SYKQLLEMLK KLTCRVFVIP GNHDDVNLMN KIIPEKYLFS 100
    PETVTSFNTF DFLFVNTVVN GEIHGLLTDQ DLSLFQNHLE NSGNKKKCII 150
    MHHNPIPLNR KIYDKYMLLN YQDFLRIICL YDNVKLVIFG HVHNDYTISY 200
    RQTLFSSAPA TCYQIKKFES DIIIEEKYGY KNYFLFEEFI ETNCIWIK 248
    Length:248
    Mass (Da):29,002
    Last modified:June 1, 2003 - v1
    Checksum:iD37DD91AAE70BEB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016829 Genomic DNA. Translation: AAO91608.1.
    RefSeqiNP_819048.1. NC_004704.1.
    WP_011109651.1. NC_004704.1.

    Genome annotation databases

    EnsemblBacteriaiAAO91608; AAO91608; CBUA0032.
    GeneIDi1207862.
    KEGGicbu:CBUA0032.
    PATRICi17933012. VBICoxBur82552_2122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016829 Genomic DNA. Translation: AAO91608.1 .
    RefSeqi NP_819048.1. NC_004704.1.
    WP_011109651.1. NC_004704.1.

    3D structure databases

    ProteinModelPortali Q839Z9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBUA0032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91608 ; AAO91608 ; CBUA0032 .
    GeneIDi 1207862.
    KEGGi cbu:CBUA0032.
    PATRICi 17933012. VBICoxBur82552_2122.

    Phylogenomic databases

    HOGENOMi HOG000027356.
    OMAi WQIIMLD.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-2089-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiCPDA_COXBU
    AccessioniPrimary (citable) accession number: Q839Z9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3