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Q839Z9

- CPDA_COXBU

UniProt

Q839Z9 - CPDA_COXBU

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, CBUA0032
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Metal cation 1 By similarity
Metal bindingi15 – 151Metal cation 1 By similarity
Binding sitei15 – 151cAMP By similarity
Metal bindingi52 – 521Metal cation 1 By similarity
Metal bindingi52 – 521Metal cation 2 By similarity
Binding sitei52 – 521cAMP By similarity
Metal bindingi82 – 821Metal cation 2 By similarity
Metal bindingi152 – 1521Metal cation 2 By similarity
Metal bindingi191 – 1911Metal cation 2 By similarity
Metal bindingi193 – 1931Metal cation 1 By similarity
Binding sitei193 – 1931cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 832cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-2089-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:CBUA0032
Encoded oniPlasmid pQpH10 Publication
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Plasmid pQpH1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2482483',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000413366Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBUA0032.

Structurei

3D structure databases

ProteinModelPortaliQ839Z9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000027356.
OMAiWQIIMLD.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q839Z9-1 [UniParc]FASTAAdd to Basket

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MEDNCIKIAQ VSDLHLTSEN CETSRGRYSN AMNVFSAISL SGQHDMIFIT    50
GDISDDYTEN SYKQLLEMLK KLTCRVFVIP GNHDDVNLMN KIIPEKYLFS 100
PETVTSFNTF DFLFVNTVVN GEIHGLLTDQ DLSLFQNHLE NSGNKKKCII 150
MHHNPIPLNR KIYDKYMLLN YQDFLRIICL YDNVKLVIFG HVHNDYTISY 200
RQTLFSSAPA TCYQIKKFES DIIIEEKYGY KNYFLFEEFI ETNCIWIK 248
Length:248
Mass (Da):29,002
Last modified:June 1, 2003 - v1
Checksum:iD37DD91AAE70BEB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016829 Genomic DNA. Translation: AAO91608.1.
RefSeqiNP_819048.1. NC_004704.1.
WP_011109651.1. NC_004704.1.

Genome annotation databases

EnsemblBacteriaiAAO91608; AAO91608; CBUA0032.
GeneIDi1207862.
KEGGicbu:CBUA0032.
PATRICi17933012. VBICoxBur82552_2122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016829 Genomic DNA. Translation: AAO91608.1 .
RefSeqi NP_819048.1. NC_004704.1.
WP_011109651.1. NC_004704.1.

3D structure databases

ProteinModelPortali Q839Z9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBUA0032.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91608 ; AAO91608 ; CBUA0032 .
GeneIDi 1207862.
KEGGi cbu:CBUA0032.
PATRICi 17933012. VBICoxBur82552_2122.

Phylogenomic databases

HOGENOMi HOG000027356.
OMAi WQIIMLD.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-2089-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiCPDA_COXBU
AccessioniPrimary (citable) accession number: Q839Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi