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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13Metal cation 1UniRule annotation1
Metal bindingi15Metal cation 1UniRule annotation1
Binding sitei15cAMPUniRule annotation1
Metal bindingi52Metal cation 1UniRule annotation1
Metal bindingi52Metal cation 2UniRule annotation1
Binding sitei52cAMPUniRule annotation1
Metal bindingi82Metal cation 2UniRule annotation1
Metal bindingi152Metal cation 2UniRule annotation1
Metal bindingi191Metal cation 2UniRule annotation1
Metal bindingi193Metal cation 1UniRule annotation1
Binding sitei193cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 83cAMPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:CBUA0032
Encoded oniPlasmid pQpH10 Publication
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Plasmid pQpH1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133661 – 2483',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST248

Structurei

3D structure databases

ProteinModelPortaliQ839Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000027356.
OMAiESYHSFV.

Family and domain databases

CDDicd07402. MPP_GpdQ. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q839Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDNCIKIAQ VSDLHLTSEN CETSRGRYSN AMNVFSAISL SGQHDMIFIT
60 70 80 90 100
GDISDDYTEN SYKQLLEMLK KLTCRVFVIP GNHDDVNLMN KIIPEKYLFS
110 120 130 140 150
PETVTSFNTF DFLFVNTVVN GEIHGLLTDQ DLSLFQNHLE NSGNKKKCII
160 170 180 190 200
MHHNPIPLNR KIYDKYMLLN YQDFLRIICL YDNVKLVIFG HVHNDYTISY
210 220 230 240
RQTLFSSAPA TCYQIKKFES DIIIEEKYGY KNYFLFEEFI ETNCIWIK
Length:248
Mass (Da):29,002
Last modified:June 1, 2003 - v1
Checksum:iD37DD91AAE70BEB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016829 Genomic DNA. Translation: AAO91608.1.
RefSeqiNP_819048.1. NC_004704.1.
WP_011109651.1. NC_004704.1.

Genome annotation databases

EnsemblBacteriaiAAO91608; AAO91608; CBUA0032.
GeneIDi1207862.
KEGGicbu:CBUA0032.
PATRICi17933012. VBICoxBur82552_2122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016829 Genomic DNA. Translation: AAO91608.1.
RefSeqiNP_819048.1. NC_004704.1.
WP_011109651.1. NC_004704.1.

3D structure databases

ProteinModelPortaliQ839Z9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO91608; AAO91608; CBUA0032.
GeneIDi1207862.
KEGGicbu:CBUA0032.
PATRICi17933012. VBICoxBur82552_2122.

Phylogenomic databases

HOGENOMiHOG000027356.
OMAiESYHSFV.

Family and domain databases

CDDicd07402. MPP_GpdQ. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_COXBU
AccessioniPrimary (citable) accession number: Q839Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.