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Q839W2

- PROB_ENTFA

UniProt

Q839W2 - PROB_ENTFA

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Protein

Glutamate 5-kinase

Gene
proB, EF_0038
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141ATP By similarity
Binding sitei54 – 541Substrate By similarity
Binding sitei141 – 1411Substrate By similarity
Binding sitei157 – 1571Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 1782ATP By similarity
Nucleotide bindingi219 – 2257ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-35-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase
Short name:
GK
Gene namesi
Name:proB
Ordered Locus Names:EF_0038
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Glutamate 5-kinaseUniRule annotationPRO_0000109672Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226185.EF0038.

Structurei

3D structure databases

ProteinModelPortaliQ839W2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0263.
KOiK00931.
OMAiADDFDSR.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q839W2-1 [UniParc]FASTAAdd to Basket

« Hide

MRNKLQQAKR IVIKVGTSSL IYPNGNINLK AIDQLAFTLS DLSNQGKEII    50
LVSSGAIGVG LNKLNLSVRP TTIPEQQAVA AVGQAELMNI YNQRFSTYSQ 100
QMAQVLLTRD VIEYPESRNN VTNTFEQLLK MNIIPIVNEN DTVAIEELDH 150
LTKFGDNDQL SAIVCQIVQA DLLVMLSDID GFFSDNPTVN KEATLFSEIN 200
EINEDLFQLA GGKGSRFGTG GMSSKLKAAE RVLANQQAMI LANGKQPKII 250
FEILEGKDIG TLFIKGGHES D 271
Length:271
Mass (Da):29,700
Last modified:June 1, 2003 - v1
Checksum:iA69A7986D0EB54C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO79920.1.
RefSeqiNP_813848.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO79920; AAO79920; EF_0038.
GeneIDi1198946.
KEGGiefa:EF0038.
PATRICi21850507. VBIEntFae7065_0035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO79920.1 .
RefSeqi NP_813848.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q839W2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF0038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO79920 ; AAO79920 ; EF_0038 .
GeneIDi 1198946.
KEGGi efa:EF0038.
PATRICi 21850507. VBIEntFae7065_0035.

Phylogenomic databases

eggNOGi COG0263.
KOi K00931.
OMAi ADDFDSR.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci EFAE226185:GHI1-35-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiPROB_ENTFA
AccessioniPrimary (citable) accession number: Q839W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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