Reviewed, UniProtKB/Swiss-Prot Q839J4 (ADD_ENTFA)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	EF_0171

Organism

Enterococcus faecalis (Streptococcus faecalis) [Complete proteome] [HAMAP]

Taxonomic identifier

1351 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Enterococcaceae › Enterococcus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Adenosine deaminase HAMAP MF_00540		PRO_0000194370
Sites
	Active site	199	1	Potential
	Active site	246	1	Potential
	Active site	279	1	Potential
	Active site	280	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q839J4-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: DA72368463DA25F3	FASTA	337	37,362
	10 20 30 40 50 60 MEESRVRQLP KIELHCHLDG SIRPTTLRTI AEKQNIPLPQ DEQALKELVV APEKCTDLND 70 80 90 100 110 120 YLTRFDFVLT CLQTAEALQA AAYDVISQAA EDGVAYIEVR FAPSQHTEKG LRLPEIVTAV 130 140 150 160 170 180 LTGLKQGEED FGVKSNALLC GMRHDQQQAI EKIVHLAHDF RETGVVGFDL AGNEVDFPPY 190 200 210 220 230 240 TFEDVLALAN QLSIPLTLHA GECGCGKNVA DAVTLGATRI GHGIALKDTP EYLALLKEKK 250 260 270 280 290 300 VLLEMCPTSN FQTGTVKTLA EYPFQQFIEA GLAVCINTDN RTVSDTTLTK EFMKLATWYQ 310 320 330 LSYDEMKQLT KNALAGAFLS PDEKKLLNQK IDQAYLF

References

[1]

"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis." Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A. , Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M. Science 299:2071-2074(2003) [PubMed: 12663927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: V583 / ATCC 700802.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016830 Genomic DNA. Translation: AAO80045.1.
RefSeq	NP_813973.1.
3D structure databases
HSSP	HSSP built from PDB template 1KRM based on UniProtKB P56658.
ModBase	Search...
Genome annotation databases
GeneID	1199071.
GenomeReviews	Gene locus EF_0171 in contig AE016830_GR.
KEGG	efa:EF0171.
NMPDR	fig|226185.1.peg.160.
TIGR	EF_0171.
Phylogenomic databases
HOGENOM	Q839J4.
OMA	FLKKLDW.
Enzyme and pathway databases
BioCyc	EFAE226185:EF_0171-MON.
BRENDA	3.5.4.4. 704.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_ENTFA

Accession

Primary (citable) accession number: Q839J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)