Q839J4 (ADD_ENTFA) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 51.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenosine deaminase EC=3.5.4.4 Alternative name(s): Adenosine aminohydrolase | ||||
| Gene names |
| ||||
| Organism | Enterococcus faecalis (Streptococcus faecalis) | ||||
| Taxonomic identifier | 1351 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Enterococcaceae › Enterococcus |
Protein attributes
| Sequence length | 337 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Adenosine + H2O = inosine + NH3. HAMAP MF_00540 |
| Cofactor | Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540 |
| Sequence similarities | Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | adenosine deaminase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 337 | 337 | Adenosine deaminase HAMAP MF_00540 | PRO_0000194370 | |||||
Sites | |||||||||
| Active site | 202 | 1 | Proton donor By similarity | ||||||
| Metal binding | 15 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 17 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 199 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 279 | 1 | Zinc; catalytic By similarity | ||||||
| Binding site | 17 | 1 | Substrate By similarity | ||||||
| Binding site | 19 | 1 | Substrate By similarity | ||||||
| Binding site | 172 | 1 | Substrate; via amide nitrogen and carbonyl oxygen By similarity | ||||||
| Site | 222 | 1 | Important for catalytic activity By similarity | ||||||
Sequences
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References
| [1] | "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis." Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A. Fraser C.M.Science 299:2071-2074(2003) [PubMed: 12663927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700802 / V583. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016830 Genomic DNA. Translation: AAO80045.1. |
| RefSeq | NP_813973.1. NC_004668.1. |
3D structure databases | |
| ProteinModelPortal | Q839J4. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1199071. |
| GenomeReviews | Gene locus EF_0171 in contig AE016830_GR. |
| KEGG | efa:EF0171. |
| NMPDR | fig|226185.1.peg.160. |
| PATRIC | 21850753. VBIEntFae7065_0158. |
| TIGR | EF_0171. |
Phylogenomic databases | |
| HOGENOM | HBG630382. |
| OMA | PYYMAMN. |
| ProtClustDB | PRK09358. |
Enzyme and pathway databases | |
| BioCyc | EFAE226185:EF_0171-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00540. A_deaminase. [Tree] |
| InterPro | IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view] |
| KO | K01488. |
| PANTHER | PTHR11409:SF21. PTHR11409:SF21. 1 hit. |
| Pfam | PF00962. A_deaminase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01430. Aden_deam. 1 hit. |
| PROSITE | PS00485. A_DEAMINASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADD_ENTFA | ||||||||
| Accession | Primary (citable) accession number: Q839J4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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