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Q83927

- RDRP_OCSVU

UniProt

Q83927 - RDRP_OCSVU

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Oat chlorotic stunt virus (isolate United Kingdom) (OCSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p84
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiOat chlorotic stunt virus (isolate United Kingdom) (OCSV)
    Taxonomic identifieri652110 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeAvenavirus
    Virus hostiAvena sativa (Oat) [TaxID: 4498]
    ProteomesiUP000000573: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 752752RNA-directed RNA polymerasePRO_0000399490Add
    BLAST
    Chaini1 – 212212Protein p23PRO_0000399491Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ83927.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini442 – 561120RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q83927-1 [UniParc]FASTAAdd to Basket

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    MSWPSLSGVP NGSSSVSTWL SVTHPRRSLP KELLTAFDTC NVAPEALLVL    50
    RSTSLMILEE TCVVVGAAEM PTAEDNSGRE LFIGSNGDPM ERKTRTAHHA 100
    IKKTVRIKKG HRTTFAMTVA NGAYVKFGAR PLTEANVLVV RKWIVKLIAD 150
    EYKDLRVCDQ ALVIDRATFL SFIPTMAWNN YKFIFHGKNA VTDRVAGENL 200
    FSRIAQWANP GKXGCPVVVT GQGCVISRAP DCAQLRVKRL LGVTKNRTCM 250
    RVSGVSPNIQ IIPFNNDITT LERAIKERVF FVKNLDKGSP TKFVSPPRPA 300
    PGVFAQRLSN TLGLLVPFLP STAPMSHQQF VDSTPSRKRK VYQQALEDIS 350
    CHGLNLETDS KVKVFVKYEK TDHTSKADPV PRVISPRDPK YNLALGRYLR 400
    PMEERIFKAL GKLFGHRTVM KGMDTDVTAR VIQEKWNMFN KPVAIGLDAS 450
    RFDQHVSLEA LEFEHSVYLK CVRRMVDKRK LGNILRHQLL NKCYGNTPDG 500
    AVSYTIEGTR MSGDMNTSLG NCVLMCMMIH AYGLHKSVNI QLANNGDDCV 550
    VFLEQSDLAT FSEGLFEWFL EMGFNMAIEE PSYELEHIEF CQCRPVFDGV 600
    KYTMCRNPRT AIAKDSVYLK HVDQFVTYSS WLNAVGTGGL ALAGGLPIFD 650
    AFYTCYKRNS NSHWFSGRKG RLKTLSSVDD SLPWFMRELG LKGKRSSAEP 700
    LPASRASFYL AWGVTPCEQL ELEKYYKSFK LDTSTLLEEH LWQPRGVFPD 750
    ED 752
    Length:752
    Mass (Da):84,449
    Last modified:November 1, 1996 - v1
    Checksum:i798BB83729EC00C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83964 Genomic RNA. Translation: CAA58796.1.
    X83964 Genomic RNA. Translation: CAA58797.1.
    RefSeqiNP_619751.1. NC_003633.1.
    NP_619752.1. NC_003633.1.

    Genome annotation databases

    GeneIDi1732851.
    940248.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83964 Genomic RNA. Translation: CAA58796.1 .
    X83964 Genomic RNA. Translation: CAA58797.1 .
    RefSeqi NP_619751.1. NC_003633.1.
    NP_619752.1. NC_003633.1.

    3D structure databases

    ProteinModelPortali Q83927.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1732851.
    940248.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence and proposed genome organization of oat chlorotic stunt virus, a new soil-borne virus of cereals."
      Boonham N., Henry C.M., Wood K.R.
      J. Gen. Virol. 76:2025-2034(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_OCSVU
    AccessioniPrimary (citable) accession number: Q83927
    Secondary accession number(s): Q83926
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 213.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3