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Q83927

- RDRP_OCSVU

UniProt

Q83927 - RDRP_OCSVU

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Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Oat chlorotic stunt virus (isolate United Kingdom) (OCSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p84
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiOat chlorotic stunt virus (isolate United Kingdom) (OCSV)
Taxonomic identifieri652110 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeAvenavirus
Virus hostiAvena sativa (Oat) [TaxID: 4498]
ProteomesiUP000000573: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752RNA-directed RNA polymerasePRO_0000399490Add
BLAST
Chaini1 – 212212Protein p23PRO_0000399491Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ83927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini442 – 561120RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83927-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWPSLSGVP NGSSSVSTWL SVTHPRRSLP KELLTAFDTC NVAPEALLVL
60 70 80 90 100
RSTSLMILEE TCVVVGAAEM PTAEDNSGRE LFIGSNGDPM ERKTRTAHHA
110 120 130 140 150
IKKTVRIKKG HRTTFAMTVA NGAYVKFGAR PLTEANVLVV RKWIVKLIAD
160 170 180 190 200
EYKDLRVCDQ ALVIDRATFL SFIPTMAWNN YKFIFHGKNA VTDRVAGENL
210 220 230 240 250
FSRIAQWANP GKXGCPVVVT GQGCVISRAP DCAQLRVKRL LGVTKNRTCM
260 270 280 290 300
RVSGVSPNIQ IIPFNNDITT LERAIKERVF FVKNLDKGSP TKFVSPPRPA
310 320 330 340 350
PGVFAQRLSN TLGLLVPFLP STAPMSHQQF VDSTPSRKRK VYQQALEDIS
360 370 380 390 400
CHGLNLETDS KVKVFVKYEK TDHTSKADPV PRVISPRDPK YNLALGRYLR
410 420 430 440 450
PMEERIFKAL GKLFGHRTVM KGMDTDVTAR VIQEKWNMFN KPVAIGLDAS
460 470 480 490 500
RFDQHVSLEA LEFEHSVYLK CVRRMVDKRK LGNILRHQLL NKCYGNTPDG
510 520 530 540 550
AVSYTIEGTR MSGDMNTSLG NCVLMCMMIH AYGLHKSVNI QLANNGDDCV
560 570 580 590 600
VFLEQSDLAT FSEGLFEWFL EMGFNMAIEE PSYELEHIEF CQCRPVFDGV
610 620 630 640 650
KYTMCRNPRT AIAKDSVYLK HVDQFVTYSS WLNAVGTGGL ALAGGLPIFD
660 670 680 690 700
AFYTCYKRNS NSHWFSGRKG RLKTLSSVDD SLPWFMRELG LKGKRSSAEP
710 720 730 740 750
LPASRASFYL AWGVTPCEQL ELEKYYKSFK LDTSTLLEEH LWQPRGVFPD

ED
Length:752
Mass (Da):84,449
Last modified:November 1, 1996 - v1
Checksum:i798BB83729EC00C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83964 Genomic RNA. Translation: CAA58796.1.
X83964 Genomic RNA. Translation: CAA58797.1.
RefSeqiNP_619751.1. NC_003633.1.
NP_619752.1. NC_003633.1.

Genome annotation databases

GeneIDi1732851.
940248.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83964 Genomic RNA. Translation: CAA58796.1 .
X83964 Genomic RNA. Translation: CAA58797.1 .
RefSeqi NP_619751.1. NC_003633.1.
NP_619752.1. NC_003633.1.

3D structure databases

ProteinModelPortali Q83927.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1732851.
940248.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The nucleotide sequence and proposed genome organization of oat chlorotic stunt virus, a new soil-borne virus of cereals."
    Boonham N., Henry C.M., Wood K.R.
    J. Gen. Virol. 76:2025-2034(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_OCSVU
AccessioniPrimary (citable) accession number: Q83927
Secondary accession number(s): Q83926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 213.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3