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Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Oat chlorotic stunt virus (isolate United Kingdom) (OCSV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p84
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiOat chlorotic stunt virus (isolate United Kingdom) (OCSV)
Taxonomic identifieri652110 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTombusviridaeAvenavirus
Virus hostiAvena sativa (Oat) [TaxID: 4498]
Proteomesi
  • UP000000573 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003994901 – 752RNA-directed RNA polymeraseAdd BLAST752
ChainiPRO_00003994911 – 212Protein p23Add BLAST212

Structurei

3D structure databases

ProteinModelPortaliQ83927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini442 – 561RdRp catalyticPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWPSLSGVP NGSSSVSTWL SVTHPRRSLP KELLTAFDTC NVAPEALLVL
60 70 80 90 100
RSTSLMILEE TCVVVGAAEM PTAEDNSGRE LFIGSNGDPM ERKTRTAHHA
110 120 130 140 150
IKKTVRIKKG HRTTFAMTVA NGAYVKFGAR PLTEANVLVV RKWIVKLIAD
160 170 180 190 200
EYKDLRVCDQ ALVIDRATFL SFIPTMAWNN YKFIFHGKNA VTDRVAGENL
210 220 230 240 250
FSRIAQWANP GKXGCPVVVT GQGCVISRAP DCAQLRVKRL LGVTKNRTCM
260 270 280 290 300
RVSGVSPNIQ IIPFNNDITT LERAIKERVF FVKNLDKGSP TKFVSPPRPA
310 320 330 340 350
PGVFAQRLSN TLGLLVPFLP STAPMSHQQF VDSTPSRKRK VYQQALEDIS
360 370 380 390 400
CHGLNLETDS KVKVFVKYEK TDHTSKADPV PRVISPRDPK YNLALGRYLR
410 420 430 440 450
PMEERIFKAL GKLFGHRTVM KGMDTDVTAR VIQEKWNMFN KPVAIGLDAS
460 470 480 490 500
RFDQHVSLEA LEFEHSVYLK CVRRMVDKRK LGNILRHQLL NKCYGNTPDG
510 520 530 540 550
AVSYTIEGTR MSGDMNTSLG NCVLMCMMIH AYGLHKSVNI QLANNGDDCV
560 570 580 590 600
VFLEQSDLAT FSEGLFEWFL EMGFNMAIEE PSYELEHIEF CQCRPVFDGV
610 620 630 640 650
KYTMCRNPRT AIAKDSVYLK HVDQFVTYSS WLNAVGTGGL ALAGGLPIFD
660 670 680 690 700
AFYTCYKRNS NSHWFSGRKG RLKTLSSVDD SLPWFMRELG LKGKRSSAEP
710 720 730 740 750
LPASRASFYL AWGVTPCEQL ELEKYYKSFK LDTSTLLEEH LWQPRGVFPD

ED
Length:752
Mass (Da):84,449
Last modified:November 1, 1996 - v1
Checksum:i798BB83729EC00C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83964 Genomic RNA. Translation: CAA58796.1.
X83964 Genomic RNA. Translation: CAA58797.1.
RefSeqiNP_619751.1. NC_003633.1.
NP_619752.1. NC_003633.1.

Genome annotation databases

GeneIDi1732851.
940248.
KEGGivg:1732851.
vg:940248.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83964 Genomic RNA. Translation: CAA58796.1.
X83964 Genomic RNA. Translation: CAA58797.1.
RefSeqiNP_619751.1. NC_003633.1.
NP_619752.1. NC_003633.1.

3D structure databases

ProteinModelPortaliQ83927.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1732851.
940248.
KEGGivg:1732851.
vg:940248.

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRDRP_OCSVU
AccessioniPrimary (citable) accession number: Q83927
Secondary accession number(s): Q83926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 213.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.