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Protein

4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase 1

Gene

kduI1

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.By similarity

Catalytic activityi

5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: pectin degradation

This protein is involved in step 4 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase 2 (kduI2), 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase 1 (kduI1)
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi194ZincBy similarity1
Metal bindingi196ZincBy similarity1
Metal bindingi201ZincBy similarity1
Metal bindingi243ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00545; UER00826.

Names & Taxonomyi

Protein namesi
Recommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase 1 (EC:5.3.1.17)
Alternative name(s):
5-keto-4-deoxyuronate isomerase 1
DKI isomerase 1
Gene namesi
Name:kduI1
Synonyms:kduI-1
Ordered Locus Names:EF_0425
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002154881 – 2764-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase 1Add BLAST276

Interactioni

Protein-protein interaction databases

STRINGi226185.EF0425.

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 4Combined sources4
Helixi9 – 12Combined sources4
Helixi17 – 24Combined sources8
Beta strandi25 – 27Combined sources3
Beta strandi34 – 40Combined sources7
Turni41 – 44Combined sources4
Beta strandi45 – 50Combined sources6
Beta strandi53 – 55Combined sources3
Helixi63 – 65Combined sources3
Beta strandi67 – 69Combined sources3
Turni70 – 73Combined sources4
Beta strandi74 – 80Combined sources7
Beta strandi85 – 89Combined sources5
Beta strandi92 – 96Combined sources5
Beta strandi101 – 104Combined sources4
Beta strandi111 – 116Combined sources6
Beta strandi124 – 130Combined sources7
Beta strandi138 – 140Combined sources3
Turni142 – 144Combined sources3
Helixi153 – 155Combined sources3
Beta strandi159 – 166Combined sources8
Turni167 – 169Combined sources3
Beta strandi176 – 182Combined sources7
Beta strandi200 – 207Combined sources8
Beta strandi214 – 220Combined sources7
Beta strandi225 – 229Combined sources5
Beta strandi233 – 237Combined sources5
Beta strandi245 – 249Combined sources5
Beta strandi252 – 258Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWKX-ray2.95A/B/C/D/E/F1-276[»]
ProteinModelPortaliQ838L9.
SMRiQ838L9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ838L9.

Family & Domainsi

Sequence similaritiesi

Belongs to the KduI family.Curated

Phylogenomic databases

eggNOGiENOG4105D50. Bacteria.
COG3717. LUCA.
KOiK01815.
OMAiHELRMEA.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI. 1 hit.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q838L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRYTHSPA DIRHYSTEQL RDEFLVEKVF IPGAISLTYT HNDRMIFGGV
60 70 80 90 100
TPTTEELEII LDKELGVDYF LERRELGVIN IGGPGFIEID GAKETMKKQD
110 120 130 140 150
GYYIGKETKH VRFSSENPDN PAKFYISCVP AHHKYPNVKI SIDEITPMET
160 170 180 190 200
GDPLTLNQRK IYQYIHPNVC ESCQLQMGYT ILEPGSAWNT MPCHTHERRM
210 220 230 240 250
EAYVYFDMEE DTRIFHMMGK PDETKHLVMS NEQAAISPSW SIHSGVGTSN
260 270
YSFIWAMCGE NITYTDMDMV AMDQLK
Length:276
Mass (Da):31,745
Last modified:June 1, 2003 - v1
Checksum:i2E3EF367E13A24B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO80282.1.
RefSeqiNP_814211.1. NC_004668.1.
WP_011109446.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO80282; AAO80282; EF_0425.
GeneIDi1199341.
KEGGiefa:EF0425.
PATRICi21851283. VBIEntFae7065_0394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO80282.1.
RefSeqiNP_814211.1. NC_004668.1.
WP_011109446.1. NC_004668.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWKX-ray2.95A/B/C/D/E/F1-276[»]
ProteinModelPortaliQ838L9.
SMRiQ838L9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF0425.

Protocols and materials databases

DNASUi1199341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO80282; AAO80282; EF_0425.
GeneIDi1199341.
KEGGiefa:EF0425.
PATRICi21851283. VBIEntFae7065_0394.

Phylogenomic databases

eggNOGiENOG4105D50. Bacteria.
COG3717. LUCA.
KOiK01815.
OMAiHELRMEA.

Enzyme and pathway databases

UniPathwayiUPA00545; UER00826.

Miscellaneous databases

EvolutionaryTraceiQ838L9.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI. 1 hit.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKDUI1_ENTFA
AccessioniPrimary (citable) accession number: Q838L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.