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Q838I3

- DAPF_ENTFA

UniProt

Q838I3 - DAPF_ENTFA

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Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131SubstrateUniRule annotation
Binding sitei52 – 521SubstrateUniRule annotation
Binding sitei72 – 721SubstrateUniRule annotation
Active sitei81 – 811Proton donor/acceptorUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Sitei171 – 1711Important for catalytic activityUniRule annotation
Binding sitei205 – 2051SubstrateUniRule annotation
Sitei223 – 2231Important for catalytic activityUniRule annotation
Active sitei232 – 2321Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-467-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
Short name:
DAP epimeraseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
Ordered Locus Names:EF_0464
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Diaminopimelate epimerasePRO_1000011876Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi81 ↔ 232

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi226185.EF0464.

Structurei

3D structure databases

ProteinModelPortaliQ838I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 833Substrate bindingUniRule annotation
Regioni223 – 2242Substrate bindingUniRule annotation
Regioni233 – 2342Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0253.
KOiK01778.
OMAiKFNDITT.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q838I3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVMMQKVHG SENDFFLLDE TQFERSLTAE EIEQLRIQLC SRETGLLAGA
60 70 80 90 100
DGLLLVGEGT HGTSNARMRV INSDGSEASM CGNGLRTVAR YLAEKNQEKS
110 120 130 140 150
FTVETMFADL KVRQAPNLAE EVATYQVEIS PVSFEAVTIP MHLGVQTLID
160 170 180 190 200
EIVPALSNTI RFTAVAVPNP HLVAFVDHET LNGPEFERIA TYVNNENPYF
210 220 230 240 250
PEGINVSFVE ILGKNQLFVR TYERGVGFTS ACGTAMCASS LLYTLLKDGV
260 270 280 290 300
FYEEITVKNT GGMVKTVVHE TSDGSYWMEL IGNATITHLI EGSLTDLLNG
310 320
AFEKITITET NEQKHYQEFL QTLSQK
Length:326
Mass (Da):36,095
Last modified:June 1, 2003 - v1
Checksum:iF89F02A0783A3BDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO80319.1.
RefSeqiNP_814248.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO80319; AAO80319; EF_0464.
GeneIDi1199379.
KEGGiefa:EF0464.
PATRICi21851353. VBIEntFae7065_0429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO80319.1 .
RefSeqi NP_814248.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q838I3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF0464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO80319 ; AAO80319 ; EF_0464 .
GeneIDi 1199379.
KEGGi efa:EF0464.
PATRICi 21851353. VBIEntFae7065_0429.

Phylogenomic databases

eggNOGi COG0253.
KOi K01778.
OMAi KFNDITT.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci EFAE226185:GHI1-467-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiDAPF_ENTFA
AccessioniPrimary (citable) accession number: Q838I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3