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Q83887

- GP_NYV

UniProt

Q83887 - GP_NYV

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Protein
Envelope glycoprotein
Gene
GP
Organism
New York virus (NYV)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei652 – 6532Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host TRAF activity Source: UniProtKB-KW
  4. suppression by virus of host innate immune response Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiNew York virus (NYV)
Taxonomic identifieri44755 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Peromyscus leucopus (White-footed mouse) [TaxID: 10041]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 489472Lumenal Reviewed prediction
Add
BLAST
Transmembranei490 – 51021Helical; Reviewed prediction
Add
BLAST
Topological domaini511 – 652142Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini653 – 1108456Lumenal Reviewed prediction
Add
BLAST
Transmembranei1109 – 112921Helical; Reviewed prediction
Add
BLAST
Topological domaini1130 – 114011Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 11401123Envelope glycoprotein
PRO_0000235995Add
BLAST
Chaini18 – 652635Glycoprotein G1 By similarity
PRO_0000235996Add
BLAST
Chaini653 – 1140488Glycoprotein G2 By similarity
PRO_0000235997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi351 – 3511N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi403 – 4031N-linked (GlcNAc...); by host Reviewed prediction
Modified residuei619 – 6191Phosphotyrosine; by host By similarity
Modified residuei632 – 6321Phosphotyrosine; by host By similarity
Glycosylationi931 – 9311N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Envelope polyprotein precursor is quickly cleaved in vivo just after synthesis, presumably by host signal peptidase By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity. G1 interacts with human LYN, SYK and ZAP70.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini615 – 63824ITAM
Add
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83887-1 [UniParc]FASTAAdd to Basket

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MVGWVCISLV VLATTTAGLT RNLYELKIEC PHTVGLGQGY VTGSVETTPI     50
LLTQVTDLKI ESSCNFDLHV PSTSIQKYNQ VEWAKKSSTT ESTSAGATTF 100
EAKTKEVSLK GTCNIPVTTF EAAYKSRKTV ICYDLACNQT HCLPTVHLIA 150
PVQTCMSVRS CMIGLLSSRI QVIYEKTYCV TGQLVEGLCF IPTHTIALTQ 200
PGHTYDTMTL PITCFLVAKK LGTQLKIAVE LEKLITASGC TENSFQGYYI 250
CFLGKHSEPL FVPMMDDYRS AELFTRMVLN PRGEDHDPDQ NGQGLMRIAG 300
PITAKVPSTE TTETMQGIAF AGAPMYSSFS TLVRKADPDY VFSPGIIAES 350
NHSVCDKKTI PLTWTGFLAV SGEIEKITGC TVFCTLVGPG ASCEAYSETG 400
IFNISSPTCL VNKVQKFRGS EQRINFMCQR VDQDVIVYCN GQKKVILTKT 450
LVIGQCIYTF TSLFSLIPGV AHSLAVELCV PGLHGWATTA LLITFCFGWL 500
LIPTITMIIL KILRLLTFSC SHYSTESKFK AILERVKVEY QKTMGSMVCD 550
VCHHECETAK ELETHKKSCP EGQCPYCMTM TESTESALQA HFSICKLTNR 600
FQENLKKSLK RPEVKQGCYR TLGVFRYKSR CYVGLVWGVL LTTELIVWAA 650
SADTPLMESG WSDTAHGVGI VPMKTDLELD FALASSSSYS YRRKLVNPAN 700
KEETLPFHFQ LDKQVVHAEI QNLGHWMDGT FNIKTAFHCY GECKKYAYPW 750
QTAKCFFEKD YQYETSWGCN PPDCPGVGTG CTACGVYLDK LRSVGKAYKI 800
VSLKFTRKVC IQLGTEQTCK HIDVNDCLVT PSVKVCLIGT ISKLQPGDTL 850
LFLGPLEQGG IILKQWCTTS CVFGDPGDIM STTTGMKCPE HTGSFRKICG 900
FATTPTCEYQ GNTISGFQRM MATRDSFQSF NVTEPHITSN RLEWIDPDSS 950
IKDHINMVLN RDVSFQDLSD NPCKVDLHTQ SIDGAWGSGV GFTLVCTVGL 1000
TECANFITSI KACDSAMCYG ATVTNLLRGS NTVKVVGKGG HSGSLFKCCH 1050
DTDCTEEGLA ASPPHLDRVT GYNQIDSDKV YDDGAPPCTI KCWFTKSGEW 1100
LLGILNGNWV VVAVLIVILI LSILLFSFFC PIRGRKNKSN 1140
Length:1,140
Mass (Da):125,619
Last modified:November 1, 1996 - v1
Checksum:iBD3CCFDB0417AC42
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41W → F in strain: Isolate New York-2.
Natural varianti8 – 81S → F in strain: Isolate New York-2 and Isolate Rhode Island-1.
Natural varianti46 – 461E → G in strain: Isolate New York-2.
Natural varianti141 – 1411H → Y in strain: Isolate Rhode Island-1.
Natural varianti238 – 2381S → G in strain: Isolate New York-2.
Natural varianti261 – 2611F → S in strain: Isolate Rhode Island-1.
Natural varianti314 – 3141T → A in strain: Isolate New York-2.
Natural varianti325 – 3251M → T in strain: Isolate Rhode Island-1.
Natural varianti359 – 3591T → A in strain: Isolate Rhode Island-1.
Natural varianti394 – 3941E → K in strain: Isolate Rhode Island-1.
Natural varianti452 – 4521V → I in strain: Isolate Rhode Island-1.
Natural varianti489 – 4891T → A in strain: Isolate Rhode Island-1.
Natural varianti551 – 5511V → A in strain: Isolate Rhode Island-1.
Natural varianti589 – 5891Q → L in strain: Isolate Rhode Island-1.
Natural varianti618 – 6181C → R in strain: Isolate Rhode Island-1.
Natural varianti697 – 6971N → D in strain: Isolate New York-2.
Natural varianti794 – 7941V → G in strain: Isolate Rhode Island-1.
Natural varianti1043 – 10431G → S in strain: Isolate Rhode Island-1.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36802 Genomic RNA. Translation: AAC54560.1.
U36801 Genomic RNA. Translation: AAC54559.1.
U36803 Genomic RNA. Translation: AAC54561.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36802 Genomic RNA. Translation: AAC54560.1 .
U36801 Genomic RNA. Translation: AAC54559.1 .
U36803 Genomic RNA. Translation: AAC54561.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus."
    Hjelle B., Lee S.-W., Song W., Torrez-Martinez N., Song J.-W., Yanagihara R., Gavrilovskaya I.N., Mackow E.R.
    J. Virol. 69:8137-8141(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate New York-1, Isolate New York-2 and Isolate Rhode Island-1.
  2. "Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements."
    Geimonen E., LaMonica R., Springer K., Farooqui Y., Gavrilovskaya I.N., Mackow E.R.
    J. Virol. 77:1638-1643(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN LYN; HUMAN SYK AND HUMAN ZAP70.

Entry informationi

Entry nameiGP_NYV
AccessioniPrimary (citable) accession number: Q83887
Secondary accession number(s): Q83886, Q83888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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