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Q83887

- GP_NYV

UniProt

Q83887 - GP_NYV

Protein

Envelope glycoprotein

Gene

GP

Organism
New York virus (NYV)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei652 – 6532Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. signal transduction Source: InterPro
    3. suppression by virus of host innate immune response Source: UniProtKB-KW
    4. suppression by virus of host TRAF activity Source: UniProtKB-KW
    5. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiNew York virus (NYV)
    Taxonomic identifieri44755 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Peromyscus leucopus (White-footed mouse) [TaxID: 10041]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 11401123Envelope glycoproteinPRO_0000235995Add
    BLAST
    Chaini18 – 652635Glycoprotein G1By similarityPRO_0000235996Add
    BLAST
    Chaini653 – 1140488Glycoprotein G2By similarityPRO_0000235997Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi138 – 1381N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi351 – 3511N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi403 – 4031N-linked (GlcNAc...); by hostSequence Analysis
    Modified residuei619 – 6191Phosphotyrosine; by hostPROSITE-ProRule annotation
    Modified residuei632 – 6321Phosphotyrosine; by hostPROSITE-ProRule annotation
    Glycosylationi931 – 9311N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Envelope polyprotein precursor is quickly cleaved in vivo just after synthesis, presumably by host signal peptidase.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other By similarity. G1 interacts with human LYN, SYK and ZAP70.By similarity1 Publication

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 489472LumenalSequence AnalysisAdd
    BLAST
    Topological domaini511 – 652142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini653 – 1108456LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1130 – 114011CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei490 – 51021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1109 – 112921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini615 – 63824ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view]
    PfamiPF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
    ProDomiPD001813. Hanta_G2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS51056. ITAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q83887-1 [UniParc]FASTAAdd to Basket

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    MVGWVCISLV VLATTTAGLT RNLYELKIEC PHTVGLGQGY VTGSVETTPI     50
    LLTQVTDLKI ESSCNFDLHV PSTSIQKYNQ VEWAKKSSTT ESTSAGATTF 100
    EAKTKEVSLK GTCNIPVTTF EAAYKSRKTV ICYDLACNQT HCLPTVHLIA 150
    PVQTCMSVRS CMIGLLSSRI QVIYEKTYCV TGQLVEGLCF IPTHTIALTQ 200
    PGHTYDTMTL PITCFLVAKK LGTQLKIAVE LEKLITASGC TENSFQGYYI 250
    CFLGKHSEPL FVPMMDDYRS AELFTRMVLN PRGEDHDPDQ NGQGLMRIAG 300
    PITAKVPSTE TTETMQGIAF AGAPMYSSFS TLVRKADPDY VFSPGIIAES 350
    NHSVCDKKTI PLTWTGFLAV SGEIEKITGC TVFCTLVGPG ASCEAYSETG 400
    IFNISSPTCL VNKVQKFRGS EQRINFMCQR VDQDVIVYCN GQKKVILTKT 450
    LVIGQCIYTF TSLFSLIPGV AHSLAVELCV PGLHGWATTA LLITFCFGWL 500
    LIPTITMIIL KILRLLTFSC SHYSTESKFK AILERVKVEY QKTMGSMVCD 550
    VCHHECETAK ELETHKKSCP EGQCPYCMTM TESTESALQA HFSICKLTNR 600
    FQENLKKSLK RPEVKQGCYR TLGVFRYKSR CYVGLVWGVL LTTELIVWAA 650
    SADTPLMESG WSDTAHGVGI VPMKTDLELD FALASSSSYS YRRKLVNPAN 700
    KEETLPFHFQ LDKQVVHAEI QNLGHWMDGT FNIKTAFHCY GECKKYAYPW 750
    QTAKCFFEKD YQYETSWGCN PPDCPGVGTG CTACGVYLDK LRSVGKAYKI 800
    VSLKFTRKVC IQLGTEQTCK HIDVNDCLVT PSVKVCLIGT ISKLQPGDTL 850
    LFLGPLEQGG IILKQWCTTS CVFGDPGDIM STTTGMKCPE HTGSFRKICG 900
    FATTPTCEYQ GNTISGFQRM MATRDSFQSF NVTEPHITSN RLEWIDPDSS 950
    IKDHINMVLN RDVSFQDLSD NPCKVDLHTQ SIDGAWGSGV GFTLVCTVGL 1000
    TECANFITSI KACDSAMCYG ATVTNLLRGS NTVKVVGKGG HSGSLFKCCH 1050
    DTDCTEEGLA ASPPHLDRVT GYNQIDSDKV YDDGAPPCTI KCWFTKSGEW 1100
    LLGILNGNWV VVAVLIVILI LSILLFSFFC PIRGRKNKSN 1140
    Length:1,140
    Mass (Da):125,619
    Last modified:November 1, 1996 - v1
    Checksum:iBD3CCFDB0417AC42
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41W → F in strain: Isolate New York-2.
    Natural varianti8 – 81S → F in strain: Isolate New York-2 and Isolate Rhode Island-1.
    Natural varianti46 – 461E → G in strain: Isolate New York-2.
    Natural varianti141 – 1411H → Y in strain: Isolate Rhode Island-1.
    Natural varianti238 – 2381S → G in strain: Isolate New York-2.
    Natural varianti261 – 2611F → S in strain: Isolate Rhode Island-1.
    Natural varianti314 – 3141T → A in strain: Isolate New York-2.
    Natural varianti325 – 3251M → T in strain: Isolate Rhode Island-1.
    Natural varianti359 – 3591T → A in strain: Isolate Rhode Island-1.
    Natural varianti394 – 3941E → K in strain: Isolate Rhode Island-1.
    Natural varianti452 – 4521V → I in strain: Isolate Rhode Island-1.
    Natural varianti489 – 4891T → A in strain: Isolate Rhode Island-1.
    Natural varianti551 – 5511V → A in strain: Isolate Rhode Island-1.
    Natural varianti589 – 5891Q → L in strain: Isolate Rhode Island-1.
    Natural varianti618 – 6181C → R in strain: Isolate Rhode Island-1.
    Natural varianti697 – 6971N → D in strain: Isolate New York-2.
    Natural varianti794 – 7941V → G in strain: Isolate Rhode Island-1.
    Natural varianti1043 – 10431G → S in strain: Isolate Rhode Island-1.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36802 Genomic RNA. Translation: AAC54560.1.
    U36801 Genomic RNA. Translation: AAC54559.1.
    U36803 Genomic RNA. Translation: AAC54561.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36802 Genomic RNA. Translation: AAC54560.1 .
    U36801 Genomic RNA. Translation: AAC54559.1 .
    U36803 Genomic RNA. Translation: AAC54561.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view ]
    Pfami PF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
    ProDomi PD001813. Hanta_G2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS51056. ITAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus."
      Hjelle B., Lee S.-W., Song W., Torrez-Martinez N., Song J.-W., Yanagihara R., Gavrilovskaya I.N., Mackow E.R.
      J. Virol. 69:8137-8141(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate New York-1, Isolate New York-2 and Isolate Rhode Island-1.
    2. "Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements."
      Geimonen E., LaMonica R., Springer K., Farooqui Y., Gavrilovskaya I.N., Mackow E.R.
      J. Virol. 77:1638-1643(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HUMAN LYN; HUMAN SYK AND HUMAN ZAP70.

    Entry informationi

    Entry nameiGP_NYV
    AccessioniPrimary (citable) accession number: Q83887
    Secondary accession number(s): Q83886, Q83888
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3