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Q83887 (GP_NYV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 2 chains:

  1. Glycoprotein G1
  2. Glycoprotein G2
Gene names
Name:GP
OrganismNew York virus (NYV)
Taxonomic identifier44755 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Peromyscus leucopus (White-footed mouse) [TaxID: 10041]

Protein attributes

Sequence length1140 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis.

Subunit structure

G1 and G2 interacts with each other By similarity. G1 interacts with human LYN, SYK and ZAP70. Ref.2

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Envelope polyprotein precursor is quickly cleaved in vivo just after synthesis, presumably by host signal peptidase By similarity.

Sequence similarities

Belongs to the hantavirus envelope glycoprotein family.

Contains 1 ITAM domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 11401123Envelope glycoprotein
PRO_0000235995
Chain18 – 652635Glycoprotein G1 By similarity
PRO_0000235996
Chain653 – 1140488Glycoprotein G2 By similarity
PRO_0000235997

Regions

Topological domain18 – 489472Lumenal Potential
Transmembrane490 – 51021Helical; Potential
Topological domain511 – 652142Cytoplasmic Potential
Topological domain653 – 1108456Lumenal Potential
Transmembrane1109 – 112921Helical; Potential
Topological domain1130 – 114011Cytoplasmic Potential
Domain615 – 63824ITAM

Sites

Site652 – 6532Cleavage; by host signal peptidase By similarity

Amino acid modifications

Modified residue6191Phosphotyrosine; by host By similarity
Modified residue6321Phosphotyrosine; by host By similarity
Glycosylation1381N-linked (GlcNAc...); by host Potential
Glycosylation3511N-linked (GlcNAc...); by host Potential
Glycosylation4031N-linked (GlcNAc...); by host Potential
Glycosylation9311N-linked (GlcNAc...); by host Potential

Natural variations

Natural variant41W → F in strain: Isolate New York-2.
Natural variant81S → F in strain: Isolate New York-2 and Isolate Rhode Island-1.
Natural variant461E → G in strain: Isolate New York-2.
Natural variant1411H → Y in strain: Isolate Rhode Island-1.
Natural variant2381S → G in strain: Isolate New York-2.
Natural variant2611F → S in strain: Isolate Rhode Island-1.
Natural variant3141T → A in strain: Isolate New York-2.
Natural variant3251M → T in strain: Isolate Rhode Island-1.
Natural variant3591T → A in strain: Isolate Rhode Island-1.
Natural variant3941E → K in strain: Isolate Rhode Island-1.
Natural variant4521V → I in strain: Isolate Rhode Island-1.
Natural variant4891T → A in strain: Isolate Rhode Island-1.
Natural variant5511V → A in strain: Isolate Rhode Island-1.
Natural variant5891Q → L in strain: Isolate Rhode Island-1.
Natural variant6181C → R in strain: Isolate Rhode Island-1.
Natural variant6971N → D in strain: Isolate New York-2.
Natural variant7941V → G in strain: Isolate Rhode Island-1.
Natural variant10431G → S in strain: Isolate Rhode Island-1.

Sequences

Sequence LengthMass (Da)Tools
Q83887 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BD3CCFDB0417AC42

FASTA1,140125,619
        10         20         30         40         50         60 
MVGWVCISLV VLATTTAGLT RNLYELKIEC PHTVGLGQGY VTGSVETTPI LLTQVTDLKI 

        70         80         90        100        110        120 
ESSCNFDLHV PSTSIQKYNQ VEWAKKSSTT ESTSAGATTF EAKTKEVSLK GTCNIPVTTF 

       130        140        150        160        170        180 
EAAYKSRKTV ICYDLACNQT HCLPTVHLIA PVQTCMSVRS CMIGLLSSRI QVIYEKTYCV 

       190        200        210        220        230        240 
TGQLVEGLCF IPTHTIALTQ PGHTYDTMTL PITCFLVAKK LGTQLKIAVE LEKLITASGC 

       250        260        270        280        290        300 
TENSFQGYYI CFLGKHSEPL FVPMMDDYRS AELFTRMVLN PRGEDHDPDQ NGQGLMRIAG 

       310        320        330        340        350        360 
PITAKVPSTE TTETMQGIAF AGAPMYSSFS TLVRKADPDY VFSPGIIAES NHSVCDKKTI 

       370        380        390        400        410        420 
PLTWTGFLAV SGEIEKITGC TVFCTLVGPG ASCEAYSETG IFNISSPTCL VNKVQKFRGS 

       430        440        450        460        470        480 
EQRINFMCQR VDQDVIVYCN GQKKVILTKT LVIGQCIYTF TSLFSLIPGV AHSLAVELCV 

       490        500        510        520        530        540 
PGLHGWATTA LLITFCFGWL LIPTITMIIL KILRLLTFSC SHYSTESKFK AILERVKVEY 

       550        560        570        580        590        600 
QKTMGSMVCD VCHHECETAK ELETHKKSCP EGQCPYCMTM TESTESALQA HFSICKLTNR 

       610        620        630        640        650        660 
FQENLKKSLK RPEVKQGCYR TLGVFRYKSR CYVGLVWGVL LTTELIVWAA SADTPLMESG 

       670        680        690        700        710        720 
WSDTAHGVGI VPMKTDLELD FALASSSSYS YRRKLVNPAN KEETLPFHFQ LDKQVVHAEI 

       730        740        750        760        770        780 
QNLGHWMDGT FNIKTAFHCY GECKKYAYPW QTAKCFFEKD YQYETSWGCN PPDCPGVGTG 

       790        800        810        820        830        840 
CTACGVYLDK LRSVGKAYKI VSLKFTRKVC IQLGTEQTCK HIDVNDCLVT PSVKVCLIGT 

       850        860        870        880        890        900 
ISKLQPGDTL LFLGPLEQGG IILKQWCTTS CVFGDPGDIM STTTGMKCPE HTGSFRKICG 

       910        920        930        940        950        960 
FATTPTCEYQ GNTISGFQRM MATRDSFQSF NVTEPHITSN RLEWIDPDSS IKDHINMVLN 

       970        980        990       1000       1010       1020 
RDVSFQDLSD NPCKVDLHTQ SIDGAWGSGV GFTLVCTVGL TECANFITSI KACDSAMCYG 

      1030       1040       1050       1060       1070       1080 
ATVTNLLRGS NTVKVVGKGG HSGSLFKCCH DTDCTEEGLA ASPPHLDRVT GYNQIDSDKV 

      1090       1100       1110       1120       1130       1140 
YDDGAPPCTI KCWFTKSGEW LLGILNGNWV VVAVLIVILI LSILLFSFFC PIRGRKNKSN 

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References

[1]"Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus."
Hjelle B., Lee S.-W., Song W., Torrez-Martinez N., Song J.-W., Yanagihara R., Gavrilovskaya I.N., Mackow E.R.
J. Virol. 69:8137-8141(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate New York-1, Isolate New York-2 and Isolate Rhode Island-1.
[2]"Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements."
Geimonen E., LaMonica R., Springer K., Farooqui Y., Gavrilovskaya I.N., Mackow E.R.
J. Virol. 77:1638-1643(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HUMAN LYN; HUMAN SYK AND HUMAN ZAP70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36802 Genomic RNA. Translation: AAC54560.1.
U36801 Genomic RNA. Translation: AAC54559.1.
U36803 Genomic RNA. Translation: AAC54561.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFPIRSF003945. M_poly_HantaV. 1 hit.
ProDomPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS51056. ITAM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGP_NYV
AccessionPrimary (citable) accession number: Q83887
Secondary accession number(s): Q83886, Q83888
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families