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Q83887

- GP_NYV

UniProt

Q83887 - GP_NYV

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Protein

Envelope glycoprotein

Gene

GP

Organism
New York virus (NYV)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei652 – 6532Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host innate immune response Source: UniProtKB-KW
  4. suppression by virus of host TRAF activity Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiNew York virus (NYV)
Taxonomic identifieri44755 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Peromyscus leucopus (White-footed mouse) [TaxID: 10041]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 11401123Envelope glycoproteinPRO_0000235995Add
BLAST
Chaini18 – 652635Glycoprotein G1By similarityPRO_0000235996Add
BLAST
Chaini653 – 1140488Glycoprotein G2By similarityPRO_0000235997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi351 – 3511N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...); by hostSequence Analysis
Modified residuei619 – 6191Phosphotyrosine; by hostPROSITE-ProRule annotation
Modified residuei632 – 6321Phosphotyrosine; by hostPROSITE-ProRule annotation
Glycosylationi931 – 9311N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Envelope polyprotein precursor is quickly cleaved in vivo just after synthesis, presumably by host signal peptidase.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other (By similarity). G1 interacts with human LYN, SYK and ZAP70.By similarity1 Publication

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 489472LumenalSequence AnalysisAdd
BLAST
Topological domaini511 – 652142CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini653 – 1108456LumenalSequence AnalysisAdd
BLAST
Topological domaini1130 – 114011CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei490 – 51021HelicalSequence AnalysisAdd
BLAST
Transmembranei1109 – 112921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini615 – 63824ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83887-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MVGWVCISLV VLATTTAGLT RNLYELKIEC PHTVGLGQGY VTGSVETTPI
60 70 80 90 100
LLTQVTDLKI ESSCNFDLHV PSTSIQKYNQ VEWAKKSSTT ESTSAGATTF
110 120 130 140 150
EAKTKEVSLK GTCNIPVTTF EAAYKSRKTV ICYDLACNQT HCLPTVHLIA
160 170 180 190 200
PVQTCMSVRS CMIGLLSSRI QVIYEKTYCV TGQLVEGLCF IPTHTIALTQ
210 220 230 240 250
PGHTYDTMTL PITCFLVAKK LGTQLKIAVE LEKLITASGC TENSFQGYYI
260 270 280 290 300
CFLGKHSEPL FVPMMDDYRS AELFTRMVLN PRGEDHDPDQ NGQGLMRIAG
310 320 330 340 350
PITAKVPSTE TTETMQGIAF AGAPMYSSFS TLVRKADPDY VFSPGIIAES
360 370 380 390 400
NHSVCDKKTI PLTWTGFLAV SGEIEKITGC TVFCTLVGPG ASCEAYSETG
410 420 430 440 450
IFNISSPTCL VNKVQKFRGS EQRINFMCQR VDQDVIVYCN GQKKVILTKT
460 470 480 490 500
LVIGQCIYTF TSLFSLIPGV AHSLAVELCV PGLHGWATTA LLITFCFGWL
510 520 530 540 550
LIPTITMIIL KILRLLTFSC SHYSTESKFK AILERVKVEY QKTMGSMVCD
560 570 580 590 600
VCHHECETAK ELETHKKSCP EGQCPYCMTM TESTESALQA HFSICKLTNR
610 620 630 640 650
FQENLKKSLK RPEVKQGCYR TLGVFRYKSR CYVGLVWGVL LTTELIVWAA
660 670 680 690 700
SADTPLMESG WSDTAHGVGI VPMKTDLELD FALASSSSYS YRRKLVNPAN
710 720 730 740 750
KEETLPFHFQ LDKQVVHAEI QNLGHWMDGT FNIKTAFHCY GECKKYAYPW
760 770 780 790 800
QTAKCFFEKD YQYETSWGCN PPDCPGVGTG CTACGVYLDK LRSVGKAYKI
810 820 830 840 850
VSLKFTRKVC IQLGTEQTCK HIDVNDCLVT PSVKVCLIGT ISKLQPGDTL
860 870 880 890 900
LFLGPLEQGG IILKQWCTTS CVFGDPGDIM STTTGMKCPE HTGSFRKICG
910 920 930 940 950
FATTPTCEYQ GNTISGFQRM MATRDSFQSF NVTEPHITSN RLEWIDPDSS
960 970 980 990 1000
IKDHINMVLN RDVSFQDLSD NPCKVDLHTQ SIDGAWGSGV GFTLVCTVGL
1010 1020 1030 1040 1050
TECANFITSI KACDSAMCYG ATVTNLLRGS NTVKVVGKGG HSGSLFKCCH
1060 1070 1080 1090 1100
DTDCTEEGLA ASPPHLDRVT GYNQIDSDKV YDDGAPPCTI KCWFTKSGEW
1110 1120 1130 1140
LLGILNGNWV VVAVLIVILI LSILLFSFFC PIRGRKNKSN
Length:1,140
Mass (Da):125,619
Last modified:November 1, 1996 - v1
Checksum:iBD3CCFDB0417AC42
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41W → F in strain: Isolate New York-2.
Natural varianti8 – 81S → F in strain: Isolate New York-2 and Isolate Rhode Island-1.
Natural varianti46 – 461E → G in strain: Isolate New York-2.
Natural varianti141 – 1411H → Y in strain: Isolate Rhode Island-1.
Natural varianti238 – 2381S → G in strain: Isolate New York-2.
Natural varianti261 – 2611F → S in strain: Isolate Rhode Island-1.
Natural varianti314 – 3141T → A in strain: Isolate New York-2.
Natural varianti325 – 3251M → T in strain: Isolate Rhode Island-1.
Natural varianti359 – 3591T → A in strain: Isolate Rhode Island-1.
Natural varianti394 – 3941E → K in strain: Isolate Rhode Island-1.
Natural varianti452 – 4521V → I in strain: Isolate Rhode Island-1.
Natural varianti489 – 4891T → A in strain: Isolate Rhode Island-1.
Natural varianti551 – 5511V → A in strain: Isolate Rhode Island-1.
Natural varianti589 – 5891Q → L in strain: Isolate Rhode Island-1.
Natural varianti618 – 6181C → R in strain: Isolate Rhode Island-1.
Natural varianti697 – 6971N → D in strain: Isolate New York-2.
Natural varianti794 – 7941V → G in strain: Isolate Rhode Island-1.
Natural varianti1043 – 10431G → S in strain: Isolate Rhode Island-1.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36802 Genomic RNA. Translation: AAC54560.1.
U36801 Genomic RNA. Translation: AAC54559.1.
U36803 Genomic RNA. Translation: AAC54561.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36802 Genomic RNA. Translation: AAC54560.1 .
U36801 Genomic RNA. Translation: AAC54559.1 .
U36803 Genomic RNA. Translation: AAC54561.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus."
    Hjelle B., Lee S.-W., Song W., Torrez-Martinez N., Song J.-W., Yanagihara R., Gavrilovskaya I.N., Mackow E.R.
    J. Virol. 69:8137-8141(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate New York-1, Isolate New York-2 and Isolate Rhode Island-1.
  2. "Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements."
    Geimonen E., LaMonica R., Springer K., Farooqui Y., Gavrilovskaya I.N., Mackow E.R.
    J. Virol. 77:1638-1643(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN LYN; HUMAN SYK AND HUMAN ZAP70.

Entry informationi

Entry nameiGP_NYV
AccessioniPrimary (citable) accession number: Q83887
Secondary accession number(s): Q83886, Q83888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3