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Q83885

- VP2_NVN68

UniProt

Q83885 - VP2_NVN68

Protein

Protein VP2

Gene

ORF3

Organism
Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Minor structural protein present in one or two copies per virion. Stabilizes capsid protein VP1 by protecting it from disassembly and degradation. May play a role in RNA genome packaging.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein VP2
    Alternative name(s):
    Minor capsid protein
    Gene namesi
    ORF Names:ORF3
    OrganismiNorwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
    Taxonomic identifieri524364 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000000826: Genome

    Subcellular locationi

    Virion 1 Publication. Host cytoplasm 1 Publication

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Protein VP2PRO_0000341650Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the norovirus VP2 family.Curated

    Family and domain databases

    InterProiIPR004278. RNA_pol/capsid.
    [Graphical view]
    PfamiPF03035. RNA_capsid. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83885-1 [UniParc]FASTAAdd to Basket

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    MAQAIIGAIA ASTAGSALGA GIQVGGEAAL QSQRYQQNLQ LQENSFKHDR    50
    EMIGYQVEAS NQLLAKNLAT RYSLLRAGGL TSADAARSVA GAPVTRIVDW 100
    NGVRVSAPES SATTLRSGGF MSVPIPFASK QKQVQSSGIS NPNYSPSSIS 150
    RTTSWVESQN SSRFGNLSPY HAEALNTVWL TPPGSTASST LSSVPRGYFN 200
    TDRLPLFANN RR 212
    Length:212
    Mass (Da):22,479
    Last modified:November 1, 1996 - v1
    Checksum:i32DA45243148CA6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M87661 Genomic RNA. Translation: AAB50467.1.
    PIRiA37471.
    RefSeqiNP_056822.1. NC_001959.2.

    Genome annotation databases

    GeneIDi1491971.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M87661 Genomic RNA. Translation: AAB50467.1 .
    PIRi A37471.
    RefSeqi NP_056822.1. NC_001959.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1491971.

    Family and domain databases

    InterProi IPR004278. RNA_pol/capsid.
    [Graphical view ]
    Pfami PF03035. RNA_capsid. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and genomic organization of Norwalk virus."
      Jiang X., Wang M., Wang K., Estes M.K.
      Virology 195:51-61(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Norwalk virus open reading frame 3 encodes a minor structural protein."
      Glass P.J., White L.J., Ball J.M., Leparc-Goffart I., Hardy M.E., Estes M.K.
      J. Virol. 74:6581-6591(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    3. "The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein."
      Bertolotti-Ciarlet A., Crawford S.E., Hutson A.M., Estes M.K.
      J. Virol. 77:11603-11615(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Norovirus protein structure and function."
      Hardy M.E.
      FEMS Microbiol. Lett. 253:1-8(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiVP2_NVN68
    AccessioniPrimary (citable) accession number: Q83885
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Translated by a ribosomal termination-reinitiation process from the bicistronic mRNA coding for VP1 and VP2.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3