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Q83885

- VP2_NVN68

UniProt

Q83885 - VP2_NVN68

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Protein
Protein VP2
Gene
ORF3
Organism
Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Minor structural protein present in one or two copies per virion. Stabilizes capsid protein VP1 by protecting it from disassembly and degradation. May play a role in RNA genome packaging.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VP2
Alternative name(s):
Minor capsid protein
Gene namesi
ORF Names:ORF3
OrganismiNorwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
Taxonomic identifieri524364 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000826: Genome

Subcellular locationi

Virion. Host cytoplasm 1 Publication

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Protein VP2
PRO_0000341650Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the norovirus VP2 family.

Family and domain databases

InterProiIPR004278. RNA_pol/capsid.
[Graphical view]
PfamiPF03035. RNA_capsid. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83885-1 [UniParc]FASTAAdd to Basket

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MAQAIIGAIA ASTAGSALGA GIQVGGEAAL QSQRYQQNLQ LQENSFKHDR    50
EMIGYQVEAS NQLLAKNLAT RYSLLRAGGL TSADAARSVA GAPVTRIVDW 100
NGVRVSAPES SATTLRSGGF MSVPIPFASK QKQVQSSGIS NPNYSPSSIS 150
RTTSWVESQN SSRFGNLSPY HAEALNTVWL TPPGSTASST LSSVPRGYFN 200
TDRLPLFANN RR 212
Length:212
Mass (Da):22,479
Last modified:November 1, 1996 - v1
Checksum:i32DA45243148CA6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M87661 Genomic RNA. Translation: AAB50467.1.
PIRiA37471.
RefSeqiNP_056822.1. NC_001959.2.

Genome annotation databases

GeneIDi1491971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M87661 Genomic RNA. Translation: AAB50467.1 .
PIRi A37471.
RefSeqi NP_056822.1. NC_001959.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1491971.

Family and domain databases

InterProi IPR004278. RNA_pol/capsid.
[Graphical view ]
Pfami PF03035. RNA_capsid. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and genomic organization of Norwalk virus."
    Jiang X., Wang M., Wang K., Estes M.K.
    Virology 195:51-61(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Norwalk virus open reading frame 3 encodes a minor structural protein."
    Glass P.J., White L.J., Ball J.M., Leparc-Goffart I., Hardy M.E., Estes M.K.
    J. Virol. 74:6581-6591(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein."
    Bertolotti-Ciarlet A., Crawford S.E., Hutson A.M., Estes M.K.
    J. Virol. 77:11603-11615(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Norovirus protein structure and function."
    Hardy M.E.
    FEMS Microbiol. Lett. 253:1-8(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiVP2_NVN68
AccessioniPrimary (citable) accession number: Q83885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 1, 1996
Last modified: May 29, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Translated by a ribosomal termination-reinitiation process from the bicistronic mRNA coding for VP1 and VP2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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