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Q83885 (VP2_NVN68) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein VP2
Alternative name(s):
Minor capsid protein
Gene names
ORF Names:ORF3
OrganismNorwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US) [Reference proteome]
Taxonomic identifier524364 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Minor structural protein present in one or two copies per virion. Stabilizes capsid protein VP1 by protecting it from disassembly and degradation. May play a role in RNA genome packaging. Ref.3

Subcellular location

Virion. Host cytoplasm Ref.2.

Miscellaneous

Translated by a ribosomal termination-reinitiation process from the bicistronic mRNA coding for VP1 and VP2.

Sequence similarities

Belongs to the norovirus VP2 family.

Ontologies

Keywords
   Cellular componentHost cytoplasm
Virion
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

virion

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Protein VP2
PRO_0000341650

Sequences

Sequence LengthMass (Da)Tools
Q83885 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 32DA45243148CA6D

FASTA21222,479
        10         20         30         40         50         60 
MAQAIIGAIA ASTAGSALGA GIQVGGEAAL QSQRYQQNLQ LQENSFKHDR EMIGYQVEAS 

        70         80         90        100        110        120 
NQLLAKNLAT RYSLLRAGGL TSADAARSVA GAPVTRIVDW NGVRVSAPES SATTLRSGGF 

       130        140        150        160        170        180 
MSVPIPFASK QKQVQSSGIS NPNYSPSSIS RTTSWVESQN SSRFGNLSPY HAEALNTVWL 

       190        200        210 
TPPGSTASST LSSVPRGYFN TDRLPLFANN RR 

« Hide

References

[1]"Sequence and genomic organization of Norwalk virus."
Jiang X., Wang M., Wang K., Estes M.K.
Virology 195:51-61(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Norwalk virus open reading frame 3 encodes a minor structural protein."
Glass P.J., White L.J., Ball J.M., Leparc-Goffart I., Hardy M.E., Estes M.K.
J. Virol. 74:6581-6591(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[3]"The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein."
Bertolotti-Ciarlet A., Crawford S.E., Hutson A.M., Estes M.K.
J. Virol. 77:11603-11615(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Norovirus protein structure and function."
Hardy M.E.
FEMS Microbiol. Lett. 253:1-8(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M87661 Genomic RNA. Translation: AAB50467.1.
PIRA37471.
RefSeqNP_056822.1. NC_001959.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1491971.

Family and domain databases

InterProIPR004278. RNA_pol/capsid.
[Graphical view]
PfamPF03035. RNA_capsid. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVP2_NVN68
AccessionPrimary (citable) accession number: Q83885
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 1, 1996
Last modified: May 29, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families