Q83885 (VP2_NVN68) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein VP2

Alternative name(s):
Minor capsid protein

Gene names

ORF Names:

ORF3

Organism

Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US) [Reference proteome]

Taxonomic identifier

524364 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Caliciviridae › Norovirus › Norwalk virus › Norovirus isolates

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Minor structural protein present in one or two copies per virion. Stabilizes capsid protein VP1 by protecting it from disassembly and degradation. May play a role in RNA genome packaging. Ref.3
Subcellular location	Virion. Host cytoplasm Ref.2.
Miscellaneous	Translated by a ribosomal termination-reinitiation process from the bicistronic mRNA encoding for VP1 and VP2.
Sequence similarities	Belongs to the norovirus VP2 family.

Ontologies

Keywords
Cellular component	Host cytoplasm Virion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Protein VP2		PRO_0000341650

Sequences

	Sequence		Length	Mass (Da)
	Q83885 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 32DA45243148CA6D	FASTA	212	22,479
	10 20 30 40 50 60 MAQAIIGAIA ASTAGSALGA GIQVGGEAAL QSQRYQQNLQ LQENSFKHDR EMIGYQVEAS 70 80 90 100 110 120 NQLLAKNLAT RYSLLRAGGL TSADAARSVA GAPVTRIVDW NGVRVSAPES SATTLRSGGF 130 140 150 160 170 180 MSVPIPFASK QKQVQSSGIS NPNYSPSSIS RTTSWVESQN SSRFGNLSPY HAEALNTVWL 190 200 210 TPPGSTASST LSSVPRGYFN TDRLPLFANN RR

References

[1]	"Sequence and genomic organization of Norwalk virus." Jiang X., Wang M., Wang K., Estes M.K. Virology 195:51-61(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Norwalk virus open reading frame 3 encodes a minor structural protein." Glass P.J., White L.J., Ball J.M., Leparc-Goffart I., Hardy M.E., Estes M.K. J. Virol. 74:6581-6591(2000) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[3]	"The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein." Bertolotti-Ciarlet A., Crawford S.E., Hutson A.M., Estes M.K. J. Virol. 77:11603-11615(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"Norovirus protein structure and function." Hardy M.E. FEMS Microbiol. Lett. 253:1-8(2005) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M87661 Genomic RNA. Translation: AAB50467.1.
PIR	A37471.
RefSeq	NP_056822.1. NC_001959.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1491971.
Family and domain databases
InterPro	IPR004278. RNA_pol/capsid. [Graphical view]
Pfam	PF03035. RNA_capsid. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VP2_NVN68

Accession

Primary (citable) accession number: Q83885

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program