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Protein

Protein VP2

Gene

ORF3

Organism
Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Minor structural protein present in one or two copies per virion. Stabilizes capsid protein VP1 by protecting it from disassembly and degradation. May play a role in RNA genome packaging.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VP2
Alternative name(s):
Minor capsid protein
Gene namesi
ORF Names:ORF3
OrganismiNorwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
Taxonomic identifieri524364 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000826 Componenti: Genome

Subcellular locationi

Virion 1 Publication. Host cytoplasm 1 Publication

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Protein VP2PRO_0000341650Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the norovirus VP2 family.Curated

Family and domain databases

InterProiIPR004278. RNA_pol/capsid.
[Graphical view]
PfamiPF03035. RNA_capsid. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAIIGAIA ASTAGSALGA GIQVGGEAAL QSQRYQQNLQ LQENSFKHDR
60 70 80 90 100
EMIGYQVEAS NQLLAKNLAT RYSLLRAGGL TSADAARSVA GAPVTRIVDW
110 120 130 140 150
NGVRVSAPES SATTLRSGGF MSVPIPFASK QKQVQSSGIS NPNYSPSSIS
160 170 180 190 200
RTTSWVESQN SSRFGNLSPY HAEALNTVWL TPPGSTASST LSSVPRGYFN
210
TDRLPLFANN RR
Length:212
Mass (Da):22,479
Last modified:October 31, 1996 - v1
Checksum:i32DA45243148CA6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87661 Genomic RNA. Translation: AAB50467.1.
PIRiA37471.
RefSeqiNP_056822.1. NC_001959.2.

Genome annotation databases

GeneIDi1491971.
KEGGivg:1491971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87661 Genomic RNA. Translation: AAB50467.1.
PIRiA37471.
RefSeqiNP_056822.1. NC_001959.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1491971.
KEGGivg:1491971.

Family and domain databases

InterProiIPR004278. RNA_pol/capsid.
[Graphical view]
PfamiPF03035. RNA_capsid. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and genomic organization of Norwalk virus."
    Jiang X., Wang M., Wang K., Estes M.K.
    Virology 195:51-61(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Norwalk virus open reading frame 3 encodes a minor structural protein."
    Glass P.J., White L.J., Ball J.M., Leparc-Goffart I., Hardy M.E., Estes M.K.
    J. Virol. 74:6581-6591(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein."
    Bertolotti-Ciarlet A., Crawford S.E., Hutson A.M., Estes M.K.
    J. Virol. 77:11603-11615(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Norovirus protein structure and function."
    Hardy M.E.
    FEMS Microbiol. Lett. 253:1-8(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiVP2_NVN68
AccessioniPrimary (citable) accession number: Q83885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 2008
Last sequence update: October 31, 1996
Last modified: March 31, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Translated by a ribosomal termination-reinitiation process from the bicistronic mRNA coding for VP1 and VP2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.