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Q837N5

- SYL_ENTFA

UniProt

Q837N5 - SYL_ENTFA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-782-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:EF_0801
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligasePRO_0000152015Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226185.EF0801.

Structurei

3D structure databases

ProteinModelPortaliQ837N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q837N5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYNHKEIEK KWQKYWAKNN CFNTLDDPNK EKFYALDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI LSRMKRAQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT
110 120 130 140 150
KKNIETFRRQ INSLGFSYDW NREINTTDPE YYKWTQWIFT KLYEKGLAYE
160 170 180 190 200
AEVAVNWVPE LGTVISNEEV IDGKSERGGY DVVRRPMRQW MLKITAYADR
210 220 230 240 250
LLEDLELVDW PESIKDMQRN WIGRSEGANV TFKVAGTEES FTVFTTRPDT
260 270 280 290 300
LFGATYTVLA PELELVKKIT TPEQTAAVEA YIEETSKKSD LNRTDLAKEK
310 320 330 340 350
TGVFTGAYAI NPVNGQEIPI WIGDYVLASY GTGAIMAVPA HDERDYEFAK
360 370 380 390 400
TFGIDILPVI AGGDITTEAY TGDGPHINSD FLNGLNKAEA IAKMNEWLEE
410 420 430 440 450
NHVGKKEVSY RLRDWLFSRQ RYWGEPIPVI HWEDGTTTTV PESELPLRLP
460 470 480 490 500
VTSDIRPSGT GESPLANIDE WVNVVDPETG MKGKRETNTM PQWAGSSWYY
510 520 530 540 550
LRFIDPHNKN EIADFEKLKR WLPVDIYIGG AEHAVLHLLY ARFWHKFLYD
560 570 580 590 600
IGVVPTKEPF QKLYNQGMIL GENNEKMSKS RGNVVNPDDV VAKYGADTLR
610 620 630 640 650
LYEMFMGPLD ASIAWNENGL EGSRKFLDRV WRLIVDEEGK MRDRITTIND
660 670 680 690 700
GRLTKVYHQT VKKVTEDMAN LHFNTAISQL MVFVNEANKV DALPYEYVEG
710 720 730 740 750
FVQLLAPIAP HIGEELWQIL GNEESLTYVP WPTYDETALV EDEVEVVFQV
760 770 780 790 800
NGKLRGKQNV ARGLSKEELE QIAMNHEAVK EFIEGKTVRK VIAVPDKLVN

IVAN
Length:804
Mass (Da):91,839
Last modified:June 1, 2003 - v1
Checksum:iC79970F0DDFC14B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO80614.1.
RefSeqiNP_814544.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO80614; AAO80614; EF_0801.
GeneIDi1199694.
KEGGiefa:EF0801.
PATRICi21851984. VBIEntFae7065_0741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO80614.1 .
RefSeqi NP_814544.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q837N5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF0801.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO80614 ; AAO80614 ; EF_0801 .
GeneIDi 1199694.
KEGGi efa:EF0801.
PATRICi 21851984. VBIEntFae7065_0741.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci EFAE226185:GHI1-782-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiSYL_ENTFA
AccessioniPrimary (citable) accession number: Q837N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3