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Q837N5

- SYL_ENTFA

UniProt

Q837N5 - SYL_ENTFA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEFAE226185:GHI1-782-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:EF_0801
    OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
    Taxonomic identifieri226185 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
    ProteomesiUP000001415: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 804804Leucine--tRNA ligasePRO_0000152015Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226185.EF0801.

    Structurei

    3D structure databases

    ProteinModelPortaliQ837N5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q837N5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYNHKEIEK KWQKYWAKNN CFNTLDDPNK EKFYALDMFP YPSGQGLHVG    50
    HPEGYTATDI LSRMKRAQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT 100
    KKNIETFRRQ INSLGFSYDW NREINTTDPE YYKWTQWIFT KLYEKGLAYE 150
    AEVAVNWVPE LGTVISNEEV IDGKSERGGY DVVRRPMRQW MLKITAYADR 200
    LLEDLELVDW PESIKDMQRN WIGRSEGANV TFKVAGTEES FTVFTTRPDT 250
    LFGATYTVLA PELELVKKIT TPEQTAAVEA YIEETSKKSD LNRTDLAKEK 300
    TGVFTGAYAI NPVNGQEIPI WIGDYVLASY GTGAIMAVPA HDERDYEFAK 350
    TFGIDILPVI AGGDITTEAY TGDGPHINSD FLNGLNKAEA IAKMNEWLEE 400
    NHVGKKEVSY RLRDWLFSRQ RYWGEPIPVI HWEDGTTTTV PESELPLRLP 450
    VTSDIRPSGT GESPLANIDE WVNVVDPETG MKGKRETNTM PQWAGSSWYY 500
    LRFIDPHNKN EIADFEKLKR WLPVDIYIGG AEHAVLHLLY ARFWHKFLYD 550
    IGVVPTKEPF QKLYNQGMIL GENNEKMSKS RGNVVNPDDV VAKYGADTLR 600
    LYEMFMGPLD ASIAWNENGL EGSRKFLDRV WRLIVDEEGK MRDRITTIND 650
    GRLTKVYHQT VKKVTEDMAN LHFNTAISQL MVFVNEANKV DALPYEYVEG 700
    FVQLLAPIAP HIGEELWQIL GNEESLTYVP WPTYDETALV EDEVEVVFQV 750
    NGKLRGKQNV ARGLSKEELE QIAMNHEAVK EFIEGKTVRK VIAVPDKLVN 800
    IVAN 804
    Length:804
    Mass (Da):91,839
    Last modified:June 1, 2003 - v1
    Checksum:iC79970F0DDFC14B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO80614.1.
    RefSeqiNP_814544.1. NC_004668.1.

    Genome annotation databases

    EnsemblBacteriaiAAO80614; AAO80614; EF_0801.
    GeneIDi1199694.
    KEGGiefa:EF0801.
    PATRICi21851984. VBIEntFae7065_0741.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO80614.1 .
    RefSeqi NP_814544.1. NC_004668.1.

    3D structure databases

    ProteinModelPortali Q837N5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226185.EF0801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO80614 ; AAO80614 ; EF_0801 .
    GeneIDi 1199694.
    KEGGi efa:EF0801.
    PATRICi 21851984. VBIEntFae7065_0741.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci EFAE226185:GHI1-782-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700802 / V583.

    Entry informationi

    Entry nameiSYL_ENTFA
    AccessioniPrimary (citable) accession number: Q837N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3