Q837L2 (Q837L2_ENTFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Uridine kinase HAMAP-Rule MF_00551 RuleBase RU003825
EC=2.7.1.48 HAMAP-Rule MF_00551 RuleBase RU003825

Alternative name(s):
Cytidine monophosphokinase HAMAP-Rule MF_00551
Uridine monophosphokinase HAMAP-Rule MF_00551

Gene names

Name:	udk HAMAP-Rule MF_00551 EMBL AAO80637.1
Ordered Locus Names:	EF_0825 EMBL AAO80637.1

Organism

Enterococcus faecalis (strain ATCC 700802 / V583) [Reference proteome] [HAMAP] EMBL AAO80637.1

Taxonomic identifier

226185 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Enterococcaceae › Enterococcus › Enterococcus faecalis

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + cytidine = ADP + CMP. HAMAP-Rule MF_00551 RuleBase RU003825 ATP + uridine = ADP + UMP. HAMAP-Rule MF_00551 RuleBase RU003825
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP-Rule MF_00551 RuleBase RU003825 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP-Rule MF_00551 RuleBase RU003825
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00551.
Sequence similarities	Belongs to the uridine kinase family. HAMAP-Rule MF_00551 RuleBase RU003824

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP-Rule MF_00551
Ligand	ATP-binding RuleBase RU003528 HAMAP-Rule MF_00551 SAAS SAAS000764 Nucleotide-binding
Molecular function	Kinase RuleBase RU003528 HAMAP-Rule MF_00551 SAAS SAAS000764 EMBL AAO80637.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CTP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway UMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	13 – 20	8	ATP By similarity HAMAP-Rule MF_00551

Sequences

	Sequence		Length	Mass (Da)
	Q837L2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C68D89ED1205B839	FASTA	209	24,261
	10 20 30 40 50 60 MKDSQPIIIG VTGGSGSGKT SVSRAIFNNF PDHSIMMLEQ DSYYKDQSHL SFEERLNTNY 70 80 90 100 110 120 DHPFAFDTDL LIQHVEQLLN YQAIEKPVYD YVAHTRSTET VIQEPKEVII LEGILILEDR 130 140 150 160 170 180 RLRDLMDIKV YVDTDDDIRI IRRIKRDMEE RGRTLDSVIE QYLTVVKPMY HQFIEPTKRY 190 200 ADIIVPEGGE NHVAIDLINT KVDSILTKM

References

[1]

"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis." Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A. , Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M. Science 299:2071-2074(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700802 / V583.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016830 Genomic DNA. Translation: AAO80637.1.
RefSeq	NP_814567.1. NC_004668.1.
3D structure databases
ProteinModelPortal	Q837L2.
ModBase	Search...
Protein-protein interaction databases
STRING	226185.EF0825.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO80637; AAO80637; EF_0825.
GeneID	1199718.
KEGG	efa:EF0825.
PATRIC	21852030. VBIEntFae7065_0764.
Phylogenomic databases
KO	K00876.
OMA	DICFMRR.
ProtClustDB	PRK05480.
Enzyme and pathway databases
BioCyc	EFAE226185:GHI1-928-MONOMER.
UniPathway	UPA00574; UER00637. UPA00579; UER00640.
Family and domain databases
HAMAP	MF_00551. Uridine_kinase.
InterPro	IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view]
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q837L2_ENTFA

Accession

Primary (citable) accession number: Q837L2

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)