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Q837J0

- Q837J0_ENTFA

UniProt

Q837J0 - Q837J0_ENTFA

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Protein
Alanine racemase
Gene
alr, EF_0849, I574_01250
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei139 – 1391Substrate By similarityUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei314 – 3141Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-830-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:EF_0849Imported
ORF Names:I574_01250Imported
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)Imported
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineImported
Modified residuei40 – 401N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi226185.EF0849.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E5PX-ray2.50A/B/C1-371[»]
3E6EX-ray2.50A/B/C1-371[»]

Miscellaneous databases

EvolutionaryTraceiQ837J0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.
OMAiVSTYDVG.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q837J0-1 [UniParc]FASTAAdd to Basket

« Hide

MVVGWHRPTR LHIDTQAITE NVQKECQRLP EGTALFAVVK ANGYGHGAVE    50
SAKAAKKGGA TGFCVALLDE AIELREAGVQ DPILILSVVD LAYVPLLIQY 100
DLSVTVATQE WLEAALQQLT PESNTPLRVH LKVDTGMGRI GFLTPEETKQ 150
AVRFVQSHKE FLWEGIFTHF STADEIDTSY FEKQAGRFKA VLAVLEELPR 200
YVHVSNSATA LWHPDVPGNM IRYGVAMYGL NPSGNKLAPS YALKPALRLT 250
SELIHVKRLA AGEGIGYGET YVTEAEEWIG TVPIGYADGW LRHLQGFTVL 300
VNGKRCEIVG RVCMDQCMIR LAEEVPVGSV VTLVGKDGNE ENTLQMVAEK 350
LETIHYEVAC TFSQRIPREY N 371
Length:371
Mass (Da):40,980
Last modified:June 1, 2003 - v1
Checksum:i4DE356FE62478E0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO80661.1.
ASWP01000005 Genomic DNA. Translation: EOT88132.1.
RefSeqiNP_814591.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO80661; AAO80661; EF_0849.
EOT88132; EOT88132; I574_01250.
GeneIDi1199742.
KEGGiefa:EF0849.
PATRICi21852074. VBIEntFae7065_0786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO80661.1 .
ASWP01000005 Genomic DNA. Translation: EOT88132.1 .
RefSeqi NP_814591.1. NC_004668.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3E5P X-ray 2.50 A/B/C 1-371 [» ]
3E6E X-ray 2.50 A/B/C 1-371 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF0849.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO80661 ; AAO80661 ; EF_0849 .
EOT88132 ; EOT88132 ; I574_01250 .
GeneIDi 1199742.
KEGGi efa:EF0849.
PATRICi 21852074. VBIEntFae7065_0786.

Phylogenomic databases

KOi K01775.
OMAi VSTYDVG.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci EFAE226185:GHI1-830-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q837J0.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583 and V583Imported.
  2. "Structural insights into the alanine racemase from Enterococcus faecalis."
    Priyadarshi A., Lee E.H., Sung M.W., Nam K.H., Lee W.H., Kim E.E., Hwang K.Y.
    Biochim. Biophys. Acta 1794:1030-1040(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-40.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: V583Imported.

Entry informationi

Entry nameiQ837J0_ENTFA
AccessioniPrimary (citable) accession number: Q837J0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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