Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q837J0 (Q837J0_ENTFA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. SAAS SAAS020622 RuleBase RU004247 HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS020622 HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. RuleBase RU004247 HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site401Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2671Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1391Substrate By similarity HAMAP-Rule MF_01201
Binding site3141Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue401N6-(pyridoxal phosphate)lysine PDB 3E5P
Modified residue401N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
Q837J0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 4DE356FE62478E0B

FASTA37140,980
        10         20         30         40         50         60 
MVVGWHRPTR LHIDTQAITE NVQKECQRLP EGTALFAVVK ANGYGHGAVE SAKAAKKGGA 

        70         80         90        100        110        120 
TGFCVALLDE AIELREAGVQ DPILILSVVD LAYVPLLIQY DLSVTVATQE WLEAALQQLT 

       130        140        150        160        170        180 
PESNTPLRVH LKVDTGMGRI GFLTPEETKQ AVRFVQSHKE FLWEGIFTHF STADEIDTSY 

       190        200        210        220        230        240 
FEKQAGRFKA VLAVLEELPR YVHVSNSATA LWHPDVPGNM IRYGVAMYGL NPSGNKLAPS 

       250        260        270        280        290        300 
YALKPALRLT SELIHVKRLA AGEGIGYGET YVTEAEEWIG TVPIGYADGW LRHLQGFTVL 

       310        320        330        340        350        360 
VNGKRCEIVG RVCMDQCMIR LAEEVPVGSV VTLVGKDGNE ENTLQMVAEK LETIHYEVAC 

       370 
TFSQRIPREY N 

« Hide

References

« Hide 'large scale' references
[1]"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis."
Paulsen I., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L., Brinkac L., Beanan M., Daugherty S., DeBoy R.T., Durkin S. expand/collapse author list , Kolonay J., Madupu R., Nelson W., Vamathevan J., Tran B., Upton J., Hansen T., Shetty J., Khouri H., Utterback T., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.
Science 299:2071-2074(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700802 / V583 and V583 EMBL AAO80661.1.
[2]"Structural insights into the alanine racemase from Enterococcus faecalis."
Priyadarshi A., Lee E.H., Sung M.W., Nam K.H., Lee W.H., Kim E.E., Hwang K.Y.
Biochim. Biophys. Acta 1794:1030-1040(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-40.
[3]"The Genome Sequence of Enterococcus faecalis V583 (PacBio/Illumina hybrid assembly)."
The Broad Institute Genomics Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A., Russ C., Gilmore M., Surin D., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J. expand/collapse author list , Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: V583 EMBL EOT88132.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016830 Genomic DNA. Translation: AAO80661.1.
ASWP01000005 Genomic DNA. Translation: EOT88132.1.
RefSeqNP_814591.1. NC_004668.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3E5PX-ray2.50A/B/C1-371[»]
3E6EX-ray2.50A/B/C1-371[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226185.EF0849.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO80661; AAO80661; EF_0849.
EOT88132; EOT88132; I574_01250.
GeneID1199742.
KEGGefa:EF0849.
PATRIC21852074. VBIEntFae7065_0786.

Phylogenomic databases

KOK01775.
OMAVSTYDVG.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycEFAE226185:GHI1-830-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ837J0.

Entry information

Entry nameQ837J0_ENTFA
AccessionPrimary (citable) accession number: Q837J0
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)