Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate racemase

Gene

murI

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation2 Publications

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Proton donor/acceptorUniRule annotationBy similarity1
Active sitei185Proton donor/acceptorUniRule annotationBy similarity1

GO - Molecular functioni

  • glutamate racemase activity Source: UniProtKB-EC
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciEFAE226185:G1G0C-1111-MONOMER
BRENDAi5.1.1.3 2095
SABIO-RKiQ836J0
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation2 Publications)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:EF_1121
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000475641 – 273Glutamate racemaseAdd BLAST273

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-15642753,EBI-15642753

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-60301N
STRINGi226185.EF1121

Chemistry databases

BindingDBiQ836J0

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi7 – 14Combined sources8
Helixi17 – 26Combined sources10
Beta strandi32 – 36Combined sources5
Turni38 – 40Combined sources3
Helixi48 – 63Combined sources16
Turni64 – 66Combined sources3
Beta strandi68 – 72Combined sources5
Helixi75 – 88Combined sources14
Beta strandi93 – 97Combined sources5
Helixi98 – 107Combined sources10
Beta strandi109 – 117Combined sources9
Helixi119 – 123Combined sources5
Helixi126 – 132Combined sources7
Beta strandi138 – 144Combined sources7
Helixi148 – 153Combined sources6
Helixi160 – 170Combined sources11
Helixi171 – 173Combined sources3
Turni174 – 176Combined sources3
Beta strandi179 – 183Combined sources5
Helixi188 – 191Combined sources4
Helixi192 – 199Combined sources8
Beta strandi204 – 207Combined sources4
Helixi208 – 222Combined sources15
Beta strandi237 – 242Combined sources6
Helixi244 – 255Combined sources12
Beta strandi262 – 264Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JFOX-ray2.50A/B1-273[»]
2JFPX-ray1.98A/B1-273[»]
2VVTX-ray1.65A/B1-270[»]
ProteinModelPortaliQ836J0
SMRiQ836J0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ836J0

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 12Substrate bindingUniRule annotationCombined sources2 Publications2
Regioni43 – 44Substrate bindingUniRule annotationCombined sources2 Publications2
Regioni75 – 76Substrate bindingUniRule annotationCombined sources2 Publications2
Regioni186 – 187Substrate bindingUniRule annotationCombined sources2 Publications2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03 Bacteria
COG0796 LUCA
KOiK01776
OMAiVYGCTHY

Family and domain databases

HAMAPiMF_00258 Glu_racemase, 1 hit
InterProiView protein in InterPro
IPR015942 Asp/Glu/hydantoin_racemase
IPR001920 Asp/Glu_race
IPR018187 Asp/Glu_racemase_AS_1
IPR033134 Asp/Glu_racemase_AS_2
IPR004391 Glu_race
PANTHERiPTHR21198:SF2 PTHR21198:SF2, 1 hit
PfamiView protein in Pfam
PF01177 Asp_Glu_race, 1 hit
SUPFAMiSSF53681 SSF53681, 2 hits
TIGRFAMsiTIGR00067 glut_race, 1 hit
PROSITEiView protein in PROSITE
PS00923 ASP_GLU_RACEMASE_1, 1 hit
PS00924 ASP_GLU_RACEMASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q836J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQEAIGLI DSGVGGLTVL KEALKQLPNE RLIYLGDTAR CPYGPRPAEQ
60 70 80 90 100
VVQFTWEMAD FLLKKRIKML VIACNTATAV ALEEIKAALP IPVVGVILPG
110 120 130 140 150
ARAAVKVTKN NKIGVIGTLG TIKSASYEIA IKSKAPTIEV TSLDCPKFVP
160 170 180 190 200
IVESNQYRSS VAKKIVAETL QALQLKGLDT LILGCTHYPL LRPVIQNVMG
210 220 230 240 250
SHVTLIDSGA ETVGEVSMLL DYFDIAHTPE APTQPHEFYT TGSAKMFEEI
260 270
ASSWLGIENL KAQQIHLGGN END
Length:273
Mass (Da):29,479
Last modified:June 1, 2003 - v1
Checksum:i1F2ADF4D0B93991D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA Translation: AAO80921.1
RefSeqiNP_814851.1, NC_004668.1
WP_010706575.1, NZ_KE136528.1

Genome annotation databases

EnsemblBacteriaiAAO80921; AAO80921; EF_1121
GeneIDi1200023
KEGGiefa:EF1121
PATRICifig|226185.45.peg.2374

Similar proteinsi

Entry informationi

Entry nameiMURI_ENTFA
AccessioniPrimary (citable) accession number: Q836J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health