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Protein
Submitted name:

HD domain protein

Gene

EF_1143

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171TTPCombined sources
Metal bindingi66 – 661Calcium; via tele nitrogenCombined sources
Metal bindingi66 – 661Zinc; via tele nitrogenCombined sources
Metal bindingi110 – 1101Calcium; via tele nitrogenCombined sources
Metal bindingi110 – 1101Zinc; via tele nitrogenCombined sources
Metal bindingi111 – 1111CalciumCombined sources
Metal bindingi111 – 1111ZincCombined sources
Metal bindingi183 – 1831CalciumCombined sources
Metal bindingi183 – 1831ZincCombined sources
Binding sitei245 – 2451TTPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 562TTPCombined sources
Nucleotide bindingi206 – 2094TTPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources, Nucleotide-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1133-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
HD domain proteinImported
Gene namesi
Ordered Locus Names:EF_1143Imported
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)Imported
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1143.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O6IX-ray2.55A/B1-456[»]
3IRHX-ray2.40A/B/C/D1-456[»]
4LRLX-ray2.35A/B/C/D1-456[»]
ProteinModelPortaliQ836G9.
SMRiQ836G9. Positions 1-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 197139HDcInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105DCI. Bacteria.
COG1078. LUCA.
KOiK06885.
OMAiDERFFFP.
OrthoDBiEOG6WX4K7.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
PfamiPF01966. HD. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q836G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPYKEQRL PIEKVFRDPV HNYIHVQHQV ILDLINSAEV QRLRRIKQLG
60 70 80 90 100
TSSFTFHGAE HSRFSHSLGV YEITRRICEI FQRNYSVERL GENGWNDDER
110 120 130 140 150
LITLCAALLH DVGHGPYSHT FEHIFDTNHE AITVQIITSP ETEVYQILNR
160 170 180 190 200
VSADFPEKVA SVITKQYPNP QVVQMISSQI DADRMDYLLR DAYFTGTEYG
210 220 230 240 250
TFDLTRILRV IRPYKGGIAF AMNGMHAVED YIVSRYQMYV QVYFHPVSRG
260 270 280 290 300
MEVILDHLLH RAKELFENPE FDYDLQASLL VPFFKGDFTL QEYLKLDDGV
310 320 330 340 350
LSTYFTQWMD VPDSILGDLA KRFLMRKPLK SATFTNEKES AATIAYLREL
360 370 380 390 400
IEKVGFNPKY YTAINSSYDL PYDFYRPNKD RHRTQIELMQ KDGSLVELAT
410 420 430 440 450
VSPLVAALAG QSQGDERFYF PKEMLDQGNK KHYDLFDETY REFSSYIHNG

ALVLKK
Length:456
Mass (Da):53,074
Last modified:June 1, 2003 - v1
Checksum:i079F07C1F91F2FA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO80943.1.
RefSeqiNP_814873.1. NC_004668.1.
WP_002357999.1. NZ_KE136528.1.

Genome annotation databases

EnsemblBacteriaiAAO80943; AAO80943; EF_1143.
GeneIDi1200045.
KEGGiefa:EF1143.
PATRICi21852674. VBIEntFae7065_1068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO80943.1.
RefSeqiNP_814873.1. NC_004668.1.
WP_002357999.1. NZ_KE136528.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O6IX-ray2.55A/B1-456[»]
3IRHX-ray2.40A/B/C/D1-456[»]
4LRLX-ray2.35A/B/C/D1-456[»]
ProteinModelPortaliQ836G9.
SMRiQ836G9. Positions 1-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF1143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO80943; AAO80943; EF_1143.
GeneIDi1200045.
KEGGiefa:EF1143.
PATRICi21852674. VBIEntFae7065_1068.

Phylogenomic databases

eggNOGiENOG4105DCI. Bacteria.
COG1078. LUCA.
KOiK06885.
OMAiDERFFFP.
OrthoDBiEOG6WX4K7.

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1133-MONOMER.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
PfamiPF01966. HD. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583Imported.
  2. "Characterization of the deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity of the EF1143 protein from Enterococcus faecalis and crystal structure of the activator-substrate complex."
    Vorontsov I.I., Minasov G., Kiryukhina O., Brunzelle J.S., Shuvalova L., Anderson W.F.
    J. Biol. Chem. 286:33158-33166(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH CALCIUM AND ZINC.
  3. "Mechanisms of allosteric activation and inhibition of the deoxyribonucleoside triphosphate triphosphohydrolase from Enterococcus faecalis."
    Vorontsov I.I., Wu Y., DeLucia M., Minasov G., Mehrens J., Shuvalova L., Anderson W.F., Ahn J.
    J. Biol. Chem. 289:2815-2824(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH TTP.

Entry informationi

Entry nameiQ836G9_ENTFA
AccessioniPrimary (citable) accession number: Q836G9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 16, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.