ID   Q83623_9MONO            Unreviewed;       507 AA.
AC   Q83623;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   RecName: Full=Phosphoprotein {ECO:0000256|ARBA:ARBA00020572};
OS   Measles morbillivirus.
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Morbillivirus; Morbillivirus hominis.
OX   NCBI_TaxID=11234 {ECO:0000313|EMBL:CAA91364.1, ECO:0000313|Proteomes:UP000100252};
RN   [1] {ECO:0000313|EMBL:CAA91364.1, ECO:0000313|Proteomes:UP000100252}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edmonston B {ECO:0000313|EMBL:CAA91364.1};
RX   PubMed=2303032;
RA   Ballart I., Eschle D., Cattaneo R., Schmid A., Metzler M., Chan J.,
RA   Pifko-Hirst S., Udem S.A., Billeter M.A.;
RT   "Infectious measles virus from cloned cDNA.";
RL   EMBO J. 9:379-384(1990).
RN   [2] {ECO:0000313|EMBL:CAA91364.1, ECO:0000313|Proteomes:UP000100252}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edmonston B {ECO:0000313|EMBL:CAA91364.1};
RX   PubMed=8846771;
RA   Radecke F., Spielhofer P., Schneider H., Kaelin K., Huber M., Doetsch C.,
RA   Christiansen G., Billeter M.A.;
RT   "Rescue of measles viruses from cloned DNA.";
RL   EMBO J. 14:5773-5784(1995).
RN   [3] {ECO:0000313|Proteomes:UP000100252}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747453; DOI=10.1006/viro.1995.1214;
RA   Komase K., Rima B., Pardowitz I., Kunz C., Billeter M.A., ter Meulen V.,
RA   Baczko K.;
RT   "A comparison of nucleotide sequences of measles virus L genes derived from
RT   wild-type viruses and SSPE brain tissues.";
RL   Virology 208:795-799(1995).
RN   [4] {ECO:0007829|PDB:3ZDO}
RP   X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) OF 304-377.
RX   PubMed=23576502; DOI=10.1128/JVI.00487-13;
RA   Communie G., Crepin T., Maurin D., Jensen M.R., Blackledge M.,
RA   Ruigrok R.W.;
RT   "Structure of the tetramerization domain of measles virus phosphoprotein.";
RL   J. Virol. 87:7166-7169(2013).
RN   [5] {ECO:0007829|PDB:6HTL}
RP   X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 304-375 IN COMPLEX WITH CA(2+).
RX   PubMed=31086822; DOI=10.1126/sciadv.aaw3702;
RA   Bloyet L.M., Schramm A., Lazert C., Raynal B., Hologne M., Walker O.,
RA   Longhi S., Gerlier D.;
RT   "Regulation of measles virus gene expression by P protein coiled-coil
RT   properties.";
RL   Sci. Adv. 5:eaaw3702-eaaw3702(2019).
CC   -!- SIMILARITY: Belongs to the morbillivirus P protein family.
CC       {ECO:0000256|ARBA:ARBA00008617}.
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DR   EMBL; Z66517; CAA91364.1; -; Genomic_RNA.
DR   PDB; 3ZDO; X-ray; 2.07 A; A/B/C/D/E/F/G/H=304-377.
DR   PDB; 6HTL; X-ray; 2.30 A; A=304-375.
DR   PDBsum; 3ZDO; -.
DR   PDBsum; 6HTL; -.
DR   SMR; Q83623; -.
DR   Proteomes; UP000100252; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   CDD; cd21031; MEV_P-protein-C_like; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   InterPro; IPR004897; P/V_Pprotein_paramyxoviral.
DR   InterPro; IPR028243; Paramyxo_P/V_N.
DR   InterPro; IPR016075; RNA_pol_Pprot-P_XD_paramyxovir.
DR   Pfam; PF03210; Paramyx_P_V_C; 1.
DR   Pfam; PF13825; Paramyxo_P_V_N; 1.
DR   SUPFAM; SSF101089; Phosphoprotein XD domain; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3ZDO, ECO:0007829|PDB:6HTL};
KW   Calcium {ECO:0007829|PDB:6HTL}; Metal-binding {ECO:0007829|PDB:6HTL};
KW   RNA editing {ECO:0000256|ARBA:ARBA00022495}.
FT   DOMAIN          4..312
FT                   /note="Paramyxovirus structural protein P/V N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13825"
FT   REGION          40..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         314
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:6HTL"
SQ   SEQUENCE   507 AA;  53879 MW;  E85C851EA4B94F33 CRC64;
     MAEEQARHVK NGLECIRALK AEPIGSLAIE EAMAAWSEIS DNPGQERATC REEKAGSSGL
     SKPCLSAIGS TEGGAPRIRG QGPGESDDDA ETLGIPPRNL QASSTGLQCH YVYDHSGEAV
     KGIQDADSIM VQSGLDGDST LSGGDNESEN SDVDIGEPDT EGYAITDRGS APISMGFRAS
     DVETAEGGEI HELLRLQSRG NNFPKLGKTL NVPPPPDPGR ASTSGTPIKK GTDARLASFG
     TEIASSLTGG ATQCARKSPS EPSGPGAPAG NVPECVSNAA LIQEWTPESG TTISPRSQNN
     EEGGDHYDDE LFSDVQDIKT ALAKIHEDNQ KIISKLESLL LLKGEVESIK KQINRQNISI
     STLEGHLSSI MIAIPGLGKD PNDPTADVEI NPDLKPIIGR DSGRALAEVL KKPVASRQLQ
     GMTNGRTSSR GQLLKEFQLK PIGKKMSSAV GFVPDTGPAS RSVIRSIIKS SRLEEDRKRY
     LMTLLDDIKG ANDLAKFHQM LMKIIMK
//