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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei291Proton donorUniRule annotation1
Active sitei312UniRule annotation1
Active sitei426UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:EF_1416
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806391 – 449Glucose-6-phosphate isomeraseAdd BLAST449

Proteomic databases

PRIDEiQ835G1.

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1416.

Structurei

3D structure databases

ProteinModelPortaliQ835G1.
SMRiQ835G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
KOiK01810.
OMAiNNIGEDY.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q835G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHIQLDYSK LAPFVADHEL EYMQTQVTAV DKALREGTGA GNDFTGWIDL
60 70 80 90 100
PENYDKEEFA RIKKAAAKIQ SDSEVLVVIG IGGSYLGARA AIEFLTHSFN
110 120 130 140 150
NLLSKEERKA PQIFFAGNSI SSTYLADLIN VIGDRDFSVN VISKSGTTTE
160 170 180 190 200
PAIAFRVFKE LLINKYGKEE ANKRIYATTD RAKGAVKVEA DAEGWETFVI
210 220 230 240 250
PDDVGGRFTV LTPVGLLPIA VSGADIDRLM EGANDARKEY GATSDLKENQ
260 270 280 290 300
AYQYAALRNI LYRKGKTTEM LINYEPGMHY FSEWWKQLYG ESEGKDGKGI
310 320 330 340 350
FPAAADFSTD LHSMGQYVQE GMRNLFETVV KIENPRHSIS IPEQNEDLDG
360 370 380 390 400
LGYLQGKEID FVNTKAFEGT LLAHTDGGVP NMIVKVPTMD AYSLGYVMYF
410 420 430 440
FEIAVGISGY LNGVNPFDQP GVEAYKRNMF ALLGKPGFEE LAKDLNARL
Length:449
Mass (Da):49,734
Last modified:June 1, 2003 - v1
Checksum:i1DF1A5B5D483D336
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO81207.1.
RefSeqiNP_815137.1. NC_004668.1.
WP_002357685.1. NZ_KE136528.1.

Genome annotation databases

EnsemblBacteriaiAAO81207; AAO81207; EF_1416.
GeneIDi1200316.
KEGGiefa:EF1416.
PATRICifig|226185.45.peg.2085.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiG6PI_ENTFA
AccessioniPrimary (citable) accession number: Q835G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families