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Q834E3 (PYRF_ENTFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:EF_1713
OrganismEnterococcus faecalis (strain ATCC 700802 / V583) [Reference proteome] [HAMAP]
Taxonomic identifier226185 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134542

Regions

Region60 – 6910Substrate binding By similarity

Sites

Active site621Proton donor By similarity
Binding site101Substrate By similarity
Binding site331Substrate By similarity
Binding site1231Substrate By similarity
Binding site1851Substrate By similarity
Binding site1941Substrate By similarity
Binding site2141Substrate; via amide nitrogen By similarity
Binding site2151Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q834E3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 49CE4B64872B1294

FASTA23726,036
        10         20         30         40         50         60 
MHDRPIIALD FPTQKEVAVF LEKFPKEEAL FVKVGMELFY AEGPAIVRWL KEQGHDVFLD 

        70         80         90        100        110        120 
LKLHDIPNTV EKAMTNLAKL GVAITNVHAA GGVRMMQAAK EGLIKGTQPG AKVPELIAVT 

       130        140        150        160        170        180 
QLTSTSEEEM HHDQLINVPL ETSVIHYAKC AEKAGLDGVV CSALEARGIQ EATKQTFICL 

       190        200        210        220        230 
TPGIRPAGSA VGDQQRVVTP QHAREIGSTY IVVGRPITQA ENPYEAYQEI KKDWSEK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016830 Genomic DNA. Translation: AAO81489.1.
RefSeqNP_815419.1. NC_004668.1.

3D structure databases

ProteinModelPortalQ834E3.
SMRQ834E3. Positions 1-235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226185.EF1713.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO81489; AAO81489; EF_1713.
GeneID1200605.
KEGGefa:EF1713.
PATRIC21853770. VBIEntFae7065_1611.

Phylogenomic databases

eggNOGCOG0284.
KOK01591.
OMASAYHAIK.
OrthoDBEOG6N6815.

Enzyme and pathway databases

BioCycEFAE226185:GHI1-1691-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_ENTFA
AccessionPrimary (citable) accession number: Q834E3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways