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Q834D6

- FTHS_ENTFA

UniProt

Q834D6 - FTHS_ENTFA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEFAE226185:GHI1-1703-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:EF_1725
    OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
    Taxonomic identifieri226185 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
    ProteomesiUP000001415: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000199347Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226185.EF1725.

    Structurei

    3D structure databases

    ProteinModelPortaliQ834D6.
    SMRiQ834D6. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q834D6-1 [UniParc]FASTAAdd to Basket

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    MKTDINIAQA ATLKPIQEIA ETIGLSEDSL ELYGKYKAKI DFPTLQSLEA    50
    QPEGKLILVT SINPTPAGEG KSTVTIGLGD ALNQINKKTV IALREPSLGP 100
    VMGIKGGATG GGYAQVLPME EINLHFTGDM HAITTANNAL AALLDNHLQQ 150
    GNELKIDSRR VIWKRAVDLN DRALRQVVVG LGGPFQGVPR EDGFDITVAS 200
    EIMAILCLAQ NLTDLKERLS RIIVAYNDQR EPVTVKDLNV AGALTLLLKD 250
    ALKPNLVQTI EGTPAFVHGG PFANIAHGCN SILATKTALH LGDYVVTEAG 300
    FGGDLGGEKF LDIKVPSLGK APDAVVIVAT IRALKMHGGL AKDQLAEENL 350
    PALQKGFANL EKHIQNMQRY DVPVVVAINE FTQDTEKEIQ LLKEACQALG 400
    VPVELTSVWA QGGAGGTNLA KTVVAEIEAD TKQFQPLYNP RQTIEEKIQA 450
    IVQTIYGGEQ AIFSPKAQKQ IADFTKNGWD QLPICMAKTQ YSLSDDPQKL 500
    GRPEGFTITI RELVPKIGAG FIVALTGDIL TMPGLPKVPA ALNMDVDETG 550
    QASGLF 556
    Length:556
    Mass (Da):59,594
    Last modified:June 1, 2003 - v1
    Checksum:i198C0B40248C1F2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO81500.1.
    RefSeqiNP_815430.1. NC_004668.1.

    Genome annotation databases

    EnsemblBacteriaiAAO81500; AAO81500; EF_1725.
    GeneIDi1200617.
    KEGGiefa:EF1725.
    PATRICi21853794. VBIEntFae7065_1623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO81500.1 .
    RefSeqi NP_815430.1. NC_004668.1.

    3D structure databases

    ProteinModelPortali Q834D6.
    SMRi Q834D6. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226185.EF1725.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO81500 ; AAO81500 ; EF_1725 .
    GeneIDi 1200617.
    KEGGi efa:EF1725.
    PATRICi 21853794. VBIEntFae7065_1623.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci EFAE226185:GHI1-1703-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700802 / V583.

    Entry informationi

    Entry nameiFTHS_ENTFA
    AccessioniPrimary (citable) accession number: Q834D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3