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Q834D6

- FTHS_ENTFA

UniProt

Q834D6 - FTHS_ENTFA

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, EF_1725
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1703-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:EF_1725
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199347Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1725.

Structurei

3D structure databases

ProteinModelPortaliQ834D6.
SMRiQ834D6. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q834D6-1 [UniParc]FASTAAdd to Basket

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MKTDINIAQA ATLKPIQEIA ETIGLSEDSL ELYGKYKAKI DFPTLQSLEA    50
QPEGKLILVT SINPTPAGEG KSTVTIGLGD ALNQINKKTV IALREPSLGP 100
VMGIKGGATG GGYAQVLPME EINLHFTGDM HAITTANNAL AALLDNHLQQ 150
GNELKIDSRR VIWKRAVDLN DRALRQVVVG LGGPFQGVPR EDGFDITVAS 200
EIMAILCLAQ NLTDLKERLS RIIVAYNDQR EPVTVKDLNV AGALTLLLKD 250
ALKPNLVQTI EGTPAFVHGG PFANIAHGCN SILATKTALH LGDYVVTEAG 300
FGGDLGGEKF LDIKVPSLGK APDAVVIVAT IRALKMHGGL AKDQLAEENL 350
PALQKGFANL EKHIQNMQRY DVPVVVAINE FTQDTEKEIQ LLKEACQALG 400
VPVELTSVWA QGGAGGTNLA KTVVAEIEAD TKQFQPLYNP RQTIEEKIQA 450
IVQTIYGGEQ AIFSPKAQKQ IADFTKNGWD QLPICMAKTQ YSLSDDPQKL 500
GRPEGFTITI RELVPKIGAG FIVALTGDIL TMPGLPKVPA ALNMDVDETG 550
QASGLF 556
Length:556
Mass (Da):59,594
Last modified:June 1, 2003 - v1
Checksum:i198C0B40248C1F2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO81500.1.
RefSeqiNP_815430.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO81500; AAO81500; EF_1725.
GeneIDi1200617.
KEGGiefa:EF1725.
PATRICi21853794. VBIEntFae7065_1623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO81500.1 .
RefSeqi NP_815430.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q834D6.
SMRi Q834D6. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF1725.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO81500 ; AAO81500 ; EF_1725 .
GeneIDi 1200617.
KEGGi efa:EF1725.
PATRICi 21853794. VBIEntFae7065_1623.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci EFAE226185:GHI1-1703-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiFTHS_ENTFA
AccessioniPrimary (citable) accession number: Q834D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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