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Q834D6 (FTHS_ENTFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:EF_1725
OrganismEnterococcus faecalis (strain ATCC 700802 / V583) [Reference proteome] [HAMAP]
Taxonomic identifier226185 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199347

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q834D6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 198C0B40248C1F2B

FASTA55659,594
        10         20         30         40         50         60 
MKTDINIAQA ATLKPIQEIA ETIGLSEDSL ELYGKYKAKI DFPTLQSLEA QPEGKLILVT 

        70         80         90        100        110        120 
SINPTPAGEG KSTVTIGLGD ALNQINKKTV IALREPSLGP VMGIKGGATG GGYAQVLPME 

       130        140        150        160        170        180 
EINLHFTGDM HAITTANNAL AALLDNHLQQ GNELKIDSRR VIWKRAVDLN DRALRQVVVG 

       190        200        210        220        230        240 
LGGPFQGVPR EDGFDITVAS EIMAILCLAQ NLTDLKERLS RIIVAYNDQR EPVTVKDLNV 

       250        260        270        280        290        300 
AGALTLLLKD ALKPNLVQTI EGTPAFVHGG PFANIAHGCN SILATKTALH LGDYVVTEAG 

       310        320        330        340        350        360 
FGGDLGGEKF LDIKVPSLGK APDAVVIVAT IRALKMHGGL AKDQLAEENL PALQKGFANL 

       370        380        390        400        410        420 
EKHIQNMQRY DVPVVVAINE FTQDTEKEIQ LLKEACQALG VPVELTSVWA QGGAGGTNLA 

       430        440        450        460        470        480 
KTVVAEIEAD TKQFQPLYNP RQTIEEKIQA IVQTIYGGEQ AIFSPKAQKQ IADFTKNGWD 

       490        500        510        520        530        540 
QLPICMAKTQ YSLSDDPQKL GRPEGFTITI RELVPKIGAG FIVALTGDIL TMPGLPKVPA 

       550 
ALNMDVDETG QASGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016830 Genomic DNA. Translation: AAO81500.1.
RefSeqNP_815430.1. NC_004668.1.

3D structure databases

ProteinModelPortalQ834D6.
SMRQ834D6. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226185.EF1725.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO81500; AAO81500; EF_1725.
GeneID1200617.
KEGGefa:EF1725.
PATRIC21853794. VBIEntFae7065_1623.

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycEFAE226185:GHI1-1703-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ENTFA
AccessionPrimary (citable) accession number: Q834D6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways