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Protein

Fiber protein

Gene

L5

Organism
Porcine adenovirus A serotype 3 (PAdV-3) (Porcine adenovirus 3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host adhesion receptor, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Fiber protein
Short name:
SPIKE
Alternative name(s):
Protein IV
Gene namesi
ORF Names:L5
OrganismiPorcine adenovirus A serotype 3 (PAdV-3) (Porcine adenovirus 3)
Taxonomic identifieri35265 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusPorcine mastadenovirus A
Virus hostiSus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

  • Virion By similarity
  • Host nucleus By similarity

  • Note: Anchored to the pentons, protrudes from the virion surface.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002218111 – 448Fiber proteinAdd BLAST448

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homotrimer. Interacts (via N-terminal tail region) with pentons (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ83457.
SMRiQ83457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion.By similarity

Sequence similaritiesi

Belongs to the adenoviridae fiber family.Curated

Family and domain databases

Gene3Di2.10.25.20. 1 hit.
2.60.90.10. 1 hit.
InterProiIPR000931. Adeno_fibre.
IPR000978. Adeno_fibre_knob.
IPR000939. Adenobir_fibre_prot_rpt/shaft.
IPR008982. Adenovirus_pIV-rel_att.
IPR009013. Attachment_protein_shaft_dom.
[Graphical view]
PfamiPF00608. Adeno_shaft. 5 hits.
[Graphical view]
PRINTSiPR00307. ADENOVSFIBRE.
SUPFAMiSSF49835. SSF49835. 1 hit.
SSF51225. SSF51225. 2 hits.

Sequencei

Sequence statusi: Complete.

Q83457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPKKQKREL PEDFDPVYPY DVPQLQINPP FVSGDGFNQS VDGVLSLHIA
60 70 80 90 100
PPLVFDNTRA LTLAFGGGLQ LSGKQLVVAT EGSGLTTNPD GKLVLKVKSP
110 120 130 140 150
ITLTAEGISL SLGPGLSNSE TGLSLQVTAP LQFQGNALTL PLAAGLQNTD
160 170 180 190 200
GGMGVKLGSG LTTDNSQAVT VQVGNGLQLN GEGQLTVPAT APLVSGSAGI
210 220 230 240 250
SFNYSSNDFV LDNDSLSLRP KAISVTPPLQ STEDTISLNY SNDFSVDNGA
260 270 280 290 300
LTLAPTFKPY TLWTGASPTA NVILTNTTTP NGTFFLCLTR VGGLVLGSFA
310 320 330 340 350
LKSSIDLTSM TKKVNFIFDG AGRLQSDSTY KGRFGFRSND SVIEPTAAGL
360 370 380 390 400
SPAWLMPSTF IYPRNTSGSS LTSFVYINQT YVHVDIKVNT LSTNGYSLEF
410 420 430 440
NFQNMSFSAP FSTSYGTFCY VPRRTTHRPR HGPFSLRERR HLFQLLQQ
Length:448
Mass (Da):47,846
Last modified:November 1, 1996 - v1
Checksum:i8B929F41D16A0FA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083132 Genomic DNA. Translation: AAC99449.1.
AJ237815 Genomic DNA. Translation: CAB41035.1.
AB026117 Genomic DNA. Translation: BAA76973.1.
RefSeqiYP_009220.1. AC_000189.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083132 Genomic DNA. Translation: AAC99449.1.
AJ237815 Genomic DNA. Translation: CAB41035.1.
AB026117 Genomic DNA. Translation: BAA76973.1.
RefSeqiYP_009220.1. AC_000189.1.

3D structure databases

ProteinModelPortaliQ83457.
SMRiQ83457.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.10.25.20. 1 hit.
2.60.90.10. 1 hit.
InterProiIPR000931. Adeno_fibre.
IPR000978. Adeno_fibre_knob.
IPR000939. Adenobir_fibre_prot_rpt/shaft.
IPR008982. Adenovirus_pIV-rel_att.
IPR009013. Attachment_protein_shaft_dom.
[Graphical view]
PfamiPF00608. Adeno_shaft. 5 hits.
[Graphical view]
PRINTSiPR00307. ADENOVSFIBRE.
SUPFAMiSSF49835. SSF49835. 1 hit.
SSF51225. SSF51225. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSPIKE_ADEP3
AccessioniPrimary (citable) accession number: Q83457
Secondary accession number(s): Q9YTR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell (By similarity).By similarity

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.