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Q833Z3

- PUR9_ENTFA

UniProt

Q833Z3 - PUR9_ENTFA

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1753-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:EF_1778
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Bifunctional purine biosynthesis protein PurHPRO_1000018889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1778.

Structurei

3D structure databases

ProteinModelPortaliQ833Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q833Z3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKRALISVS DKTGVTTFAA GLVANGFEII STGGTRTVLE EAGVPTLAID
60 70 80 90 100
DITGFPEMLD GRVKTLHPNI HGGLLAKRGN QAHQKALTEQ GIHFIDLVVV
110 120 130 140 150
NLYPFKETIL KPAISEAEAI EMIDIGGPSM LRSAAKNYQD VTAVVDPSDY
160 170 180 190 200
EQVLSEISST GTSQLATRKR LAAKVFRHTA AYDALIADYL TTQVGETEPE
210 220 230 240 250
KQTLTYERKQ TLRYGENSHQ QATFYQSVVP VSLSIASARQ LHGKELSYNN
260 270 280 290 300
IRDADAALRI ASEFTEPTVV AVKHMNPCGI GTGKTILAAY RQAFEADPVS
310 320 330 340 350
IFGGIVVLNR PVDQATAAEM HQIFLEIIIA PSFEEEALAL LSQKKNLRLL
360 370 380 390 400
TLDFHAQEKK AVELVSVMGG LLIQEQDTVV ENDQAWQVVT ERQPTPAERD
410 420 430 440 450
ALNFAWKAVK HVKSNAIVLA NESQTVGIGA GQMNRIGSVK IAVDQAQAAG
460 470 480 490 500
KLQGAVLASD AFFPMADSVE YAAQHGIQAI IQPGGSIKDQ ASIDLANHYG
510
IAMIFTGTRH FKH
Length:513
Mass (Da):55,523
Last modified:June 1, 2003 - v1
Checksum:i2D318C4783E1AA33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO81549.1.
RefSeqiNP_815479.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO81549; AAO81549; EF_1778.
GeneIDi1200667.
KEGGiefa:EF1778.
PATRICi21853892. VBIEntFae7065_1672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO81549.1 .
RefSeqi NP_815479.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q833Z3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF1778.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO81549 ; AAO81549 ; EF_1778 .
GeneIDi 1200667.
KEGGi efa:EF1778.
PATRICi 21853892. VBIEntFae7065_1672.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci EFAE226185:GHI1-1753-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiPUR9_ENTFA
AccessioniPrimary (citable) accession number: Q833Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3