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Q833Z3 (PUR9_ENTFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:EF_1778
OrganismEnterococcus faecalis (strain ATCC 700802 / V583) [Reference proteome] [HAMAP]
Taxonomic identifier226185 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018889

Sequences

Sequence LengthMass (Da)Tools
Q833Z3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 2D318C4783E1AA33

FASTA51355,523
        10         20         30         40         50         60 
MTKRALISVS DKTGVTTFAA GLVANGFEII STGGTRTVLE EAGVPTLAID DITGFPEMLD 

        70         80         90        100        110        120 
GRVKTLHPNI HGGLLAKRGN QAHQKALTEQ GIHFIDLVVV NLYPFKETIL KPAISEAEAI 

       130        140        150        160        170        180 
EMIDIGGPSM LRSAAKNYQD VTAVVDPSDY EQVLSEISST GTSQLATRKR LAAKVFRHTA 

       190        200        210        220        230        240 
AYDALIADYL TTQVGETEPE KQTLTYERKQ TLRYGENSHQ QATFYQSVVP VSLSIASARQ 

       250        260        270        280        290        300 
LHGKELSYNN IRDADAALRI ASEFTEPTVV AVKHMNPCGI GTGKTILAAY RQAFEADPVS 

       310        320        330        340        350        360 
IFGGIVVLNR PVDQATAAEM HQIFLEIIIA PSFEEEALAL LSQKKNLRLL TLDFHAQEKK 

       370        380        390        400        410        420 
AVELVSVMGG LLIQEQDTVV ENDQAWQVVT ERQPTPAERD ALNFAWKAVK HVKSNAIVLA 

       430        440        450        460        470        480 
NESQTVGIGA GQMNRIGSVK IAVDQAQAAG KLQGAVLASD AFFPMADSVE YAAQHGIQAI 

       490        500        510 
IQPGGSIKDQ ASIDLANHYG IAMIFTGTRH FKH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016830 Genomic DNA. Translation: AAO81549.1.
RefSeqNP_815479.1. NC_004668.1.

3D structure databases

ProteinModelPortalQ833Z3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226185.EF1778.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO81549; AAO81549; EF_1778.
GeneID1200667.
KEGGefa:EF1778.
PATRIC21853892. VBIEntFae7065_1672.

Phylogenomic databases

eggNOGCOG0138.
KOK00602.
OMAGIGQADN.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycEFAE226185:GHI1-1753-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_ENTFA
AccessionPrimary (citable) accession number: Q833Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways