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Q833Z3

- PUR9_ENTFA

UniProt

Q833Z3 - PUR9_ENTFA

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, EF_1778
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1753-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:EF_1778
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1778.

Structurei

3D structure databases

ProteinModelPortaliQ833Z3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q833Z3-1 [UniParc]FASTAAdd to Basket

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MTKRALISVS DKTGVTTFAA GLVANGFEII STGGTRTVLE EAGVPTLAID    50
DITGFPEMLD GRVKTLHPNI HGGLLAKRGN QAHQKALTEQ GIHFIDLVVV 100
NLYPFKETIL KPAISEAEAI EMIDIGGPSM LRSAAKNYQD VTAVVDPSDY 150
EQVLSEISST GTSQLATRKR LAAKVFRHTA AYDALIADYL TTQVGETEPE 200
KQTLTYERKQ TLRYGENSHQ QATFYQSVVP VSLSIASARQ LHGKELSYNN 250
IRDADAALRI ASEFTEPTVV AVKHMNPCGI GTGKTILAAY RQAFEADPVS 300
IFGGIVVLNR PVDQATAAEM HQIFLEIIIA PSFEEEALAL LSQKKNLRLL 350
TLDFHAQEKK AVELVSVMGG LLIQEQDTVV ENDQAWQVVT ERQPTPAERD 400
ALNFAWKAVK HVKSNAIVLA NESQTVGIGA GQMNRIGSVK IAVDQAQAAG 450
KLQGAVLASD AFFPMADSVE YAAQHGIQAI IQPGGSIKDQ ASIDLANHYG 500
IAMIFTGTRH FKH 513
Length:513
Mass (Da):55,523
Last modified:June 1, 2003 - v1
Checksum:i2D318C4783E1AA33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO81549.1.
RefSeqiNP_815479.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO81549; AAO81549; EF_1778.
GeneIDi1200667.
KEGGiefa:EF1778.
PATRICi21853892. VBIEntFae7065_1672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO81549.1 .
RefSeqi NP_815479.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q833Z3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 226185.EF1778.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO81549 ; AAO81549 ; EF_1778 .
GeneIDi 1200667.
KEGGi efa:EF1778.
PATRICi 21853892. VBIEntFae7065_1672.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci EFAE226185:GHI1-1753-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiPUR9_ENTFA
AccessioniPrimary (citable) accession number: Q833Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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