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Q833Z1

- PUR5_ENTFA

UniProt

Q833Z1 - PUR5_ENTFA

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, EF_1780
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1755-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:EF_1780
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000148212Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1780.

Structurei

3D structure databases

ProteinModelPortaliQ833Z1.
SMRiQ833Z1. Positions 13-333.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiNPQENDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q833Z1-1 [UniParc]FASTAAdd to Basket

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MENAYSKAGV NVEAGYEVVE RIQKHSQKTQ RTGTLGMLGG FGGCFDLSSY    50
KLKEPVLVSG TDGVGTKLLL AIEEQKHETI GIDCVAMCVN DVVAQGAEPL 100
YFLDYLALGT VNPAKVEAIV AGVAAGCCEA NAALIGGETA EMPDMYEADA 150
YDVAGFAVGI AEKSQLLTPS NVKEGDFLIG LPSSGLHSNG YSLVRNIFFK 200
KHSFKTTDKL PELAPKTLGE ELLTPTKIYV KELLPLLKAG LVHGAAHITG 250
GGFLENLPRM FSSALAAEIQ LNSWPVLPIF KLIQKYGEIP PEEMYEIFNM 300
GLGMILAVSP EHVEKVQELL PEAFEIGRLV PRKTKAVIFK EAL 343
Length:343
Mass (Da):36,931
Last modified:June 1, 2003 - v1
Checksum:iAD7FD0DADB4CAC2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO81551.1.
RefSeqiNP_815481.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO81551; AAO81551; EF_1780.
GeneIDi1200669.
KEGGiefa:EF1780.
PATRICi21853896. VBIEntFae7065_1674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO81551.1 .
RefSeqi NP_815481.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q833Z1.
SMRi Q833Z1. Positions 13-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF1780.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO81551 ; AAO81551 ; EF_1780 .
GeneIDi 1200669.
KEGGi efa:EF1780.
PATRICi 21853896. VBIEntFae7065_1674.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi NPQENDI.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci EFAE226185:GHI1-1755-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiPUR5_ENTFA
AccessioniPrimary (citable) accession number: Q833Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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