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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurS (purS), Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE226185:G1G0C-1755-MONOMER
UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:EF_1780
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001482121 – 343Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST343

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1780

Structurei

3D structure databases

ProteinModelPortaliQ833Z1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
KOiK01933
OMAiNHCVNDI

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q833Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENAYSKAGV NVEAGYEVVE RIQKHSQKTQ RTGTLGMLGG FGGCFDLSSY
60 70 80 90 100
KLKEPVLVSG TDGVGTKLLL AIEEQKHETI GIDCVAMCVN DVVAQGAEPL
110 120 130 140 150
YFLDYLALGT VNPAKVEAIV AGVAAGCCEA NAALIGGETA EMPDMYEADA
160 170 180 190 200
YDVAGFAVGI AEKSQLLTPS NVKEGDFLIG LPSSGLHSNG YSLVRNIFFK
210 220 230 240 250
KHSFKTTDKL PELAPKTLGE ELLTPTKIYV KELLPLLKAG LVHGAAHITG
260 270 280 290 300
GGFLENLPRM FSSALAAEIQ LNSWPVLPIF KLIQKYGEIP PEEMYEIFNM
310 320 330 340
GLGMILAVSP EHVEKVQELL PEAFEIGRLV PRKTKAVIFK EAL
Length:343
Mass (Da):36,931
Last modified:June 1, 2003 - v1
Checksum:iAD7FD0DADB4CAC2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA Translation: AAO81551.1
RefSeqiNP_815481.1, NC_004668.1
WP_002369275.1, NZ_KE136528.1

Genome annotation databases

EnsemblBacteriaiAAO81551; AAO81551; EF_1780
GeneIDi1200669
KEGGiefa:EF1780
PATRICifig|226185.45.peg.1735

Similar proteinsi

Entry informationi

Entry nameiPUR5_ENTFA
AccessioniPrimary (citable) accession number: Q833Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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