Q833W9 (LACC_ENTFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tagatose-6-phosphate kinase
EC=2.7.1.144

Alternative name(s):
Phosphotagatokinase

Gene names

Name:	lacC
Ordered Locus Names:	EF_1806

Organism

Enterococcus faecalis (Streptococcus faecalis)

Taxonomic identifier

1351 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Enterococcaceae › Enterococcus

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate. HAMAP MF_01557
Pathway	Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2. HAMAP MF_01557
Sequence similarities	Belongs to the carbohydrate kinase pfkB family. LacC subfamily.

Ontologies

Keywords
Biological process	Lactose metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: InterPro
Molecular function	1-phosphofructokinase activity Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tagatose-6-phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 313

313

Tagatose-6-phosphate kinase HAMAP MF_01557

PRO_0000203914

Secondary structure

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313

Helix Strand Turn

Details...

Beta strand

2 – 8

7

Beta strand

10 – 16

7

Beta strand

24 – 29

6

Beta strand

31 – 37

7

Helix

38 – 49

12

Beta strand

53 – 60

8

Helix

61 – 74

14

Beta strand

81 – 85

5

Beta strand

88 – 95

8

Beta strand

98 – 104

7

Helix

111 – 125

15

Beta strand

129 – 135

7

Helix

145 – 155

11

Beta strand

159 – 163

5

Helix

167 – 174

8

Beta strand

180 – 182

3

Helix

186 – 193

8

Helix

202 – 208

7

Helix

212 – 214

3

Beta strand

218 – 223

6

Helix

225 – 227

3

Beta strand

229 – 233

5

Beta strand

236 – 241

6

Helix

253 – 266

14

Helix

271 – 286

16

Helix

296 – 303

8

Beta strand

307 – 311

5

Sequences

	Sequence		Length	Mass (Da)
	Q833W9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 90029311154D7BD2	FASTA	313	33,817
	10 20 30 40 50 60 MIVTVTMNPS IDISYLLDHL KLDTVNRTSQ VTKTPGGKGL NVTRVIHDLG GDVIATGVLG 70 80 90 100 110 120 GFHGAFIANE LKKANIPQAF TSIKEETRDS IAILHEGNQT EILEAGPTVS PEEISNFLEN 130 140 150 160 170 180 FDQLIKQAEI VTISGSLAKG LPSDFYQELV QKAHAQEVKV LLDTSGDSLR QVLQGPWKPY 190 200 210 220 230 240 LIKPNLEELE GLLGQDFSEN PLAAVQTALT KPMFAGIEWI VISLGKDGAI AKHHDQFYRV 250 260 270 280 290 300 KIPTIQAKNP VGSGDATIAG LAYGLAKDAP AAELLKWGMA AGMANAQERM TGHVDVENVK 310 KHLMNIQVVE IAK

References

[1]

"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis." Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A. , Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M. Science 299:2071-2074(2003) [PubMed: 12663927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700802 / V583.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016830 Genomic DNA. Translation: AAO81574.1.

RefSeq

NP_815504.1. NC_004668.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AWD	X-ray	2.00	A/B	2-313	[»]
2F02	X-ray	1.90	A/B	2-313	[»]

ProteinModelPortal

Q833W9.

SMR

Q833W9. Positions 1-313.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1200692.

GenomeReviews

Gene locus EF_1806 in contig AE016830_GR.

KEGG

efa:EF1806.

NMPDR

fig|226185.1.peg.1689.

PATRIC

21853942. VBIEntFae7065_1697.

TIGR

EF_1806.

Phylogenomic databases

HOGENOM

HBG670529.

OMA

GAFIANE.

Enzyme and pathway databases

BioCyc

EFAE226185:EF_1806-MONOMER.

Family and domain databases

HAMAP

MF_01557. LacC.
[Tree]

InterPro

IPR022463. 1-phosphofructokinase.
IPR011611. Carb/pur_kinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR005926. LacC.
IPR017583. Tagatose/fructose_Pkinase.
[Graphical view]

KO

K00917.

Pfam

PF00294. PfkB. 1 hit.
[Graphical view]

PIRSF

PIRSF000535. 1PFK/6PFK/LacC. 1 hit.

TIGRFAMs

TIGR03168. 1-PFK. 1 hit.
TIGR03828. PfkB. 1 hit.

PROSITE

PS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

LACC_ENTFA

Accession

Primary (citable) accession number: Q833W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program