Q833W9 (LACC_ENTFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tagatose-6-phosphate kinase
EC=2.7.1.144

Alternative name(s):
Phosphotagatokinase

Gene names

Name:	lacC
Ordered Locus Names:	EF_1806

Organism

Enterococcus faecalis (strain ATCC 700802 / V583) [Reference proteome] [HAMAP]

Taxonomic identifier

226185 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Enterococcaceae › Enterococcus › Enterococcus faecalis

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate. HAMAP-Rule MF_01557
Pathway	Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2. HAMAP-Rule MF_01557
Sequence similarities	Belongs to the carbohydrate kinase PfkB family. LacC subfamily.

Ontologies

Keywords
Biological process	Lactose metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-tagatose 6-phosphate catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tagatose-6-phosphate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 313

313

Tagatose-6-phosphate kinase HAMAP-Rule MF_01557

PRO_0000203914

Secondary structure

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313

Helix Strand Turn

Details...

Beta strand

2 – 8

7

Beta strand

10 – 16

7

Beta strand

24 – 29

6

Beta strand

31 – 37

7

Helix

38 – 49

12

Beta strand

53 – 60

8

Helix

61 – 73

13

Beta strand

81 – 85

5

Beta strand

88 – 95

8

Beta strand

98 – 104

7

Helix

111 – 125

15

Beta strand

129 – 135

7

Helix

145 – 155

11

Beta strand

159 – 163

5

Helix

167 – 174

8

Beta strand

180 – 182

3

Helix

186 – 193

8

Helix

202 – 209

8

Helix

212 – 214

3

Beta strand

218 – 223

6

Helix

225 – 227

3

Beta strand

229 – 233

5

Beta strand

236 – 241

6

Helix

253 – 266

14

Helix

271 – 287

17

Beta strand

288 – 292

5

Helix

296 – 303

8

Beta strand

307 – 310

4

Sequences

	Sequence		Length	Mass (Da)
	Q833W9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 90029311154D7BD2	FASTA	313	33,817
	10 20 30 40 50 60 MIVTVTMNPS IDISYLLDHL KLDTVNRTSQ VTKTPGGKGL NVTRVIHDLG GDVIATGVLG 70 80 90 100 110 120 GFHGAFIANE LKKANIPQAF TSIKEETRDS IAILHEGNQT EILEAGPTVS PEEISNFLEN 130 140 150 160 170 180 FDQLIKQAEI VTISGSLAKG LPSDFYQELV QKAHAQEVKV LLDTSGDSLR QVLQGPWKPY 190 200 210 220 230 240 LIKPNLEELE GLLGQDFSEN PLAAVQTALT KPMFAGIEWI VISLGKDGAI AKHHDQFYRV 250 260 270 280 290 300 KIPTIQAKNP VGSGDATIAG LAYGLAKDAP AAELLKWGMA AGMANAQERM TGHVDVENVK 310 KHLMNIQVVE IAK

References

[1]

"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis." Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A. , Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M. Science 299:2071-2074(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700802 / V583.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016830 Genomic DNA. Translation: AAO81574.1.

RefSeq

NP_815504.1. NC_004668.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AWD	X-ray	2.00	A/B	2-313	[»]
2F02	X-ray	1.90	A/B	2-313	[»]

ProteinModelPortal

Q833W9.

SMR

Q833W9. Positions 1-313.

ModBase

Search...

Protein-protein interaction databases

STRING

226185.EF1806.

Protocols and materials databases

DNASU

1200692.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAO81574; AAO81574; EF_1806.

GeneID

1200692.

KEGG

efa:EF1806.

PATRIC

21853942. VBIEntFae7065_1697.

Phylogenomic databases

eggNOG

COG1105.

KO

K00917.

OMA

ANAQERM.

Enzyme and pathway databases

BioCyc

EFAE226185:GHI1-1877-MONOMER.

UniPathway

UPA00704; UER00715.

Family and domain databases

Gene3D

2.20.150.10. 1 hit.

HAMAP

MF_01557. LacC.

InterPro

IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR005926. LacC.
IPR011611. PfkB_dom.
IPR023314. Put_2deH3deoxyglucokinase_N.
IPR017583. Tagatose/fructose_Pkinase.
[Graphical view]

Pfam

PF00294. PfkB. 1 hit.
[Graphical view]

PIRSF

PIRSF000535. 1PFK/6PFK/LacC. 1 hit.

TIGRFAMs

TIGR03168. 1-PFK. 1 hit.

PROSITE

PS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q833W9.

Entry information

Entry name

LACC_ENTFA

Accession

Primary (citable) accession number: Q833W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program