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Protein

Tagatose-6-phosphate kinase

Gene

lacC

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate.UniRule annotation

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (fruK-2), Tagatose-6-phosphate kinase (fruK-1), Tagatose-6-phosphate kinase (lacC)
  2. Tagatose 1,6-diphosphate aldolase 1 (lacD1), Tagatose 1,6-diphosphate aldolase 2 (lacD2)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lactose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00704; UER00715.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose-6-phosphate kinaseUniRule annotation (EC:2.7.1.144UniRule annotation)
Alternative name(s):
PhosphotagatokinaseUniRule annotation
Gene namesi
Name:lacCUniRule annotation
Ordered Locus Names:EF_1806
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002039141 – 313Tagatose-6-phosphate kinaseAdd BLAST313

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1806.

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Beta strandi10 – 16Combined sources7
Beta strandi24 – 29Combined sources6
Beta strandi31 – 37Combined sources7
Helixi38 – 49Combined sources12
Beta strandi53 – 60Combined sources8
Helixi61 – 73Combined sources13
Beta strandi81 – 85Combined sources5
Beta strandi88 – 95Combined sources8
Beta strandi98 – 104Combined sources7
Helixi111 – 125Combined sources15
Beta strandi129 – 135Combined sources7
Helixi145 – 155Combined sources11
Beta strandi159 – 163Combined sources5
Helixi167 – 174Combined sources8
Beta strandi180 – 182Combined sources3
Helixi186 – 193Combined sources8
Helixi202 – 209Combined sources8
Helixi212 – 214Combined sources3
Beta strandi218 – 223Combined sources6
Helixi225 – 227Combined sources3
Beta strandi229 – 233Combined sources5
Beta strandi236 – 241Combined sources6
Helixi253 – 266Combined sources14
Helixi271 – 287Combined sources17
Beta strandi288 – 292Combined sources5
Helixi296 – 303Combined sources8
Beta strandi307 – 310Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AWDX-ray2.00A/B2-313[»]
2F02X-ray1.90A/B2-313[»]
ProteinModelPortaliQ833W9.
SMRiQ833W9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ833W9.

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family. LacC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DE4. Bacteria.
COG1105. LUCA.
KOiK00917.
OMAiANAQERM.

Family and domain databases

CDDicd01164. FruK_PfkB_like. 1 hit.
Gene3Di2.20.150.10. 1 hit.
3.40.1190.20. 1 hit.
HAMAPiMF_01557. LacC. 1 hit.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR005926. LacC.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
IPR023314. T6P/1PhK_N_dom.
IPR017583. Tagatose/fructose_Pkinase.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PIRSFiPIRSF000535. 1PFK/6PFK/LacC. 1 hit.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR03168. 1-PFK. 1 hit.
PROSITEiPS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q833W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVTVTMNPS IDISYLLDHL KLDTVNRTSQ VTKTPGGKGL NVTRVIHDLG
60 70 80 90 100
GDVIATGVLG GFHGAFIANE LKKANIPQAF TSIKEETRDS IAILHEGNQT
110 120 130 140 150
EILEAGPTVS PEEISNFLEN FDQLIKQAEI VTISGSLAKG LPSDFYQELV
160 170 180 190 200
QKAHAQEVKV LLDTSGDSLR QVLQGPWKPY LIKPNLEELE GLLGQDFSEN
210 220 230 240 250
PLAAVQTALT KPMFAGIEWI VISLGKDGAI AKHHDQFYRV KIPTIQAKNP
260 270 280 290 300
VGSGDATIAG LAYGLAKDAP AAELLKWGMA AGMANAQERM TGHVDVENVK
310
KHLMNIQVVE IAK
Length:313
Mass (Da):33,817
Last modified:June 1, 2003 - v1
Checksum:i90029311154D7BD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO81574.1.
RefSeqiNP_815504.1. NC_004668.1.
WP_010706669.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO81574; AAO81574; EF_1806.
GeneIDi1200692.
KEGGiefa:EF1806.
PATRICi21853942. VBIEntFae7065_1697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO81574.1.
RefSeqiNP_815504.1. NC_004668.1.
WP_010706669.1. NC_004668.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AWDX-ray2.00A/B2-313[»]
2F02X-ray1.90A/B2-313[»]
ProteinModelPortaliQ833W9.
SMRiQ833W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF1806.

Protocols and materials databases

DNASUi1200692.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO81574; AAO81574; EF_1806.
GeneIDi1200692.
KEGGiefa:EF1806.
PATRICi21853942. VBIEntFae7065_1697.

Phylogenomic databases

eggNOGiENOG4105DE4. Bacteria.
COG1105. LUCA.
KOiK00917.
OMAiANAQERM.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00715.

Miscellaneous databases

EvolutionaryTraceiQ833W9.

Family and domain databases

CDDicd01164. FruK_PfkB_like. 1 hit.
Gene3Di2.20.150.10. 1 hit.
3.40.1190.20. 1 hit.
HAMAPiMF_01557. LacC. 1 hit.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR005926. LacC.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
IPR023314. T6P/1PhK_N_dom.
IPR017583. Tagatose/fructose_Pkinase.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PIRSFiPIRSF000535. 1PFK/6PFK/LacC. 1 hit.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR03168. 1-PFK. 1 hit.
PROSITEiPS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLACC_ENTFA
AccessioniPrimary (citable) accession number: Q833W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.