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Protein

Tagatose-6-phosphate kinase

Gene

lacC

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate.UniRule annotation

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (fruK-2), Tagatose-6-phosphate kinase (fruK-1), Tagatose-6-phosphate kinase (lacC)
  2. Tagatose 1,6-diphosphate aldolase 1 (lacD1), Tagatose 1,6-diphosphate aldolase 2 (lacD2)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lactose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1778-MONOMER.
UniPathwayiUPA00704; UER00715.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose-6-phosphate kinaseUniRule annotation (EC:2.7.1.144UniRule annotation)
Alternative name(s):
PhosphotagatokinaseUniRule annotation
Gene namesi
Name:lacCUniRule annotation
Ordered Locus Names:EF_1806
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Tagatose-6-phosphate kinasePRO_0000203914Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226185.EF1806.

Structurei

Secondary structure

1
313
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Beta strandi10 – 167Combined sources
Beta strandi24 – 296Combined sources
Beta strandi31 – 377Combined sources
Helixi38 – 4912Combined sources
Beta strandi53 – 608Combined sources
Helixi61 – 7313Combined sources
Beta strandi81 – 855Combined sources
Beta strandi88 – 958Combined sources
Beta strandi98 – 1047Combined sources
Helixi111 – 12515Combined sources
Beta strandi129 – 1357Combined sources
Helixi145 – 15511Combined sources
Beta strandi159 – 1635Combined sources
Helixi167 – 1748Combined sources
Beta strandi180 – 1823Combined sources
Helixi186 – 1938Combined sources
Helixi202 – 2098Combined sources
Helixi212 – 2143Combined sources
Beta strandi218 – 2236Combined sources
Helixi225 – 2273Combined sources
Beta strandi229 – 2335Combined sources
Beta strandi236 – 2416Combined sources
Helixi253 – 26614Combined sources
Helixi271 – 28717Combined sources
Beta strandi288 – 2925Combined sources
Helixi296 – 3038Combined sources
Beta strandi307 – 3104Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AWDX-ray2.00A/B2-313[»]
2F02X-ray1.90A/B2-313[»]
ProteinModelPortaliQ833W9.
SMRiQ833W9. Positions 1-313.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ833W9.

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family. LacC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DE4. Bacteria.
COG1105. LUCA.
KOiK00917.
OMAiANAQERM.
OrthoDBiEOG61KBKF.

Family and domain databases

Gene3Di2.20.150.10. 1 hit.
3.40.1190.20. 1 hit.
HAMAPiMF_01557. LacC.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR005926. LacC.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
IPR023314. T6P/1PhK_N_dom.
IPR017583. Tagatose/fructose_Pkinase.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PIRSFiPIRSF000535. 1PFK/6PFK/LacC. 1 hit.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR03168. 1-PFK. 1 hit.
PROSITEiPS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q833W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVTVTMNPS IDISYLLDHL KLDTVNRTSQ VTKTPGGKGL NVTRVIHDLG
60 70 80 90 100
GDVIATGVLG GFHGAFIANE LKKANIPQAF TSIKEETRDS IAILHEGNQT
110 120 130 140 150
EILEAGPTVS PEEISNFLEN FDQLIKQAEI VTISGSLAKG LPSDFYQELV
160 170 180 190 200
QKAHAQEVKV LLDTSGDSLR QVLQGPWKPY LIKPNLEELE GLLGQDFSEN
210 220 230 240 250
PLAAVQTALT KPMFAGIEWI VISLGKDGAI AKHHDQFYRV KIPTIQAKNP
260 270 280 290 300
VGSGDATIAG LAYGLAKDAP AAELLKWGMA AGMANAQERM TGHVDVENVK
310
KHLMNIQVVE IAK
Length:313
Mass (Da):33,817
Last modified:June 1, 2003 - v1
Checksum:i90029311154D7BD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO81574.1.
RefSeqiNP_815504.1. NC_004668.1.
WP_010706669.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO81574; AAO81574; EF_1806.
GeneIDi1200692.
KEGGiefa:EF1806.
PATRICi21853942. VBIEntFae7065_1697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO81574.1.
RefSeqiNP_815504.1. NC_004668.1.
WP_010706669.1. NC_004668.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AWDX-ray2.00A/B2-313[»]
2F02X-ray1.90A/B2-313[»]
ProteinModelPortaliQ833W9.
SMRiQ833W9. Positions 1-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF1806.

Protocols and materials databases

DNASUi1200692.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO81574; AAO81574; EF_1806.
GeneIDi1200692.
KEGGiefa:EF1806.
PATRICi21853942. VBIEntFae7065_1697.

Phylogenomic databases

eggNOGiENOG4105DE4. Bacteria.
COG1105. LUCA.
KOiK00917.
OMAiANAQERM.
OrthoDBiEOG61KBKF.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00715.
BioCyciEFAE226185:GHI1-1778-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ833W9.

Family and domain databases

Gene3Di2.20.150.10. 1 hit.
3.40.1190.20. 1 hit.
HAMAPiMF_01557. LacC.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR005926. LacC.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
IPR023314. T6P/1PhK_N_dom.
IPR017583. Tagatose/fructose_Pkinase.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PIRSFiPIRSF000535. 1PFK/6PFK/LacC. 1 hit.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR03168. 1-PFK. 1 hit.
PROSITEiPS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiLACC_ENTFA
AccessioniPrimary (citable) accession number: Q833W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: November 11, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.