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Q833G5 (HEMH_ENTFA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:EF_1989
OrganismEnterococcus faecalis (Streptococcus faecalis)
Taxonomic identifier1351 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Enterococcaceae › Enterococcus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Ferrochelatase HAMAP MF_00323
PRO_0000175141

Sites

Metal binding1911Iron By similarity
Metal binding2701Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q833G5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: CED87CB533F02D0E

FASTA31336,050
        10         20         30         40         50         60 
MKRTGILLVN LGTPKDSSKT EVRKYLKTFL SDRRVIKIHP IIWKPILNGI ILNIRPKKSA 

        70         80         90        100        110        120 
KLYQKICTEN GFPLLEYTEK QMENLKNICP EVEVTIGMSY SEPSIETALD TLLSKEIEEL 

       130        140        150        160        170        180 
NVIPMYPQYS GTTVGSVFDS VMNYFIKSDR IVDIKFIRSF YNNPQYIDYF SKKINEALNE 

       190        200        210        220        230        240 
SPIDAIVFSY HGIPMSYVKD GDNYPKECTK TTKLIMDKLG DIRYYQTYQS KFGPSEWLKP 

       250        260        270        280        290        300 
ATDDTLKKLP SKGIKNILIV APGFVVDCLE TIEELEHENR NYFLENGGEV YKYVHPFNGD 

       310 
IEFAKLVKDI ISL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016830 Genomic DNA. Translation: AAO81734.1.
RefSeqNP_815664.1. NC_004668.1.

3D structure databases

ProteinModelPortalQ833G5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1200865.
GenomeReviewsGene locus EF_1989 in contig AE016830_GR.
KEGGefa:EF1989.
NMPDRfig|226185.1.peg.1849.
PATRIC21854278. VBIEntFae7065_1865.
TIGREF_1989.

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.

Enzyme and pathway databases

BioCycEFAE226185:EF_1989-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_ENTFA
AccessionPrimary (citable) accession number: Q833G5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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