Q831R1 (UPPP1_ENTFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	EF_2439

Organism

Enterococcus faecalis (Streptococcus faecalis)

Taxonomic identifier

1351 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Enterococcaceae › Enterococcus

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Undecaprenyl-diphosphatase HAMAP MF_01006		PRO_0000151149
Regions
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	150 – 170	21	Helical; Potential
	Transmembrane	188 – 208	21	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	255 – 275	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q831R1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 29C5E1746DCB1862	FASTA	276	30,819
	10 20 30 40 50 60 MLFANLWKAI ILGIIEGITE WLPISSTGHL ILVDEFIKLD LSKDFMEMFN VVIQLGAIMA 70 80 90 100 110 120 VVILYFHKLN PFSPKKNGEE KKDTWILWSK VLVACLPAAV IGLKFDDYLD AHFYNFLTVS 130 140 150 160 170 180 IMLIVYGIAF IIIEKRNKNV APKCTNLKDF TYKAALIVGA FQVLALIPGT SRSGATILGA 190 200 210 220 230 240 ILIGASRFVA TEFSFFLGIP VMFGASFLKI FKFLAKGNTF GSEEIIILIT GSIVAFVVSI 250 260 270 IAIKFLLNYL KKNDFTVFGW YRVILGAILI GYWLFS

References

[1]

"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis." Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A. , Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M. Science 299:2071-2074(2003) [PubMed: 12663927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700802 / V583.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016830 Genomic DNA. Translation: AAO82157.1.
RefSeq	NP_816087.1. NC_004668.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1201305.
GenomeReviews	Gene locus EF_2439 in contig AE016830_GR.
KEGG	efa:EF2439.
NMPDR	fig|226185.1.peg.2272.
PATRIC	21855113. VBIEntFae7065_2277.
TIGR	EF_2439.
Phylogenomic databases
HOGENOM	HBG391969.
OMA	QLWAKVI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	EFAE226185:EF_2439-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. Undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_ENTFA

Accession

Primary (citable) accession number: Q831R1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program