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Q831R1

- UPPP1_ENTFA

UniProt

Q831R1 - UPPP1_ENTFA

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.By similarity

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciEFAE226185:GHI1-2389-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase (EC:3.6.1.27)
    Alternative name(s):
    Bacitracin resistance protein
    Undecaprenyl pyrophosphate phosphatase
    Gene namesi
    Name:uppP
    Synonyms:bacA, upk
    Ordered Locus Names:EF_2439
    OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
    Taxonomic identifieri226185 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
    ProteomesiUP000001415: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatasePRO_0000151149Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226185.EF2439.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    KOiK06153.
    OMAiMEQINIG.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q831R1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFANLWKAI ILGIIEGITE WLPISSTGHL ILVDEFIKLD LSKDFMEMFN    50
    VVIQLGAIMA VVILYFHKLN PFSPKKNGEE KKDTWILWSK VLVACLPAAV 100
    IGLKFDDYLD AHFYNFLTVS IMLIVYGIAF IIIEKRNKNV APKCTNLKDF 150
    TYKAALIVGA FQVLALIPGT SRSGATILGA ILIGASRFVA TEFSFFLGIP 200
    VMFGASFLKI FKFLAKGNTF GSEEIIILIT GSIVAFVVSI IAIKFLLNYL 250
    KKNDFTVFGW YRVILGAILI GYWLFS 276
    Length:276
    Mass (Da):30,819
    Last modified:June 1, 2003 - v1
    Checksum:i29C5E1746DCB1862
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO82157.1.
    RefSeqiNP_816087.1. NC_004668.1.

    Genome annotation databases

    EnsemblBacteriaiAAO82157; AAO82157; EF_2439.
    GeneIDi1201305.
    KEGGiefa:EF2439.
    PATRICi21855113. VBIEntFae7065_2277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO82157.1 .
    RefSeqi NP_816087.1. NC_004668.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226185.EF2439.

    Protocols and materials databases

    DNASUi 1201305.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO82157 ; AAO82157 ; EF_2439 .
    GeneIDi 1201305.
    KEGGi efa:EF2439.
    PATRICi 21855113. VBIEntFae7065_2277.

    Phylogenomic databases

    eggNOGi COG1968.
    KOi K06153.
    OMAi MEQINIG.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci EFAE226185:GHI1-2389-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700802 / V583.

    Entry informationi

    Entry nameiUPPP1_ENTFA
    AccessioniPrimary (citable) accession number: Q831R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3