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Q831R1

- UPPP1_ENTFA

UniProt

Q831R1 - UPPP1_ENTFA

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity).By similarity

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-2389-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:EF_2439
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Undecaprenyl-diphosphatasePRO_0000151149Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226185.EF2439.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiMEQINIG.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q831R1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFANLWKAI ILGIIEGITE WLPISSTGHL ILVDEFIKLD LSKDFMEMFN
60 70 80 90 100
VVIQLGAIMA VVILYFHKLN PFSPKKNGEE KKDTWILWSK VLVACLPAAV
110 120 130 140 150
IGLKFDDYLD AHFYNFLTVS IMLIVYGIAF IIIEKRNKNV APKCTNLKDF
160 170 180 190 200
TYKAALIVGA FQVLALIPGT SRSGATILGA ILIGASRFVA TEFSFFLGIP
210 220 230 240 250
VMFGASFLKI FKFLAKGNTF GSEEIIILIT GSIVAFVVSI IAIKFLLNYL
260 270
KKNDFTVFGW YRVILGAILI GYWLFS
Length:276
Mass (Da):30,819
Last modified:June 1, 2003 - v1
Checksum:i29C5E1746DCB1862
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO82157.1.
RefSeqiNP_816087.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO82157; AAO82157; EF_2439.
GeneIDi1201305.
KEGGiefa:EF2439.
PATRICi21855113. VBIEntFae7065_2277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO82157.1 .
RefSeqi NP_816087.1. NC_004668.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF2439.

Protocols and materials databases

DNASUi 1201305.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO82157 ; AAO82157 ; EF_2439 .
GeneIDi 1201305.
KEGGi efa:EF2439.
PATRICi 21855113. VBIEntFae7065_2277.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi MEQINIG.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci EFAE226185:GHI1-2389-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiUPPP1_ENTFA
AccessioniPrimary (citable) accession number: Q831R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3