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Protein

Methionine import ATP-binding protein MetN 2

Gene

metN2

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-2446-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine import ATP-binding protein MetN 2UniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:metN2UniRule annotation
Ordered Locus Names:EF_2498
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Methionine import ATP-binding protein MetN 2PRO_0000270293Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).UniRule annotation

Protein-protein interaction databases

STRINGi226185.EF2498.

Structurei

Secondary structure

1
345
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi258 – 2647Combined sources
Beta strandi267 – 27711Combined sources
Helixi284 – 2929Combined sources
Beta strandi295 – 30612Combined sources
Beta strandi309 – 32012Combined sources
Helixi322 – 33413Combined sources
Beta strandi338 – 3436Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QSWX-ray1.50A249-345[»]
ProteinModelPortaliQ831K6.
SMRiQ831K6. Positions 256-345.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ831K6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 243240ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEI. Bacteria.
COG1135. LUCA.
KOiK02071.
OMAiQRQKMIQ.
OrthoDBiEOG6T7N3V.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF186. PTHR24220:SF186. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q831K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIELRHVK KEFSGKAGKV TALKDIDLTV ESGDIYGIIG YSGAGKSTLV
60 70 80 90 100
RLLNGLETPT EGEVEIQGQD IALLPNKELR NFRKKIGMIF QHFNLLWSRT
110 120 130 140 150
VLENIMLPLE IAGVPKQNRK SRAEELIKLV GLEGRETAYP SQLSGGQKQR
160 170 180 190 200
VGIARALANN PDILLCDEAT SALDPQTTDE VLELLLKINQ ELNLTVVLIT
210 220 230 240 250
HEMHVIRKIC NRVAVMEYGE IVEEGKVIDI FKKPQTEIAK RFIQQEADKN
260 270 280 290 300
IEETELVVEE MLEQYPNGKI VRLLFHGEQA KLPIISHIVQ EYQVEVSIIQ
310 320 330 340
GNIQQTKQGA VGSLYIQLLG EEQNILAAIE GLRKLRVETE VIGNE
Length:345
Mass (Da):38,615
Last modified:June 1, 2003 - v1
Checksum:i4194CF9C5DD2C489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82214.1.
RefSeqiNP_816144.1. NC_004668.1.
WP_002356639.1. NZ_KE136528.1.

Genome annotation databases

EnsemblBacteriaiAAO82214; AAO82214; EF_2498.
GeneIDi1201362.
KEGGiefa:EF2498.
PATRICi21855229. VBIEntFae7065_2335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82214.1.
RefSeqiNP_816144.1. NC_004668.1.
WP_002356639.1. NZ_KE136528.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QSWX-ray1.50A249-345[»]
ProteinModelPortaliQ831K6.
SMRiQ831K6. Positions 256-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF2498.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO82214; AAO82214; EF_2498.
GeneIDi1201362.
KEGGiefa:EF2498.
PATRICi21855229. VBIEntFae7065_2335.

Phylogenomic databases

eggNOGiENOG4108JEI. Bacteria.
COG1135. LUCA.
KOiK02071.
OMAiQRQKMIQ.
OrthoDBiEOG6T7N3V.

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-2446-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ831K6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF186. PTHR24220:SF186. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiMETN2_ENTFA
AccessioniPrimary (citable) accession number: Q831K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: November 11, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.