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Q831F5 (KITH_ENTFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:EF_2555
OrganismEnterococcus faecalis (strain ATCC 700802 / V583) [Reference proteome] [HAMAP]
Taxonomic identifier226185 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Thymidine kinase HAMAP-Rule MF_00124
PRO_0000174974

Regions

Nucleotide binding9 – 168ATP By similarity
Nucleotide binding85 – 884ATP By similarity

Sites

Active site861Proton acceptor Potential
Metal binding1431Zinc By similarity
Metal binding1461Zinc By similarity
Metal binding1801Zinc By similarity
Metal binding1831Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q831F5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 9EC53A18C39A6C3C

FASTA19422,452
        10         20         30         40         50         60 
MAQLFFKYGA MNSGKTIEIL KVAHNYEEQD KPVVLMTSGL DTRDGVGKVS SRIGLRRDAI 

        70         80         90        100        110        120 
PIFEETNVFD LINDLSYKPF CVLVDECQFL NKHHVIEFAR IVDELDIPVM AFGLKNDFRN 

       130        140        150        160        170        180 
ELFEGSKYLL LYADKLEELK TICWFCHKKA TMNLHYIDGN PVYEGDQVQI GGNEAYYPVC 

       190 
RKHYFHPKTV NEEQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016830 Genomic DNA. Translation: AAO82267.1.
RefSeqNP_816197.1. NC_004668.1.

3D structure databases

ProteinModelPortalQ831F5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226185.EF2555.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO82267; AAO82267; EF_2555.
GeneID1201417.
KEGGefa:EF2555.
PATRIC21855337. VBIEntFae7065_2388.

Phylogenomic databases

eggNOGCOG1435.
KOK00857.
OMADEITAYI.
OrthoDBEOG69D3J2.

Enzyme and pathway databases

BioCycEFAE226185:GHI1-2501-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_ENTFA
AccessionPrimary (citable) accession number: Q831F5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families