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Q831F5

- KITH_ENTFA

UniProt

Q831F5 - KITH_ENTFA

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Protein
Thymidine kinase
Gene
tdk, EF_2555
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor Reviewed prediction
Metal bindingi143 – 1431Zinc By similarity
Metal bindingi146 – 1461Zinc By similarity
Metal bindingi180 – 1801Zinc By similarity
Metal bindingi183 – 1831Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarity
Nucleotide bindingi85 – 884ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-2501-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:EF_2555
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Thymidine kinaseUniRule annotation
PRO_0000174974Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226185.EF2555.

Structurei

3D structure databases

ProteinModelPortaliQ831F5.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
KOiK00857.
OMAiDEITAYI.
OrthoDBiEOG69D3J2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q831F5-1 [UniParc]FASTAAdd to Basket

« Hide

MAQLFFKYGA MNSGKTIEIL KVAHNYEEQD KPVVLMTSGL DTRDGVGKVS    50
SRIGLRRDAI PIFEETNVFD LINDLSYKPF CVLVDECQFL NKHHVIEFAR 100
IVDELDIPVM AFGLKNDFRN ELFEGSKYLL LYADKLEELK TICWFCHKKA 150
TMNLHYIDGN PVYEGDQVQI GGNEAYYPVC RKHYFHPKTV NEEQ 194
Length:194
Mass (Da):22,452
Last modified:June 1, 2003 - v1
Checksum:i9EC53A18C39A6C3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO82267.1.
RefSeqiNP_816197.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO82267; AAO82267; EF_2555.
GeneIDi1201417.
KEGGiefa:EF2555.
PATRICi21855337. VBIEntFae7065_2388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO82267.1 .
RefSeqi NP_816197.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q831F5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226185.EF2555.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO82267 ; AAO82267 ; EF_2555 .
GeneIDi 1201417.
KEGGi efa:EF2555.
PATRICi 21855337. VBIEntFae7065_2388.

Phylogenomic databases

eggNOGi COG1435.
KOi K00857.
OMAi DEITAYI.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci EFAE226185:GHI1-2501-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiKITH_ENTFA
AccessioniPrimary (citable) accession number: Q831F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi