Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Magnesium transporter MgtE

Gene

mgtE

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a magnesium transporter.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Magnesium 1By similarity
Metal bindingi102 – 1021Magnesium 2By similarity
Metal bindingi218 – 2181Magnesium 3By similarity
Metal bindingi220 – 2201Magnesium 4By similarity
Metal bindingi230 – 2301Magnesium 5By similarity
Metal bindingi251 – 2511Magnesium 1By similarity
Metal bindingi259 – 2591Magnesium 3By similarity
Metal bindingi263 – 2631Magnesium 4By similarity
Metal bindingi420 – 4201Magnesium 4By similarity
Metal bindingi434 – 4341Magnesium 6By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-2609-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter MgtE
Gene namesi
Name:mgtE
Ordered Locus Names:EF_2668
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 278278CytoplasmicBy similarityAdd
BLAST
Transmembranei279 – 30628Helical; Name=1By similarityAdd
BLAST
Intramembranei307 – 32115By similarityAdd
BLAST
Transmembranei322 – 34524Helical; Name=2By similarityAdd
BLAST
Topological domaini346 – 3527CytoplasmicBy similarity
Transmembranei353 – 38331Helical; Name=3By similarityAdd
BLAST
Intramembranei384 – 3874By similarity
Transmembranei388 – 41629Helical; Name=4By similarityAdd
BLAST
Intramembranei417 – 42610By similarity
Transmembranei427 – 44923Helical; Name=5By similarityAdd
BLAST
Topological domaini450 – 4523PeriplasmicBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Magnesium transporter MgtEPRO_0000363888Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi226185.EF2668.

Structurei

Secondary structure

1
453
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 1913Combined sources
Helixi23 – 308Combined sources
Helixi35 – 428Combined sources
Helixi47 – 5610Combined sources
Helixi59 – 668Combined sources
Beta strandi73 – 753Combined sources
Helixi78 – 825Combined sources
Helixi85 – 928Combined sources
Helixi97 – 10610Combined sources
Helixi109 – 1179Combined sources
Helixi121 – 13010Combined sources
Helixi138 – 1414Combined sources
Beta strandi151 – 1544Combined sources
Helixi155 – 16511Combined sources
Beta strandi173 – 1786Combined sources
Beta strandi183 – 1897Combined sources
Helixi190 – 1934Combined sources
Helixi202 – 2054Combined sources
Beta strandi206 – 2083Combined sources
Helixi219 – 22911Combined sources
Beta strandi232 – 2376Combined sources
Beta strandi242 – 2487Combined sources
Helixi249 – 26113Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OUXX-ray2.16A/B2-285[»]
ProteinModelPortaliQ830V1.
SMRiQ830V1. Positions 6-262.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ830V1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 20564CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini206 – 26257CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJW. Bacteria.
COG2239. LUCA.
KOiK06213.
OMAiRAIQRYD.
OrthoDBiEOG60GRRN.

Family and domain databases

Gene3Di1.10.357.20. 1 hit.
InterProiIPR000644. CBS_dom.
IPR006668. Mg_transptr_MgtE_intracell_dom.
IPR006669. MgtE_transporter.
IPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01769. MgtE. 1 hit.
PF03448. MgtE_N. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM00924. MgtE_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00400. mgtE. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q830V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEGQEMEEQ FALLLETLKN QQMNEFRELF LALHIYEQGQ FYQSLDEKDR
60 70 80 90 100
QHLYNYLSPK ELADMFDVIE EDNENMKDYL AEMRPSYAAD MLAEMYTDNA
110 120 130 140 150
VDLLNMLDKS QKAKYLSLLS SEEAGEIKEL LHYEDETAGA IMTTEFVSIV
160 170 180 190 200
ANQTVRSAMY VLKNQADMAE TIYYVYVVDQ ENHLVGVISL RDLIVNDDDT
210 220 230 240 250
LIADILNERV ISVHVGDDQE DVAQTIRDYD FLAVPVTDYD DHLLGIVTVD
260 270 280 290 300
DIIDVIDDEA ASDYSGLAGV DVEEVSENPL KAASKRLPWL ITLLFLGMST
310 320 330 340 350
ASLISNYESL VSEASILAVF ISLITGTAGN AGTQSLAVAV RRLAMKDEKD
360 370 380 390 400
SNFGRLILSE VLTGLVTGAV TGLTIMIVVG VWQHNLPLGF VIGMAMLCAI
410 420 430 440 450
TVANLAGSLI PMLMDKLGFD PAVASGPFIT TLSDLTSVLI YFNIASMFMR

YFV
Length:453
Mass (Da):50,320
Last modified:June 1, 2003 - v1
Checksum:iCDB202115B7BD54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82375.1.
RefSeqiNP_816305.1. NC_004668.1.
WP_002362548.1. NZ_KE136528.1.

Genome annotation databases

EnsemblBacteriaiAAO82375; AAO82375; EF_2668.
GeneIDi1201525.
KEGGiefa:EF2668.
PATRICi21855539. VBIEntFae7065_2489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82375.1.
RefSeqiNP_816305.1. NC_004668.1.
WP_002362548.1. NZ_KE136528.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OUXX-ray2.16A/B2-285[»]
ProteinModelPortaliQ830V1.
SMRiQ830V1. Positions 6-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF2668.

Protocols and materials databases

DNASUi1201525.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO82375; AAO82375; EF_2668.
GeneIDi1201525.
KEGGiefa:EF2668.
PATRICi21855539. VBIEntFae7065_2489.

Phylogenomic databases

eggNOGiENOG4105CJW. Bacteria.
COG2239. LUCA.
KOiK06213.
OMAiRAIQRYD.
OrthoDBiEOG60GRRN.

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-2609-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ830V1.

Family and domain databases

Gene3Di1.10.357.20. 1 hit.
InterProiIPR000644. CBS_dom.
IPR006668. Mg_transptr_MgtE_intracell_dom.
IPR006669. MgtE_transporter.
IPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01769. MgtE. 1 hit.
PF03448. MgtE_N. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM00924. MgtE_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00400. mgtE. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.
  2. "Crystallization and preliminary X-ray diffraction analysis of the full-length Mg2+ transporter MgtE."
    Hattori M., Tanaka Y., Fukai S., Ishitani R., Nureki O.
    Acta Crystallogr. F 63:682-684(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.16 ANGSTROMS) OF 2-285.

Entry informationi

Entry nameiMGTE_ENTFA
AccessioniPrimary (citable) accession number: Q830V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 1, 2003
Last modified: December 9, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.