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Protein

Magnesium transporter MgtE

Gene

mgtE

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a magnesium transporter.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98Magnesium 1By similarity1
Metal bindingi102Magnesium 2By similarity1
Metal bindingi218Magnesium 3By similarity1
Metal bindingi220Magnesium 4By similarity1
Metal bindingi230Magnesium 5By similarity1
Metal bindingi251Magnesium 1By similarity1
Metal bindingi259Magnesium 3By similarity1
Metal bindingi263Magnesium 4By similarity1
Metal bindingi420Magnesium 4By similarity1
Metal bindingi434Magnesium 6By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter MgtE
Gene namesi
Name:mgtE
Ordered Locus Names:EF_2668
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 278CytoplasmicBy similarityAdd BLAST278
Transmembranei279 – 306Helical; Name=1By similarityAdd BLAST28
Intramembranei307 – 321By similarityAdd BLAST15
Transmembranei322 – 345Helical; Name=2By similarityAdd BLAST24
Topological domaini346 – 352CytoplasmicBy similarity7
Transmembranei353 – 383Helical; Name=3By similarityAdd BLAST31
Intramembranei384 – 387By similarity4
Transmembranei388 – 416Helical; Name=4By similarityAdd BLAST29
Intramembranei417 – 426By similarity10
Transmembranei427 – 449Helical; Name=5By similarityAdd BLAST23
Topological domaini450 – 452PeriplasmicBy similarity3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003638881 – 453Magnesium transporter MgtEAdd BLAST453

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi226185.EF2668.

Structurei

Secondary structure

1453
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 19Combined sources13
Helixi23 – 30Combined sources8
Helixi35 – 42Combined sources8
Helixi47 – 56Combined sources10
Helixi59 – 66Combined sources8
Beta strandi73 – 75Combined sources3
Helixi78 – 82Combined sources5
Helixi85 – 92Combined sources8
Helixi97 – 106Combined sources10
Helixi109 – 117Combined sources9
Helixi121 – 130Combined sources10
Helixi138 – 141Combined sources4
Beta strandi151 – 154Combined sources4
Helixi155 – 165Combined sources11
Beta strandi173 – 178Combined sources6
Beta strandi183 – 189Combined sources7
Helixi190 – 193Combined sources4
Helixi202 – 205Combined sources4
Beta strandi206 – 208Combined sources3
Helixi219 – 229Combined sources11
Beta strandi232 – 237Combined sources6
Beta strandi242 – 248Combined sources7
Helixi249 – 261Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OUXX-ray2.16A/B2-285[»]
ProteinModelPortaliQ830V1.
SMRiQ830V1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ830V1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 205CBS 1PROSITE-ProRule annotationAdd BLAST64
Domaini206 – 262CBS 2PROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJW. Bacteria.
COG2239. LUCA.
KOiK06213.
OMAiRAIQRYD.

Family and domain databases

Gene3Di1.10.357.20. 1 hit.
InterProiIPR000644. CBS_dom.
IPR006668. Mg_transptr_MgtE_intracell_dom.
IPR006669. MgtE_transporter.
IPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01769. MgtE. 1 hit.
PF03448. MgtE_N. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM00924. MgtE_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00400. mgtE. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q830V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEGQEMEEQ FALLLETLKN QQMNEFRELF LALHIYEQGQ FYQSLDEKDR
60 70 80 90 100
QHLYNYLSPK ELADMFDVIE EDNENMKDYL AEMRPSYAAD MLAEMYTDNA
110 120 130 140 150
VDLLNMLDKS QKAKYLSLLS SEEAGEIKEL LHYEDETAGA IMTTEFVSIV
160 170 180 190 200
ANQTVRSAMY VLKNQADMAE TIYYVYVVDQ ENHLVGVISL RDLIVNDDDT
210 220 230 240 250
LIADILNERV ISVHVGDDQE DVAQTIRDYD FLAVPVTDYD DHLLGIVTVD
260 270 280 290 300
DIIDVIDDEA ASDYSGLAGV DVEEVSENPL KAASKRLPWL ITLLFLGMST
310 320 330 340 350
ASLISNYESL VSEASILAVF ISLITGTAGN AGTQSLAVAV RRLAMKDEKD
360 370 380 390 400
SNFGRLILSE VLTGLVTGAV TGLTIMIVVG VWQHNLPLGF VIGMAMLCAI
410 420 430 440 450
TVANLAGSLI PMLMDKLGFD PAVASGPFIT TLSDLTSVLI YFNIASMFMR

YFV
Length:453
Mass (Da):50,320
Last modified:June 1, 2003 - v1
Checksum:iCDB202115B7BD54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82375.1.
RefSeqiNP_816305.1. NC_004668.1.
WP_002362548.1. NZ_KE136528.1.

Genome annotation databases

EnsemblBacteriaiAAO82375; AAO82375; EF_2668.
GeneIDi1201525.
KEGGiefa:EF2668.
PATRICi21855539. VBIEntFae7065_2489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82375.1.
RefSeqiNP_816305.1. NC_004668.1.
WP_002362548.1. NZ_KE136528.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OUXX-ray2.16A/B2-285[»]
ProteinModelPortaliQ830V1.
SMRiQ830V1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF2668.

Protocols and materials databases

DNASUi1201525.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO82375; AAO82375; EF_2668.
GeneIDi1201525.
KEGGiefa:EF2668.
PATRICi21855539. VBIEntFae7065_2489.

Phylogenomic databases

eggNOGiENOG4105CJW. Bacteria.
COG2239. LUCA.
KOiK06213.
OMAiRAIQRYD.

Miscellaneous databases

EvolutionaryTraceiQ830V1.

Family and domain databases

Gene3Di1.10.357.20. 1 hit.
InterProiIPR000644. CBS_dom.
IPR006668. Mg_transptr_MgtE_intracell_dom.
IPR006669. MgtE_transporter.
IPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01769. MgtE. 1 hit.
PF03448. MgtE_N. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM00924. MgtE_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00400. mgtE. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMGTE_ENTFA
AccessioniPrimary (citable) accession number: Q830V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.