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Q830V0

- NADK_ENTFA

UniProt

Q830V0 - NADK_ENTFA

Protein

NAD kinase

Gene

nadK

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorUniRule annotation
    Binding sitei148 – 1481NADUniRule annotation
    Binding sitei150 – 1501NADUniRule annotation
    Binding sitei185 – 1851NAD; via carbonyl oxygenUniRule annotation
    Binding sitei223 – 2231NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 462NADUniRule annotation
    Nucleotide bindingi122 – 1232NADUniRule annotation
    Nucleotide bindingi161 – 1666NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEFAE226185:GHI1-2611-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:EF_2670
    OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
    Taxonomic identifieri226185 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
    ProteomesiUP000001415: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265NAD kinasePRO_0000120619Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226185.EF2670.

    Structurei

    3D structure databases

    ProteinModelPortaliQ830V0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiIQMSEIA.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q830V0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVAIVHNSE EKSKQVTKQL TTLLEQNQIQ IDNRQPELVI SVGGDGTLLS    50
    AFHRFNHLLN EVSFLGVHTG HLGFYTDWRD YELKELVESL CIHREKSTSY 100
    PLLDVRIRFR DGKPDKHFLA LNESTIKRGN RTMVGDVFIK DELFERFRGD 150
    GLSISTPTGS TAYNKSIGGA VLHPSINAFQ LTEIASLNNR VFRTLGSPIV 200
    IAHTEWLEIK LQESDDYFVT VDQLDIYQEN IASVCYRIAD ERIHFASYRH 250
    MHFWHRVKDA FIGED 265
    Length:265
    Mass (Da):30,464
    Last modified:June 1, 2003 - v1
    Checksum:iE2C425FE6F36F5FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO82376.1.
    RefSeqiNP_816306.1. NC_004668.1.

    Genome annotation databases

    EnsemblBacteriaiAAO82376; AAO82376; EF_2670.
    GeneIDi1201527.
    KEGGiefa:EF2670.
    PATRICi21855543. VBIEntFae7065_2491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO82376.1 .
    RefSeqi NP_816306.1. NC_004668.1.

    3D structure databases

    ProteinModelPortali Q830V0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226185.EF2670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO82376 ; AAO82376 ; EF_2670 .
    GeneIDi 1201527.
    KEGGi efa:EF2670.
    PATRICi 21855543. VBIEntFae7065_2491.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi IQMSEIA.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci EFAE226185:GHI1-2611-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700802 / V583.

    Entry informationi

    Entry nameiNADK_ENTFA
    AccessioniPrimary (citable) accession number: Q830V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3