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Q830U2

- SYW_ENTFA

UniProt

Q830U2 - SYW_ENTFA

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Protein
Tryptophan--tRNA ligase
Gene
trpS, EF_2679
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei201 – 2011ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-2619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:EF_2679
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Tryptophan--tRNA ligaseUniRule annotation
PRO_0000136631Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226185.EF2679.

Structurei

3D structure databases

ProteinModelPortaliQ830U2.
SMRiQ830U2. Positions 1-333.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi10 – 189"HIGH" regionUniRule annotation
Motifi198 – 2025"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiDYDCFFC.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q830U2-1 [UniParc]FASTAAdd to Basket

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MKTIFSGIQP SGTPTIGNYI GAMKQFIELQ NEYNCYFCIV DEHAITVPQE    50
PQKLRQQIRS LAALYLAVGL DPQKATIFIQ SEVSAHAEAG WIIQCNTSIG 100
ELERMTQFKD KSQKNGRAGV SAGLLTYPPL MVGDIVLYNA DLVPVGDDQK 150
QHLELTRDFV ERFNKRYAQK NQEILTIPEV KIAEQGSRIM SLQEPTKKMS 200
KSDTNVKGFI SMLDEPAVIR KKIRSAVTDS TGVIEYNKEE KPGITNLLNI 250
YSAATGQTVE ELVQAYEGKG YGDFKADLAE AVVALLEPIQ VRYQELLASE 300
ELDMILDEGA ENARLVANKT LQRMKNAVGL GRKVRR 336
Length:336
Mass (Da):37,446
Last modified:June 1, 2003 - v1
Checksum:i67765FFCC966330A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO82384.1.
RefSeqiNP_816314.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO82384; AAO82384; EF_2679.
GeneIDi1201535.
KEGGiefa:EF2679.
PATRICi21855559. VBIEntFae7065_2499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016830 Genomic DNA. Translation: AAO82384.1 .
RefSeqi NP_816314.1. NC_004668.1.

3D structure databases

ProteinModelPortali Q830U2.
SMRi Q830U2. Positions 1-333.
ModBasei Search...

Protein-protein interaction databases

STRINGi 226185.EF2679.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO82384 ; AAO82384 ; EF_2679 .
GeneIDi 1201535.
KEGGi efa:EF2679.
PATRICi 21855559. VBIEntFae7065_2499.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi DYDCFFC.
OrthoDBi EOG686NJQ.

Enzyme and pathway databases

BioCyci EFAE226185:GHI1-2619-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiSYW_ENTFA
AccessioniPrimary (citable) accession number: Q830U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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