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Q82ZQ1

- ALLB_ENTFA

UniProt

Q82ZQ1 - ALLB_ENTFA

Protein

Allantoinase

Gene

allB

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi58 – 581Zinc 1UniRule annotation
    Metal bindingi60 – 601Zinc 1UniRule annotation
    Metal bindingi149 – 1491Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi149 – 1491Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi189 – 1891Zinc 2UniRule annotation
    Metal bindingi245 – 2451Zinc 2UniRule annotation
    Metal bindingi318 – 3181Zinc 1UniRule annotation

    GO - Molecular functioni

    1. allantoinase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: UniProtKB-HAMAP
    2. purine nucleobase metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciEFAE226185:GHI1-2930-MONOMER.
    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
    Alternative name(s):
    Allantoin-utilizing enzymeUniRule annotation
    Gene namesi
    Name:allBUniRule annotation
    Ordered Locus Names:EF_2999
    OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
    Taxonomic identifieri226185 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
    ProteomesiUP000001415: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454AllantoinasePRO_0000317674Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei149 – 1491N6-carboxylysineUniRule annotation

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi226185.EF2999.

    Structurei

    3D structure databases

    ProteinModelPortaliQ82ZQ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0044.
    KOiK01466.
    OMAiFREPGHT.
    OrthoDBiEOG6KHFW6.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    HAMAPiMF_01645. Hydantoinase.
    InterProiIPR017593. Allantoinase.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q82ZQ1-1 [UniParc]FASTAAdd to Basket

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    MQAELVIKNG LVILETGEVI TDVAVQGGKI VAIGQDLSGE RVIDATGLVV    50
    SPGMVDAHVH ITDPGGGYRD EWEGYVTGTA ACAKGGVTTF MEMPLNQIPA 100
    TVDKTSLEIK YKAGENKLKV DVGSFGGVVP TNLADGIQEL DEGGVSGYKC 150
    FLGTCGDRSI EGDFQNVDDY SLYEGMKQVA KTGKVLAIHA ENAPITDKLG 200
    AVAYQNGETT LAAYVATRPV FTEVEAIQKA ILFAKETGCR IHICHVACQE 250
    GVEEVLKAQA EGVDVTCETC THYLYFTTDE LDAIGPVVKC SPPIRDADQQ 300
    AALWNHVQTG GIAFVTSDHS PCTPDLKDTT NAFEAWGGIS GVQNNVDVLF 350
    DEAVQKRGLS LKQFADMIAA NPADRYHLAQ KGRISIGKDA DFVLIKPNAP 400
    YILKAEDLEY RNKISPYIGR EIGAQVIQTI LRGETIYAQE TGVTEAFNGV 450
    FIKN 454
    Length:454
    Mass (Da):48,713
    Last modified:June 1, 2003 - v1
    Checksum:iB5E4B3F04ED062F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO82684.1.
    RefSeqiNP_816614.1. NC_004668.1.

    Genome annotation databases

    EnsemblBacteriaiAAO82684; AAO82684; EF_2999.
    GeneIDi1201848.
    KEGGiefa:EF2999.
    PATRICi21856167. VBIEntFae7065_2796.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016830 Genomic DNA. Translation: AAO82684.1 .
    RefSeqi NP_816614.1. NC_004668.1.

    3D structure databases

    ProteinModelPortali Q82ZQ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226185.EF2999.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO82684 ; AAO82684 ; EF_2999 .
    GeneIDi 1201848.
    KEGGi efa:EF2999.
    PATRICi 21856167. VBIEntFae7065_2796.

    Phylogenomic databases

    eggNOGi COG0044.
    KOi K01466.
    OMAi FREPGHT.
    OrthoDBi EOG6KHFW6.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .
    BioCyci EFAE226185:GHI1-2930-MONOMER.

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    HAMAPi MF_01645. Hydantoinase.
    InterProi IPR017593. Allantoinase.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700802 / V583.

    Entry informationi

    Entry nameiALLB_ENTFA
    AccessioniPrimary (citable) accession number: Q82ZQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3