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Protein

Allantoinase

Gene

allB

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Zinc 1UniRule annotation
Metal bindingi60 – 601Zinc 1UniRule annotation
Metal bindingi149 – 1491Zinc 1; via carbamate groupUniRule annotation
Metal bindingi149 – 1491Zinc 2; via carbamate groupUniRule annotation
Metal bindingi189 – 1891Zinc 2UniRule annotation
Metal bindingi245 – 2451Zinc 2UniRule annotation
Metal bindingi318 – 3181Zinc 1UniRule annotation

GO - Molecular functioni

  1. allantoinase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: UniProtKB-HAMAP
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-2930-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Ordered Locus Names:EF_2999
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454AllantoinasePRO_0000317674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi226185.EF2999.

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0044.
KOiK01466.
OMAiHAEMIPP.
OrthoDBiEOG6KHFW6.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82ZQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAELVIKNG LVILETGEVI TDVAVQGGKI VAIGQDLSGE RVIDATGLVV
60 70 80 90 100
SPGMVDAHVH ITDPGGGYRD EWEGYVTGTA ACAKGGVTTF MEMPLNQIPA
110 120 130 140 150
TVDKTSLEIK YKAGENKLKV DVGSFGGVVP TNLADGIQEL DEGGVSGYKC
160 170 180 190 200
FLGTCGDRSI EGDFQNVDDY SLYEGMKQVA KTGKVLAIHA ENAPITDKLG
210 220 230 240 250
AVAYQNGETT LAAYVATRPV FTEVEAIQKA ILFAKETGCR IHICHVACQE
260 270 280 290 300
GVEEVLKAQA EGVDVTCETC THYLYFTTDE LDAIGPVVKC SPPIRDADQQ
310 320 330 340 350
AALWNHVQTG GIAFVTSDHS PCTPDLKDTT NAFEAWGGIS GVQNNVDVLF
360 370 380 390 400
DEAVQKRGLS LKQFADMIAA NPADRYHLAQ KGRISIGKDA DFVLIKPNAP
410 420 430 440 450
YILKAEDLEY RNKISPYIGR EIGAQVIQTI LRGETIYAQE TGVTEAFNGV

FIKN
Length:454
Mass (Da):48,713
Last modified:May 31, 2003 - v1
Checksum:iB5E4B3F04ED062F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82684.1.
RefSeqiNP_816614.1. NC_004668.1.

Genome annotation databases

EnsemblBacteriaiAAO82684; AAO82684; EF_2999.
GeneIDi1201848.
KEGGiefa:EF2999.
PATRICi21856167. VBIEntFae7065_2796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82684.1.
RefSeqiNP_816614.1. NC_004668.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF2999.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO82684; AAO82684; EF_2999.
GeneIDi1201848.
KEGGiefa:EF2999.
PATRICi21856167. VBIEntFae7065_2796.

Phylogenomic databases

eggNOGiCOG0044.
KOiK01466.
OMAiHAEMIPP.
OrthoDBiEOG6KHFW6.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.
BioCyciEFAE226185:GHI1-2930-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583.

Entry informationi

Entry nameiALLB_ENTFA
AccessioniPrimary (citable) accession number: Q82ZQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 4, 2008
Last sequence update: May 31, 2003
Last modified: March 31, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.