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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:EF_3135
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001706731 – 357Mannonate dehydrataseAdd BLAST357

Interactioni

Protein-protein interaction databases

STRINGi226185.EF3135.

Structurei

Secondary structure

1357
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni10 – 12Combined sources3
Helixi17 – 20Combined sources4
Beta strandi28 – 31Combined sources4
Beta strandi34 – 36Combined sources3
Helixi44 – 56Combined sources13
Beta strandi60 – 64Combined sources5
Helixi71 – 75Combined sources5
Helixi80 – 96Combined sources17
Beta strandi101 – 104Combined sources4
Beta strandi115 – 120Combined sources6
Beta strandi126 – 131Combined sources6
Helixi132 – 136Combined sources5
Helixi140 – 146Combined sources7
Helixi161 – 173Combined sources13
Helixi179 – 200Combined sources22
Beta strandi203 – 206Combined sources4
Beta strandi210 – 213Combined sources4
Helixi225 – 234Combined sources10
Helixi248 – 251Combined sources4
Helixi257 – 264Combined sources8
Helixi265 – 267Combined sources3
Beta strandi271 – 273Combined sources3
Beta strandi276 – 278Combined sources3
Beta strandi280 – 286Combined sources7
Helixi291 – 293Combined sources3
Beta strandi294 – 296Combined sources3
Helixi298 – 308Combined sources11
Beta strandi312 – 316Combined sources5
Beta strandi331 – 333Combined sources3
Helixi334 – 340Combined sources7
Helixi342 – 351Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TZ9X-ray2.90A/B1-357[»]
ProteinModelPortaliQ82ZC9.
SMRiQ82ZC9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ82ZC9.

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
KOiK01686.
OMAiEDNPPMD.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82ZC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWGFRWYGA AGDAIPLKHI RQIPGITGVV GTLLNKLPGD VWTVAEIQAL
60 70 80 90 100
KQSVEQEGLA LLGIESVAIH DAIKAGTDQR DHYIDNYRQT LRNLGKCGIS
110 120 130 140 150
LVCYSFKPIF GWAKTDLAYE NEDGSLSLLF DQAVVENMQP EDMYQLIHSQ
160 170 180 190 200
SKGFRLPGWE EERLQQFQEL KAMYAGVTEE DLVENLRYFL ERVIPVCEEE
210 220 230 240 250
NIKMGIHPDD PPWEIFGLPR ITKNLADLKR ILSLVDSPAN GITFCTGSLG
260 270 280 290 300
ADPTNDLPTM IREIGHRINF VHFRNVKYLG EHRFEETAHP SVAGSLDMAE
310 320 330 340 350
LMQALVDVGY EGVIRPDHGR AIWDEKAMPG YGLYDRAMGL TYIQGLYEAT

KAKQNRK
Length:357
Mass (Da):40,282
Last modified:June 1, 2003 - v1
Checksum:i4CA7E9E55D33A061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82813.1.
RefSeqiNP_816743.1. NC_004668.1.
WP_002388613.1. NZ_KE136524.1.

Genome annotation databases

EnsemblBacteriaiAAO82813; AAO82813; EF_3135.
GeneIDi1201978.
KEGGiefa:EF3135.
PATRICi21856425. VBIEntFae7065_2925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO82813.1.
RefSeqiNP_816743.1. NC_004668.1.
WP_002388613.1. NZ_KE136524.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TZ9X-ray2.90A/B1-357[»]
ProteinModelPortaliQ82ZC9.
SMRiQ82ZC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF3135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO82813; AAO82813; EF_3135.
GeneIDi1201978.
KEGGiefa:EF3135.
PATRICi21856425. VBIEntFae7065_2925.

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
KOiK01686.
OMAiEDNPPMD.

Enzyme and pathway databases

UniPathwayiUPA00246.

Miscellaneous databases

EvolutionaryTraceiQ82ZC9.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUXUA_ENTFA
AccessioniPrimary (citable) accession number: Q82ZC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.