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Q82Y17

- PANC_NITEU

UniProt

Q82Y17 - PANC_NITEU

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Protein
Pantothenate synthetase
Gene
panC, NE0073
Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton donor By similarity
Binding sitei57 – 571Beta-alanine By similarity
Binding sitei57 – 571Pantoate By similarity
Binding sitei149 – 1491Pantoate By similarity
Binding sitei172 – 1721ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338ATP By similarity
Nucleotide bindingi143 – 1464ATP By similarity
Nucleotide bindingi180 – 1834ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-83-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:NE0073
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Pantothenate synthetaseUniRule annotation
PRO_0000128249Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi228410.NE0073.

Structurei

3D structure databases

ProteinModelPortaliQ82Y17.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiHAGHMEL.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ82Y17.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82Y17-1 [UniParc]FASTAAdd to Basket

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MEIITDIAPL RARLRHEASV AFVPTMGNLH AGHLSLVRIA QKHASCSVVS    50
IFVNRLQFAP HEDFDRYPRT WSDDCRLLEE QGADIVFMPD EKTLYPVPQE 100
FQLLLPPVAD TLEGACRPGF FRGVTTVVLK LFNIVQPHIA VFGEKDYQQL 150
QVVHRMVDQL NLPVEIIAGE TVRDEDGLAL SSRNNYLDAT QRQEAGELAH 200
HLKQIRDSIA SGERDFPLLE QLAAEKLSKR GWVVDYVAVR QQHTLLPVAA 250
SDSSLVILGA AWLNQTRLID NFLLTLP 277
Length:277
Mass (Da):31,131
Last modified:June 1, 2003 - v1
Checksum:i8DA15A1056C92096
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD83984.1.
RefSeqiNP_840174.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD83984; CAD83984; NE0073.
GeneIDi1083596.
KEGGineu:NE0073.
PATRICi22710927. VBINitEur56163_0080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD83984.1 .
RefSeqi NP_840174.1. NC_004757.1.

3D structure databases

ProteinModelPortali Q82Y17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228410.NE0073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD83984 ; CAD83984 ; NE0073 .
GeneIDi 1083596.
KEGGi neu:NE0073.
PATRICi 22710927. VBINitEur56163_0080.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi HAGHMEL.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q82Y17.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci NEUR228410:GJNO-83-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiPANC_NITEU
AccessioniPrimary (citable) accession number: Q82Y17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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