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Q82Y17

- PANC_NITEU

UniProt

Q82Y17 - PANC_NITEU

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Protein

Pantothenate synthetase

Gene

panC

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton donorUniRule annotation
Binding sitei57 – 571Beta-alanineUniRule annotation
Binding sitei57 – 571PantoateUniRule annotation
Binding sitei149 – 1491PantoateUniRule annotation
Binding sitei172 – 1721ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338ATPUniRule annotation
Nucleotide bindingi143 – 1464ATPUniRule annotation
Nucleotide bindingi180 – 1834ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-83-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:NE0073
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Pantothenate synthetasePRO_0000128249Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi228410.NE0073.

Structurei

3D structure databases

ProteinModelPortaliQ82Y17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiHAGHMEL.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ82Y17.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82Y17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIITDIAPL RARLRHEASV AFVPTMGNLH AGHLSLVRIA QKHASCSVVS
60 70 80 90 100
IFVNRLQFAP HEDFDRYPRT WSDDCRLLEE QGADIVFMPD EKTLYPVPQE
110 120 130 140 150
FQLLLPPVAD TLEGACRPGF FRGVTTVVLK LFNIVQPHIA VFGEKDYQQL
160 170 180 190 200
QVVHRMVDQL NLPVEIIAGE TVRDEDGLAL SSRNNYLDAT QRQEAGELAH
210 220 230 240 250
HLKQIRDSIA SGERDFPLLE QLAAEKLSKR GWVVDYVAVR QQHTLLPVAA
260 270
SDSSLVILGA AWLNQTRLID NFLLTLP
Length:277
Mass (Da):31,131
Last modified:June 1, 2003 - v1
Checksum:i8DA15A1056C92096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD83984.1.
RefSeqiNP_840174.1. NC_004757.1.
WP_011110725.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD83984; CAD83984; NE0073.
GeneIDi1083596.
KEGGineu:NE0073.
PATRICi22710927. VBINitEur56163_0080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD83984.1 .
RefSeqi NP_840174.1. NC_004757.1.
WP_011110725.1. NC_004757.1.

3D structure databases

ProteinModelPortali Q82Y17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228410.NE0073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD83984 ; CAD83984 ; NE0073 .
GeneIDi 1083596.
KEGGi neu:NE0073.
PATRICi 22710927. VBINitEur56163_0080.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi HAGHMEL.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q82Y17.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci NEUR228410:GJNO-83-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiPANC_NITEU
AccessioniPrimary (citable) accession number: Q82Y17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3