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Q82XV5

- NDK_NITEU

UniProt

Q82XV5 - NDK_NITEU

Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

    Catalytic activityi

    ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111ATPUniRule annotation
    Binding sitei59 – 591ATPUniRule annotation
    Binding sitei87 – 871ATPUniRule annotation
    Binding sitei93 – 931ATPUniRule annotation
    Binding sitei104 – 1041ATPUniRule annotation
    Binding sitei114 – 1141ATPUniRule annotation
    Active sitei117 – 1171Pros-phosphohistidine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. nucleoside diphosphate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. CTP biosynthetic process Source: UniProtKB-HAMAP
    2. GTP biosynthetic process Source: UniProtKB-HAMAP
    3. UTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNEUR228410:GJNO-152-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
    Short name:
    NDKUniRule annotation
    Short name:
    NDP kinaseUniRule annotation
    Alternative name(s):
    Nucleoside-2-P kinaseUniRule annotation
    Gene namesi
    Name:ndkUniRule annotation
    Ordered Locus Names:NE0144
    OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
    Taxonomic identifieri228410 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
    ProteomesiUP000001416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 141141Nucleoside diphosphate kinasePRO_0000137014Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi228410.NE0144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ82XV5.
    SMRiQ82XV5. Positions 2-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NDK family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0105.
    HOGENOMiHOG000224565.
    KOiK00940.
    OMAiAAWRELM.
    OrthoDBiEOG67DPRV.
    PhylomeDBiQ82XV5.

    Family and domain databases

    Gene3Di3.30.70.141. 1 hit.
    HAMAPiMF_00451. NDP_kinase.
    InterProiIPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view]
    PfamiPF00334. NDK. 1 hit.
    [Graphical view]
    PRINTSiPR01243. NUCDPKINASE.
    SMARTiSM00562. NDK. 1 hit.
    [Graphical view]
    SUPFAMiSSF54919. SSF54919. 1 hit.
    PROSITEiPS00469. NDP_KINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q82XV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVERTLSII KPDAVAKNVI GQIYARFEAA GLKVVAARMA HLSRVEAENF    50
    YAIHRERPFF KDLVEFMISG PVMIQVLEGE NAIARNRELM GATDPRKAEK 100
    GTIRADFAES IDANAVHGSD APETAVVEIA CFFPSLEIHS R 141
    Length:141
    Mass (Da):15,541
    Last modified:June 1, 2003 - v1
    Checksum:i882ED7A944629FDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954747 Genomic DNA. Translation: CAD84055.1.
    RefSeqiNP_840240.1. NC_004757.1.
    WP_011110791.1. NC_004757.1.

    Genome annotation databases

    EnsemblBacteriaiCAD84055; CAD84055; NE0144.
    GeneIDi1081051.
    KEGGineu:NE0144.
    PATRICi22711093. VBINitEur56163_0163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954747 Genomic DNA. Translation: CAD84055.1 .
    RefSeqi NP_840240.1. NC_004757.1.
    WP_011110791.1. NC_004757.1.

    3D structure databases

    ProteinModelPortali Q82XV5.
    SMRi Q82XV5. Positions 2-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228410.NE0144.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD84055 ; CAD84055 ; NE0144 .
    GeneIDi 1081051.
    KEGGi neu:NE0144.
    PATRICi 22711093. VBINitEur56163_0163.

    Phylogenomic databases

    eggNOGi COG0105.
    HOGENOMi HOG000224565.
    KOi K00940.
    OMAi AAWRELM.
    OrthoDBi EOG67DPRV.
    PhylomeDBi Q82XV5.

    Enzyme and pathway databases

    BioCyci NEUR228410:GJNO-152-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.141. 1 hit.
    HAMAPi MF_00451. NDP_kinase.
    InterProi IPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view ]
    Pfami PF00334. NDK. 1 hit.
    [Graphical view ]
    PRINTSi PR01243. NUCDPKINASE.
    SMARTi SM00562. NDK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54919. SSF54919. 1 hit.
    PROSITEi PS00469. NDP_KINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
      Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
      J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19718 / NBRC 14298.

    Entry informationi

    Entry nameiNDK_NITEU
    AccessioniPrimary (citable) accession number: Q82XV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3