Reviewed, UniProtKB/Swiss-Prot Q82XE0 (HIS82_NITEU)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	NE0336

Organism

Nitrosomonas europaea [Complete proteome] [HAMAP]

Taxonomic identifier

915 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosomonas

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000153405
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q82XE0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 16CA3514175513E1	FASTA	373	41,225
	10 20 30 40 50 60 MMNLSELAPD YIRAIQPYQP GKPISELVRD LGLNKDEVVK LASNENPLGT SPLAKEAMIQ 70 80 90 100 110 120 ALNESARYPD GSGFELKAAL SERLGMPADQ IVLGNGSNDV LELATRIFLH PDSTAIYSQY 130 140 150 160 170 180 AFAIYPLLAQ AVGARGIAVP ARNYGHDLEA MLAAVTPETR IIFIANPNNP TGTLCDARDL 190 200 210 220 230 240 LRFMERVPQD VLVILDEAYD EYLPEANKAN SIAWLKNFQN LVITRTFSKA YGLASVRVGF 250 260 270 280 290 300 ALAHADIANL MNRIRQPFNV NSIGLAAAQA ALKDVEFVKL AYMTNRTGMQ QMTHGLDQLG 310 320 330 340 350 360 IEYIPSFGNF VCCHIDGHPA NTLKIYRNLL QQGVIVRPLG NYDMLNHLRV TIGIEEENKR 370 FLQALEQALK ELD

References

[1]

"Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea." Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J. J. Bacteriol. 185:2759-2773(2003) [PubMed: 12700255] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19718 / IFO 14298.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL954747 Genomic DNA. Translation: CAD84247.1.
RefSeq	NP_840423.1.
3D structure databases
SMR	Q82XE0. Positions 15-369.
ModBase	Search...
Genome annotation databases
GeneID	1081266.
GenomeReviews	Gene locus NE0336 in contig AL954747_GR.
KEGG	neu:NE0336.
NMPDR	fig|228410.1.peg.322.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646350.
OMA	RITLGNG.
Enzyme and pathway databases
BioCyc	NEUR228410:NE0336-MONOMER.
BRENDA	2.6.1.9. 444.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_NITEU

Accession

Primary (citable) accession number: Q82XE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)