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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581UniRule annotation
Active sitei592 – 5921UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-609-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:NE0589
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 933933Phosphoenolpyruvate carboxylasePRO_0000166605Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228410.NE0589.

Structurei

3D structure databases

ProteinModelPortaliQ82WS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.
PhylomeDBiQ82WS3.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82WS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNTRANII PEKNTPNEKD YPLREDIRLL GRMLGDTIRE LEGETMFNLV
60 70 80 90 100
ETIRQTSVRF RRDQDEAAEH ELDTILNHLS HKETIAVVRA FSYFSLLSNI
110 120 130 140 150
AEDLHHNRRR RAHLRAGSPP QDGSVTLALQ RVVKKGIDAE QLQNFFASAL
160 170 180 190 200
ISPVLTAHPT EVQRRSILDY QLKIQRLLKE RDRTQLTPNE MRHNEEDLRS
210 220 230 240 250
AIQTLWQTRV LRSVRLTVQD EIENGLIYYH YTFLRQIPYI YAKLEDILER
260 270 280 290 300
HMDKAAPRIA SFLRIGSWIG GDRDGNPFVT HQIMLHAAER HSALILDFYI
310 320 330 340 350
SEVERIGQTM SLSERLIKVS SDLEGLASTA PGLPASRIDE PYRRVFLGIH
360 370 380 390 400
ARLIATSRHL GSSIRGCCQE NNAEPYADSA EFVHDLDIVI RSLRQHRSDR
410 420 430 440 450
LAQGALRDLR RAADVFGFHL APLDMRQHSK IHEQVISELY EKNTRDDRNY
460 470 480 490 500
LEMSRSERVE WLLAELRHPR SLVTSFSDFS DVTQGELRIL KMAAEIQRRF
510 520 530 540 550
GHAALPNYII SMATGVVHIL EVALLLKEAG LLQFGDDPRS TVNIIPLFET
560 570 580 590 600
IDDLRGCASV MDELFSLPDY RKLLLSRDNL QEVMLGYSDS NKDGGFVTSN
610 620 630 640 650
WEIYKAEIEL TRVFDRHGVR LRLFHGRGGT VGRGGGPSYQ GILAQPPGSV
660 670 680 690 700
SGQIRLTEQG EVIASKYTDP EIGRRNLETL VAATIESTLL DRDAVHYHAP
710 720 730 740 750
HYHQIMEELS SSACAAYRDL VYKTPGFKQF FLESTPIREI AGLHIGSRPT
760 770 780 790 800
SRKPSDKIED LRAIPWVFSW SLNRTMIPGW YGFGTAVENF VQQAGNEQEA
810 820 830 840 850
LKQLQEMYRT WPFLQTLLSN MDMVLSKSDL GIASRYAELV TDPELRQSVF
860 870 880 890 900
TSIRTEWELC MKWLFAITGY SELLQDNPTL ARSIRIRTPY IDPLNHLQIE
910 920 930
LLRRYRSGDD DDTVRRAIHL TINGVATGLR NSG
Length:933
Mass (Da):106,618
Last modified:June 1, 2003 - v1
Checksum:i6EAEB45A0178C906
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84500.1.
RefSeqiNP_840673.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD84500; CAD84500; NE0589.
GeneIDi1081528.
KEGGineu:NE0589.
PATRICi22712107. VBINitEur56163_0658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84500.1.
RefSeqiNP_840673.1. NC_004757.1.

3D structure databases

ProteinModelPortaliQ82WS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228410.NE0589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD84500; CAD84500; NE0589.
GeneIDi1081528.
KEGGineu:NE0589.
PATRICi22712107. VBINitEur56163_0658.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.
PhylomeDBiQ82WS3.

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-609-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiCAPP_NITEU
AccessioniPrimary (citable) accession number: Q82WS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.