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Q82WQ4 (GCSPA_NITEU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:NE0609
OrganismNitrosomonas europaea (strain ATCC 19718 / NBRC 14298) [Complete proteome] [HAMAP]
Taxonomic identifier228410 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166968

Sequences

Sequence LengthMass (Da)Tools
Q82WQ4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: D790D6D788F9A469

FASTA45349,646
        10         20         30         40         50         60 
MPFIPHTEED VAEMLTSIGA RSIDELFDEI PAELKTGKLT QVPPGLSEME ISRLMYERAQ 

        70         80         90        100        110        120 
QDGFYLSFIG AGAYEHHIPA AVWQITTRGE FYSSYTPYQA EASQGTLQLL YEYQTMMASL 

       130        140        150        160        170        180 
AGMDVSNASL YDGASALAEA ALMAVRQHRT SRRILVPQTV HPVYRSVMRT IVRNQAIEVV 

       190        200        210        220        230        240 
EVPYDPATGQ VAIDKLDQFA QEEFAALIIP QPNFFGVLEQ VDALTDWAHD KQSLAVAVVN 

       250        260        270        280        290        300 
PTSLAMLKPP GEWGRRGADI AVGEGQPLGI PLSSGGPYFG FMTCKQELVR QMPGRIIGRT 

       310        320        330        340        350        360 
TDLEGKEGFA LTLQAREQHI RRSKATSNIC TNQGLMVTAA TIYMSLLGPE GLYRVAAHSH 

       370        380        390        400        410        420 
ANTVALVEQL EKLPGVKKAF HSPFFHEAAL QLSVPADKVL NRLKAQGVLG GVLLENHYPD 

       430        440        450 
LKNTLLVCAT ETKTAEDLDK YTEVLRQALA ASA 

« Hide

References

[1]"Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19718 / NBRC 14298.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL954747 Genomic DNA. Translation: CAD84520.1.
RefSeqNP_840693.1. NC_004757.1.

3D structure databases

ProteinModelPortalQ82WQ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228410.NE0609.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD84520; CAD84520; NE0609.
GeneID1081548.
KEGGneu:NE0609.
PATRIC22712153. VBINitEur56163_0681.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycNEUR228410:GJNO-629-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_NITEU
AccessionPrimary (citable) accession number: Q82WQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families