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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciNEUR228410:G1G1I-665-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:NE0609
OrganismiNitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669681 – 453Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST453

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi228410.NE0609

Structurei

3D structure databases

ProteinModelPortaliQ82WQ4
SMRiQ82WQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108EYQ Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN
PhylomeDBiQ82WQ4

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q82WQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIPHTEED VAEMLTSIGA RSIDELFDEI PAELKTGKLT QVPPGLSEME
60 70 80 90 100
ISRLMYERAQ QDGFYLSFIG AGAYEHHIPA AVWQITTRGE FYSSYTPYQA
110 120 130 140 150
EASQGTLQLL YEYQTMMASL AGMDVSNASL YDGASALAEA ALMAVRQHRT
160 170 180 190 200
SRRILVPQTV HPVYRSVMRT IVRNQAIEVV EVPYDPATGQ VAIDKLDQFA
210 220 230 240 250
QEEFAALIIP QPNFFGVLEQ VDALTDWAHD KQSLAVAVVN PTSLAMLKPP
260 270 280 290 300
GEWGRRGADI AVGEGQPLGI PLSSGGPYFG FMTCKQELVR QMPGRIIGRT
310 320 330 340 350
TDLEGKEGFA LTLQAREQHI RRSKATSNIC TNQGLMVTAA TIYMSLLGPE
360 370 380 390 400
GLYRVAAHSH ANTVALVEQL EKLPGVKKAF HSPFFHEAAL QLSVPADKVL
410 420 430 440 450
NRLKAQGVLG GVLLENHYPD LKNTLLVCAT ETKTAEDLDK YTEVLRQALA

ASA
Length:453
Mass (Da):49,646
Last modified:June 1, 2003 - v1
Checksum:iD790D6D788F9A469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA Translation: CAD84520.1
RefSeqiWP_011111235.1, NC_004757.1

Genome annotation databases

EnsemblBacteriaiCAD84520; CAD84520; NE0609
KEGGineu:NE0609

Similar proteinsi

Entry informationi

Entry nameiGCSPA_NITEU
AccessioniPrimary (citable) accession number: Q82WQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health