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Q82WQ3

- GCSPB_NITEU

UniProt

Q82WQ3 - GCSPB_NITEU

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, NE0610
Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-630-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:NE0610
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi228410.NE0610.

Structurei

3D structure databases

ProteinModelPortaliQ82WQ3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiVRALTYM.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ82WQ3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82WQ3-1 [UniParc]FASTAAdd to Basket

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MLIFEHSRKN RRNYSQAPAT RPAKNNIPDH LKRKSTPLLP EVSEMDTVRH    50
YTRLSQKNFS IDTEFYPLGS CTMKYNPRAC NSLAMLPQFL SRHPLAPEDT 100
GQGFLACMYE LQEILKDITG MAAVSLTSMA GAQGELIGIT MIRAYHEAHG 150
DTGRTEIIIP DAAHGTNPAT AVMCGYKVIE IPTNRDGDVD MDALKAAVGP 200
KTAGLMLTNP STLGVFEKKV AEMSRIVHAA GGLLYYDGAN LNAVLGKVKP 250
GDMGFDVIHM NLHKTFSTPH GGGGPGAAPV GVAERLLPYL PVPIVAHEQG 300
VYRWLTEEDR PQTIGRLSAH MGNAGVLLRA YIYVRLLGAE GMHRISEYAT 350
LNANYLMAEL RKLGFEIAYP NRRASHEFIV TMKEIKDRTG VTAMNLAKRL 400
LDKGFHAPTT YFPLLVPECL LIEPAETESK ETLDRFVAAM KEILDEIATQ 450
PDMVKAAPHD MPLRKIDDVK AARELDLVWD PAG 483
Length:483
Mass (Da):53,184
Last modified:June 1, 2003 - v1
Checksum:iDF677FBA2763DEC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD84521.1.
RefSeqiNP_840694.1. NC_004757.1.
WP_011111236.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD84521; CAD84521; NE0610.
GeneIDi1081549.
KEGGineu:NE0610.
PATRICi22712155. VBINitEur56163_0682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD84521.1 .
RefSeqi NP_840694.1. NC_004757.1.
WP_011111236.1. NC_004757.1.

3D structure databases

ProteinModelPortali Q82WQ3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 228410.NE0610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD84521 ; CAD84521 ; NE0610 .
GeneIDi 1081549.
KEGGi neu:NE0610.
PATRICi 22712155. VBINitEur56163_0682.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi VRALTYM.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q82WQ3.

Enzyme and pathway databases

BioCyci NEUR228410:GJNO-630-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiGCSPB_NITEU
AccessioniPrimary (citable) accession number: Q82WQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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